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J Cancer 2012; 3:158-165. doi:10.7150/jca.4211 This volume Cite

Mini-Review/Case Report

Combination of the Deacetylase Inhibitor Panobinostat and the Multi-Kinase Inhibitor Sorafenib for the Treatment of Metastatic Hepatocellular Carcinoma - Review of the Underlying Molecular Mechanisms and First Case Report

Susanne Gahr1,2, Till Wissniowski1,3, Steffen Zopf1, Deike Strobel1, Anette Pustowka4, Matthias Ocker1,5 ✉

1. Department of Medicine 1, University Hospital Erlangen, Erlangen, Germany
2. Klinikum Nuremberg Nord, Department of Pneumology, Nuremberg, Germany
3. Division of Gastroenterology, University Hospital Marburg, Marburg, Germany
4. Novartis Pharma GmbH, Nuremberg, Germany
5. Institute for Surgical Research, Philipps University Marburg, Marburg, Germany

✉ Corresponding author: Prof. Dr. med. Matthias Ocker, Institute for Surgical Research, Philipps University Marburg, Baldingerstrasse, 35033 Marburg, Germany. ockeruni-marburg.de; Phone: +49-6421-5868930; Fax: +49-6421-5868926

Citation:
Gahr S, Wissniowski T, Zopf S, Strobel D, Pustowka A, Ocker M. Combination of the Deacetylase Inhibitor Panobinostat and the Multi-Kinase Inhibitor Sorafenib for the Treatment of Metastatic Hepatocellular Carcinoma - Review of the Underlying Molecular Mechanisms and First Case Report. J Cancer 2012; 3:158-165. doi:10.7150/jca.4211. https://www.jcancer.org/v03p0158.htm
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Abstract

Advanced hepatocellular carcinoma still represents an unmet medical need that has only a limited overall survival despite the introduction of the multi-kinase inhibitor sorafenib. Recently, inhibitors of histone and other protein deacetylases have been established as novel therapeutic approaches to cancer diseases. We here review the molecular rationale for combining these two novel targeted therapies and report a patient with metastasized hepatocellular carcinoma who showed a partial remission of primary and metastatic lesions for five months after a combination therapy with sorafenib and the orally available pan-deacetylase inhibitor panobinostat.

Keywords: hepatocellular carcinoma, sorafenib, panobinostat, deacetylase inhibitor

Citation styles

APA
Gahr, S., Wissniowski, T., Zopf, S., Strobel, D., Pustowka, A., Ocker, M. (2012). Combination of the Deacetylase Inhibitor Panobinostat and the Multi-Kinase Inhibitor Sorafenib for the Treatment of Metastatic Hepatocellular Carcinoma - Review of the Underlying Molecular Mechanisms and First Case Report. Journal of Cancer, 3, 158-165. https://doi.org/10.7150/jca.4211.

ACS
Gahr, S.; Wissniowski, T.; Zopf, S.; Strobel, D.; Pustowka, A.; Ocker, M. Combination of the Deacetylase Inhibitor Panobinostat and the Multi-Kinase Inhibitor Sorafenib for the Treatment of Metastatic Hepatocellular Carcinoma - Review of the Underlying Molecular Mechanisms and First Case Report. J. Cancer 2012, 3, 158-165. DOI: 10.7150/jca.4211.

NLM
Gahr S, Wissniowski T, Zopf S, Strobel D, Pustowka A, Ocker M. Combination of the Deacetylase Inhibitor Panobinostat and the Multi-Kinase Inhibitor Sorafenib for the Treatment of Metastatic Hepatocellular Carcinoma - Review of the Underlying Molecular Mechanisms and First Case Report. J Cancer 2012; 3:158-165. doi:10.7150/jca.4211. https://www.jcancer.org/v03p0158.htm

CSE
Gahr S, Wissniowski T, Zopf S, Strobel D, Pustowka A, Ocker M. 2012. Combination of the Deacetylase Inhibitor Panobinostat and the Multi-Kinase Inhibitor Sorafenib for the Treatment of Metastatic Hepatocellular Carcinoma - Review of the Underlying Molecular Mechanisms and First Case Report. J Cancer. 3:158-165.

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