J Cancer 2012; 3:117-121. doi:10.7150/jca.3977
Infectious Diseases Are Analogous With Cancer. Hypothesis And Implications
Department of Pathology, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Benharroch D, Osyntsov L. Infectious Diseases Are Analogous With Cancer. Hypothesis And Implications. J Cancer 2012; 3:117-121. doi:10.7150/jca.3977. Available from http://www.jcancer.org/v03p0117.htm
We propose to disclose first degree analogous features between cancer and infectious diseases and to find out whether these similarities are superficial and negligible, due to the use of the same bodily pathways by the two categories of disease or if they represent significantly parallel characteristics. We have found several primary analogous features, predominantly regarding pathways of spread, but to some extent also concerning the interaction with the immune system. Some of the implications to our hypothesis are probably available in the recent literature, at the experimental or clinical levels. For example endostatin, an angiogenic inhibitor has been used to prevent promotion of metastasis in cancer and to reduce granulomas formation in schistosomiasis. An ECFR antagonist employed to restrain bronchial vessels proliferation in pseudomonas infection, has also been used for the treatment of lung cancer.
Keywords: cancer, infectious disease, analogy, spread, immunity.