ISSN: 1837-9664Journal of Cancer
Global reach, higher impact
J Cancer 2022; 13(15):3674-3686. doi:10.7150/jca.78090 This issue Cite
Review
Understanding the Dual Roles of CircHIPK3 in Tumorigenesis and Tumor Progression
1. NHC Key Laboratory of Carcinogenesis, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, China.
2. Xiangya Stomatological Hospital, Central South University, Changsha, Hunan 410078, China.
3. Cancer Research Institute, Central South University, Changsha, Hunan 410078, China.
4. The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Central South University, Changsha, Hunan 410078, China.
#These authors contributed equally to this work.
Abstract
CircHIPK3 is a type of endogenous circular RNA, which contains a covalently closed circular structure and cannot encode protein or polypeptide. CircHIPK3 is unusually expressed in varieties of tumors and plays dual roles of tumor promotion or tumor inhibition in tumorigenesis and development of tumors by serving as the sponge for miRNA in multiple tumors. Here, we reviewed the differential expression, the dual functions, the regulation mechanism, and the network in a variety of tumors as well as the potential value for the diagnosis and treatment of tumors, which are of great significance for our comprehensive understanding of the roles and mechanisms of circHIPK3 in tumors.
Keywords: circHIPK3, dual roles, differential expression, regulation mechanism, tumorigenesis
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