J Cancer
2021; 12(4):1190-1199.
doi:10.7150/jca.52720 This issueCite
Review
Research progress in the role and mechanism of Cadherin-11 in different diseases
Xinyi Chen, Hongjiao Xiang, Shiyu Yu, Yifei Lu, Tao Wu✉
Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
✉ Corresponding author: Tao Wu, PhD, Assistant Professor, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China. E-mail: tw827edu.cn or wutao001827com; Telephone: +86-21-51322748; Fax: +86-21-51322748.More
Citation:
Chen X, Xiang H, Yu S, Lu Y, Wu T. Research progress in the role and mechanism of Cadherin-11 in different diseases. J Cancer 2021; 12(4):1190-1199. doi:10.7150/jca.52720. https://www.jcancer.org/v12p1190.htm
Cadherin is an important cell-cell adhesion molecule, which mediates intercellular adhesion through calcium dependent affinity interaction. Cadherin-11 (CDH11, OB-cadherin) is a member of cadherin family, and its gene is situated on chromosome 16q22.1. Increasing lines of researches have proved that CDH11 plays important roles in the occurrence and development of a lot of diseases, such as tumors, arthritis and so on. CDH11 often leads to promoter methylation inactivation, which can induce cancer cell apoptosis, suppress cell motility and invasion, and can inhibit cancer through Wnt/β-catenin, AKT/Rho A and NF-κB signaling pathways. This review focused on the current knowledge of CDH11, including its function and mechanism in different diseases. In this article, we aimed to have a more comprehensive and in-depth understanding of CDH11 and to provide new ideas for the treatment of some diseases.
Chen, X., Xiang, H., Yu, S., Lu, Y., Wu, T. (2021). Research progress in the role and mechanism of Cadherin-11 in different diseases. Journal of Cancer, 12(4), 1190-1199. https://doi.org/10.7150/jca.52720.
ACS
Chen, X.; Xiang, H.; Yu, S.; Lu, Y.; Wu, T. Research progress in the role and mechanism of Cadherin-11 in different diseases. J. Cancer 2021, 12 (4), 1190-1199. DOI: 10.7150/jca.52720.
NLM
Chen X, Xiang H, Yu S, Lu Y, Wu T. Research progress in the role and mechanism of Cadherin-11 in different diseases. J Cancer 2021; 12(4):1190-1199. doi:10.7150/jca.52720. https://www.jcancer.org/v12p1190.htm
CSE
Chen X, Xiang H, Yu S, Lu Y, Wu T. 2021. Research progress in the role and mechanism of Cadherin-11 in different diseases. J Cancer. 12(4):1190-1199.
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