J Cancer
2021; 12(2):508-517.
doi:10.7150/jca.50575 This issueCite
Research Paper
Preoperative Denosumab may increase the Risk of Local Recurrence of Giant-cell Tumor of Bone Treated with Curettage: A Systematic Review and Meta-analysis
Yongzhao Zhao*, Zhenyu Cai*, Xiaodong Tang✉, Zhiye Du, Yi Yang, Wei Guo✉
Musculoskeletal Tumor Center, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing 100044, China. *These authors contributed equally to this study.
✉ Corresponding authors: Xiaodong Tang, MD. Musculoskeletal Tumor Center, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing 100044, China. E-mail: tang15877com; OR Wei Guo, MD. Musculoskeletal Tumor Center, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing 100044, China. E-mail: bonetumorcom.More
Citation:
Zhao Y, Cai Z, Tang X, Du Z, Yang Y, Guo W. Preoperative Denosumab may increase the Risk of Local Recurrence of Giant-cell Tumor of Bone Treated with Curettage: A Systematic Review and Meta-analysis. J Cancer 2021; 12(2):508-517. doi:10.7150/jca.50575. https://www.jcancer.org/v12p0508.htm
Objective: This systematic review and meta-analysis aimed to determine the effect of preoperative denosumab on the local recurrence of giant-cell tumor of bone (GCTB) treated with curettage.
Methods: PubMed, Embase, Cochrane Library, and Web of Science were comprehensively searched. The following data were analyzed using meta-analysis: local recurrence rate of patients receiving denosumab followed by curettage (denosumab group), local recurrence rate of patients receiving curettage only (control group), and a comparison of the local recurrence rates of the two groups.
Results: Nine studies that contained 672 patients with GCTB were included in this review. Patients in the denosumab group (preoperative denosumab followed by curettage) had a higher risk of local recurrence compared with those in the control group (curettage only) (odds ratio = 3.04, 95% confidence interval = 1.48-6.22, P < 0.01). The association between preoperative denosumab and local recurrence remained significant in most of the subgroup analyses, except for those with sample sizes < 59 (P = 0.09), sacral GCTB (P = 0.42), and usage of postoperative denosumab (P = 0.38).
Conclusions: Preoperative denosumab may increase the risk of local recurrence of GCTB treated with curettage and should be used with caution in the management of GCTB.
Keywords: Denosumab, Giant-cell Tumor of Bone, Local recurrence, Meta-analysis
Citation styles
APA
Zhao, Y., Cai, Z., Tang, X., Du, Z., Yang, Y., Guo, W. (2021). Preoperative Denosumab may increase the Risk of Local Recurrence of Giant-cell Tumor of Bone Treated with Curettage: A Systematic Review and Meta-analysis. Journal of Cancer, 12(2), 508-517. https://doi.org/10.7150/jca.50575.
ACS
Zhao, Y.; Cai, Z.; Tang, X.; Du, Z.; Yang, Y.; Guo, W. Preoperative Denosumab may increase the Risk of Local Recurrence of Giant-cell Tumor of Bone Treated with Curettage: A Systematic Review and Meta-analysis. J. Cancer 2021, 12 (2), 508-517. DOI: 10.7150/jca.50575.
NLM
Zhao Y, Cai Z, Tang X, Du Z, Yang Y, Guo W. Preoperative Denosumab may increase the Risk of Local Recurrence of Giant-cell Tumor of Bone Treated with Curettage: A Systematic Review and Meta-analysis. J Cancer 2021; 12(2):508-517. doi:10.7150/jca.50575. https://www.jcancer.org/v12p0508.htm
CSE
Zhao Y, Cai Z, Tang X, Du Z, Yang Y, Guo W. 2021. Preoperative Denosumab may increase the Risk of Local Recurrence of Giant-cell Tumor of Bone Treated with Curettage: A Systematic Review and Meta-analysis. J Cancer. 12(2):508-517.
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