J Cancer 2020; 11(24):7264-7275. doi:10.7150/jca.44727

Review

Fibroblast growth factor receptor signaling as therapeutic targets in female reproductive system cancers

Dong-Li Zhu1,2,3, Xiao-Mei Tuo2, Yu Rong2, Kun Zhang1✉, Yan Guo1,2✉

1. Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Trauma Surgery, Honghui Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China.
2. Biomedical Informatics & Genomics Center, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China, 710054.
3. Research institute of Xi'an Jiaotong University, Hangzhou, Zhejiang, P. R. China, 311215.

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Citation:
Zhu DL, Tuo XM, Rong Y, Zhang K, Guo Y. Fibroblast growth factor receptor signaling as therapeutic targets in female reproductive system cancers. J Cancer 2020; 11(24):7264-7275. doi:10.7150/jca.44727. Available from https://www.jcancer.org/v11p7264.htm

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Abstract

Ovarian cancer, cervical cancer and endometrial cancer are three relatively common malignant cancers of the female reproductive system. Despite improvements in female genital tract cancer detection and development of new therapeutic approaches, there are still poor prognoses and some do not respond to therapeutic patterns, displaying low survival and high frequency of recurrence. In an era of personalized medicine, novel therapeutic approaches with greater efficacy for these cancers represent an unmet need. One of the actionable signaling pathways is the fibroblast growth factor receptor (FGFR) signaling pathway. Several mutations and alterations in FGF/FGFR family members have been reported in human cancers. FGF/FGFR signaling pathway has become a new target for cancer therapy. This review will summarize the role of FGFR pathway and the genetic alterations of the FGF/FGFR related to female reproductive system cancer. We will describe the available inhibitors of FGFR pathway for potential treatment of female reproductive system cancer. Furthermore, we will discuss FGFR-targeted therapies under clinical development for treatment of female reproductive system cancer.

Keywords: Fibroblast growth factor, Fibroblast growth factor receptor, Genetic variations, Therapeutic targets, Female reproductive system cancer