J Cancer 2020; 11(23):6760-6767. doi:10.7150/jca.45819

Research Paper

High expression of CD34 and α6-integrin contributes to the cancer-initiating cell behaviour in ultraviolet-induced mouse skin squamous cell carcinoma

Hengning Ke1,2,3,4, YvYing Yang1,3, Yuan Lin4, Li Liu3, Jianmin Sun4, Ramin Massoumi2✉

1. Hubei AIDS Clinical Training Center, Department of Infectious Disease, Zhongnan Hospital, Wuhan University, Wuhan, P.R. China.
2. Department of Laboratory Medicine, Translational Cancer Research, Lund University, Medicon Village, Lund, Sweden.
3. Cancer Research Institute, General Hospital, Ningxia Medical University, Yinchuan, P.R. China.
4. School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, P.R. China.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Citation:
Ke H, Yang Y, Lin Y, Liu L, Sun J, Massoumi R. High expression of CD34 and α6-integrin contributes to the cancer-initiating cell behaviour in ultraviolet-induced mouse skin squamous cell carcinoma. J Cancer 2020; 11(23):6760-6767. doi:10.7150/jca.45819. Available from http://www.jcancer.org/v11p6760.htm

File import instruction

Abstract

Squamous cell carcinoma caused by ultraviolet light exposure represents over 40% of all malignant diseases. It is one of the most commonly found human tumours. Tumour mass within squamous cell carcinoma consists of various cell types, including cancer-initiating cells that are responsible for tumour progression, metastasis and chemoresistance and implicated in clinical relapse. In the present study, we aimed to characterise whether the cell population with high CD34 and α6-integrin expression behave as cancer-initiating cells within ultraviolet-induced squamous cell carcinoma in mouse skin. CD34highα6-integrinhigh compared to CD34lowα6-integrinhigh cells isolated from ultraviolet-induced squamous cell carcinoma could propagate effectively by displaying greater tumour initiating and self-renewal abilities. Our study suggests that CD34highα6-integrinhigh cells act as initiators upon ultraviolet-induced skin squamous cell carcinoma.

Keywords: UV-B, CD34, α6-integrin, squamous cell carcinoma