J Cancer 2020; 11(7):1761-1767. doi:10.7150/jca.38598 This issue Cite

Review

Role of de novo cholesterol synthesis enzymes in cancer

Jie Yang1,2, Lihua Wang1,2✉, Renbing Jia1,2✉

1. Department of Ophthalmology, Ninth People's Hospital of Shanghai, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
2. Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China.

Citation:
Yang J, Wang L, Jia R. Role of de novo cholesterol synthesis enzymes in cancer. J Cancer 2020; 11(7):1761-1767. doi:10.7150/jca.38598. https://www.jcancer.org/v11p1761.htm
Other styles

File import instruction

Abstract

Despite extensive research in the cancer field, cancer remains one of the most prevalent diseases. There is an urgent need to identify specific targets that are safe and effective for the treatment of cancer. In recent years, cancer metabolism has come into the spotlight in cancer research. Lipid metabolism, especially cholesterol metabolism, plays a critical role in membrane synthesis as well as lipid signaling in cancer. This review focuses on the contribution of the de novo cholesterol synthesis pathway to tumorigenesis, cancer progression and metastasis. In conclusion, cholesterol metabolism could be an effective target for novel anticancer treatment.

Keywords: metabolic reprogramming, de novo cholesterol synthesis, cancer progress


Citation styles

APA
Yang, J., Wang, L., Jia, R. (2020). Role of de novo cholesterol synthesis enzymes in cancer. Journal of Cancer, 11(7), 1761-1767. https://doi.org/10.7150/jca.38598.

ACS
Yang, J.; Wang, L.; Jia, R. Role of de novo cholesterol synthesis enzymes in cancer. J. Cancer 2020, 11 (7), 1761-1767. DOI: 10.7150/jca.38598.

NLM
Yang J, Wang L, Jia R. Role of de novo cholesterol synthesis enzymes in cancer. J Cancer 2020; 11(7):1761-1767. doi:10.7150/jca.38598. https://www.jcancer.org/v11p1761.htm

CSE
Yang J, Wang L, Jia R. 2020. Role of de novo cholesterol synthesis enzymes in cancer. J Cancer. 11(7):1761-1767.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image