Difference in the short-term outcomes of laparoscopic gastrectomy for gastric carcinoma between the east and west: a retrospective study from the IMIGASTRIC trial

Lin, Jian-Xian; Lin, Jun-Peng; Desiderio, Jacopo; Xie, Jian-Wei; Gemini, Alessandro; Wang, Jia-bin; Lu, Jun; Chen, Qi-Yue; Cao, Long-long; Lin, Mi; Tu, Ruhong; Zheng, Chao-Hui; Li, Ping; Parisi, Amilcare; Huang, Chang-Ming

doi:10.7150/jca.31192

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J Cancer 2019; 10(17):4106-4113. doi:10.7150/jca.31192 This issue Cite

Research Paper

Difference in the short-term outcomes of laparoscopic gastrectomy for gastric carcinoma between the east and west: a retrospective study from the IMIGASTRIC trial

Jian-Xian Lin^1,2#, Jun-Peng Lin^1,2#, Jacopo Desiderio^3#, Jian-Wei Xie^1,2, Alessandro Gemini³, Jia-bin Wang^1,2, Jun Lu^1,2, Qi-Yue Chen^1,2, Long-long Cao^1,2, Mi Lin^1,2, Ruhong Tu^1,2, Chao-Hui Zheng^1,2, Ping Li^1,2✉, Amilcare Parisi^3✉, Chang-Ming Huang^1,2✉

1. Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China
2. Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian Province, China
3. Department of Digestive Surgery, St. Mary's Hospital, University of Perugia, Terni, Italy
^# Lin JX, Lin JP, and Desiderio J contributed equally to this work and should be considered co-first authors.

Citation:

Lin JX, Lin JP, Desiderio J, Xie JW, Gemini A, Wang Jb, Lu J, Chen QY, Cao Ll, Lin M, Tu R, Zheng CH, Li P, Parisi A, Huang CM. Difference in the short-term outcomes of laparoscopic gastrectomy for gastric carcinoma between the east and west: a retrospective study from the IMIGASTRIC trial. J Cancer 2019; 10(17):4106-4113. doi:10.7150/jca.31192. https://www.jcancer.org/v10p4106.htm

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Abstract

Purpose: To compare the clinicopathologic data and short-term surgical outcomes of laparoscopic gastrectomy (LG) for gastric cancer (GC) between the east and west.

Methods: Patient demographics, surgical procedures, pathological information, and postoperative recovery were compared among gastric cancer patients who underwent LG in the clinical trial of IMIGASTRIC (NCT02325453) between 2009 and 2016.

Results: More younger males, higher BMI, lower ASA score and less neoadjvant chemotherapy were evident in east patient cohort. Eastern patients had a higher proportion of proximal, differentiated and advanced gastric cancers. More total gastrectomies, larger extent of lymph node (LN) dissection, and higher number of retrieved LNs were found in the eastern patients. However, more Roux-en-Y anastomosis procedures during distal gastrectomy and intra-corporeal anastomosis were performed in the western patients. The west patients showed faster postoperative recovery than the eastern patients. The mortality rates of the western patients were comparable to those of the eastern patients. However, fewer III-IV complications were evident in the eastern centers. Multivariate analyses revealed that an elderly age, higher ASA score, and more blood loss were the significant independent risk factors of postoperative complications for eastern patients. However, for the western patients, the independent risk factors were neoadjuvant therapy, more retrieval LNs, and pT3-4 stage.

Conclusions: The selections and short-term surgical outcomes of LG for GC were widely different between East and West. To obtain more objective and accurate results, these differences should be considered in future international prospective studies.

Keywords: stomach neoplasm, laparoscopic gastrectomy, surgical outcomes, postoperative complications, Clavien-Dindo classification

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APA

Lin, J.X., Lin, J.P., Desiderio, J., Xie, J.W., Gemini, A., Wang, J.b., Lu, J., Chen, Q.Y., Cao, L.l., Lin, M., Tu, R., Zheng, C.H., Li, P., Parisi, A., Huang, C.M. (2019). Difference in the short-term outcomes of laparoscopic gastrectomy for gastric carcinoma between the east and west: a retrospective study from the IMIGASTRIC trial. Journal of Cancer, 10(17), 4106-4113. https://doi.org/10.7150/jca.31192.

ACS

Lin, J.X.; Lin, J.P.; Desiderio, J.; Xie, J.W.; Gemini, A.; Wang, J.b.; Lu, J.; Chen, Q.Y.; Cao, L.l.; Lin, M.; Tu, R.; Zheng, C.H.; Li, P.; Parisi, A.; Huang, C.M. Difference in the short-term outcomes of laparoscopic gastrectomy for gastric carcinoma between the east and west: a retrospective study from the IMIGASTRIC trial. J. Cancer 2019, 10 (17), 4106-4113. DOI: 10.7150/jca.31192.

NLM

CSE

Lin JX, Lin JP, Desiderio J, Xie JW, Gemini A, Wang Jb, Lu J, Chen QY, Cao Ll, Lin M, Tu R, Zheng CH, Li P, Parisi A, Huang CM. 2019. Difference in the short-term outcomes of laparoscopic gastrectomy for gastric carcinoma between the east and west: a retrospective study from the IMIGASTRIC trial. J Cancer. 10(17):4106-4113.

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