J Cancer 2019; 10(12):2694-2705. doi:10.7150/jca.31877

Review

The Role of the Slit/Robo Signaling Pathway

Mingfu Tong1,2, Tie Jun2✉, Yongzhan Nie2, Jianyu Hao1✉, Daiming Fan2✉

1. Department of Gastroenterology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
2. State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.

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Citation:
Tong M, Jun T, Nie Y, Hao J, Fan D. The Role of the Slit/Robo Signaling Pathway. J Cancer 2019; 10(12):2694-2705. doi:10.7150/jca.31877. Available from http://www.jcancer.org/v10p2694.htm

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Abstract

The Slit family is a family of secreted proteins that play important roles in various physiologic and pathologic activities via interacting with Robo receptors. Slit/Robo signaling was first identified in the nervous system, where it functions in neuronal axon guidance; nevertheless, an increasing number of studies have shown that Slit/Robo signaling even regulates other activities, such as angiogenesis, inflammatory cell chemotaxis, tumor cell migration and metastasis. Although the precise role of the ligand-receptor in organisms has been obscure and the conclusions drawn are sometimes paradoxical, tremendous advances in understanding the Slit/Robo signaling pathway have been made. As such, our review summarizes the characteristics of the Slit/Robo signaling pathway and its role in various cell types.

Keywords: Slit, Robo, neuro, angiogenesis, chemotaxis, cancer, motility