Pro-oncogene Pokemon Promotes Prostate Cancer Progression by Inducing STRN4 Expression

Jiang, Fuquan; Zheng, Qingfan; Chang, Liping; Li, Xu; Wang, Xinsheng; Gu, Xinquan

doi:10.7150/jca.29471

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J Cancer 2019; 10(8):1833-1845. doi:10.7150/jca.29471 This issue Cite

Research Paper

Pro-oncogene Pokemon Promotes Prostate Cancer Progression by Inducing STRN4 Expression

Fuquan Jiang¹, Qingfan Zheng¹, Liping Chang², Xu Li¹, Xinsheng Wang^3✉, Xinquan Gu^1✉

1. Department of Urology, China-Japan Union Hospital of Jilin University, Jilin, China
2. The First Affiliated Hospital, Changchun University of Chinese Traditional Medicine, Jilin, China
3. Department of Urology, Tianjin First Center Hospital, Tianjin, China

Citation:

Jiang F, Zheng Q, Chang L, Li X, Wang X, Gu X. Pro-oncogene Pokemon Promotes Prostate Cancer Progression by Inducing STRN4 Expression. J Cancer 2019; 10(8):1833-1845. doi:10.7150/jca.29471. https://www.jcancer.org/v10p1833.htm

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Abstract

Pokemon, also known as leukemia/lymphoma-related factor (LRF) is a pro-oncogenic protein highly expressed in several cancers. There have been few in vitro and animal studies about its malignant biological behavior and function, however, its role especially in prostate cancer has not been completely elucidated. Therefore, in this study, we identified that Pokemon is overexpressed in human prostate cancer tissue samples, and its suppression inhibits proliferation of prostate cancer cells, along with promotion of apoptosis. Furthermore, to explore the mechanism by which Pokemon promotes tumor progression, we observed that it binds to the promoter of STRN4 (striatin 4), a downstream target, and subsequently regulates its expression. In conclusion, our study indicated that Pokemon through stimulation of STRN4 expression promotes prostate tumor progression via a Pokemon /STRN4 axis.

Keywords: Pokemon, STRN4, prostate cancer, proliferation, apoptosis

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APA

Jiang, F., Zheng, Q., Chang, L., Li, X., Wang, X., Gu, X. (2019). Pro-oncogene Pokemon Promotes Prostate Cancer Progression by Inducing STRN4 Expression. Journal of Cancer, 10(8), 1833-1845. https://doi.org/10.7150/jca.29471.

ACS

Jiang, F.; Zheng, Q.; Chang, L.; Li, X.; Wang, X.; Gu, X. Pro-oncogene Pokemon Promotes Prostate Cancer Progression by Inducing STRN4 Expression. J. Cancer 2019, 10 (8), 1833-1845. DOI: 10.7150/jca.29471.

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CSE

Jiang F, Zheng Q, Chang L, Li X, Wang X, Gu X. 2019. Pro-oncogene Pokemon Promotes Prostate Cancer Progression by Inducing STRN4 Expression. J Cancer. 10(8):1833-1845.

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