LncRNA GACAT1 Promotes Gastric Cancer Cell Growth, Invasion And Migration By Regulating MiR-149-mediated Of ZBTB2 And SP1

Shi, Xiaoqing; Wang, Xiaoqin; Hua, Yimin

doi:10.7150/jca.27546

International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

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J Cancer 2018; 9(20):3715-3722. doi:10.7150/jca.27546 This issue Cite

Research Paper

LncRNA GACAT1 Promotes Gastric Cancer Cell Growth, Invasion And Migration By Regulating MiR-149-mediated Of ZBTB2 And SP1

Xiaoqing Shi^✉, Xiaoqin Wang, Yimin Hua^✉

West China Second University Hospital, Sichuan University, Chengdu, China

Citation:

Shi X, Wang X, Hua Y. LncRNA GACAT1 Promotes Gastric Cancer Cell Growth, Invasion And Migration By Regulating MiR-149-mediated Of ZBTB2 And SP1. J Cancer 2018; 9(20):3715-3722. doi:10.7150/jca.27546. https://www.jcancer.org/v09p3715.htm

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Abstract

Long non-coding RNAs (lncRNAs) were involved in the progression of gastric cancer (GC). In our study, we have determined that GACAT1 expression was upregulated in GC. Overexpression of GACAT1 promoted GC cell proliferation, invasion and migration. We also determined that miR-149 directly interacts with the target site on GACAT1. Furthermore, we investigated that miR-149 downregulated ZBTB2 and SP1 expressions which were induced by GACAT1, miR-149 inhibited GC cell growth and invasion mediated by GACAT1. In conclusion, we found that miR-149 downregulated ZBTB2 and SP1 expressions, and inhibited GC cell progression mediated by GACAT1. Therefore, we indicated that GACAT1 and miR-149 may be potential therapeutic targets for GC.

Keywords: GACAT1, miR-149, ZBTB2, SP1, Gastric cancer, Invasion

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APA

Shi, X., Wang, X., Hua, Y. (2018). LncRNA GACAT1 Promotes Gastric Cancer Cell Growth, Invasion And Migration By Regulating MiR-149-mediated Of ZBTB2 And SP1. Journal of Cancer, 9(20), 3715-3722. https://doi.org/10.7150/jca.27546.

ACS

Shi, X.; Wang, X.; Hua, Y. LncRNA GACAT1 Promotes Gastric Cancer Cell Growth, Invasion And Migration By Regulating MiR-149-mediated Of ZBTB2 And SP1. J. Cancer 2018, 9 (20), 3715-3722. DOI: 10.7150/jca.27546.

NLM

CSE

Shi X, Wang X, Hua Y. 2018. LncRNA GACAT1 Promotes Gastric Cancer Cell Growth, Invasion And Migration By Regulating MiR-149-mediated Of ZBTB2 And SP1. J Cancer. 9(20):3715-3722.

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