J Cancer 2018; 9(7):1301-1307. doi:10.7150/jca.23984
A Survival Model in Locally Advanced and Metastatic Pancreatic Ductal Adenocarcinoma
1. Department of Oncology, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai Cancer Institute, Shanghai, China, 200127
2. Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine (originally named “Shanghai First People's Hospital”), Shanghai, China, 201620
*these authors contributed equally to this work.
Wang Y, Xiao X, Wang T, Li L, Zhu Y, Xu H, Chu Y, Jiao F, Cui J, Wang L. A Survival Model in Locally Advanced and Metastatic Pancreatic Ductal Adenocarcinoma. J Cancer 2018; 9(7):1301-1307. doi:10.7150/jca.23984. Available from http://www.jcancer.org/v09p1301.htm
The prognostic role of serum LDH, CA19-9, CRP and ALB in PDAC patients are controversial. In contrast to single factor, there is much less information about the prognostic value of the combination of the four factors in locally advanced and metastatic PDAC patients. It's essential to set up a survival model with the combination of tumor metabolism, tumor biomarker, systemic inflammation and nutritional status to eliminate the prognostic inaccuracy in single biomarker. 94 advanced PDAC patients who received palliative chemotherapy from 2009 to 2017 were recruited for this study. The predictive value of pretreatment serum LDH, CA19-9, CRP and ALB levels for OS were evaluated, and the same as combination of the four factors. It was confirmed that serum LDH, CA19-9, CRP and ALB levels were independent prognostic factors for OS by multivariate analyses. The results of Kaplan-Meier analyses revealed that serum LDH, CA19-9, CRP, ALB levels as well as the combination of the four factors were correlated with OS. It's concluded that the combination of the pretreatment serum LDH, CA19-9, CRP and ALB levels is a prognostic factor for advanced PDAC patients.
Keywords: Pancreatic cancer, Lactate Dehydrogenase, CA-19-9 Antigen, C-reactive protein, Albumin, Prognosis