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J Cancer 2017; 8(19):4141-4154. doi:10.7150/jca.22076 This issue Cite

Review

Post-transcriptional Regulation of Genes Related to Biological Behaviors of Gastric Cancer by Long Noncoding RNAs and MicroRNAs

Wenjing Liu^1,2, Rui Ma², Yuan Yuan^1,3✉

1. Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department, Shenyang, 110001, Liaoning Province, P R China;
2. Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, NO. 44 Xiaoheyan Road, Dadong District, Shenyang 110042, Liaoning Province, P R China;
3. National Clinical Research Center for Digestive Diseases, Xi'an, 110001 China.

✉ Corresponding author: Dr. Yuan Yuan, Tumor Etiology and Screening Department of Cancer Institute and General Surgery, North Nanjing Street 155#, Heping District, Shenyang 110001, China Telephone: +86-024-83282153; fax: +86-024-83282383, Email: yuanyuanedu.cn More

Abstract

Noncoding RNAs play critical roles in regulating protein-coding genes and comprise two major classes: long noncoding RNAs (lncRNAs) and microRNAs (miRNAs). LncRNAs regulate gene expression at transcriptional, post-transcriptional, and epigenetic levels via multiple action modes. LncRNAs can also function as endogenous competitive RNAs for miRNAs and indirectly regulate gene expression post-transcriptionally. By binding to the 3'-untranslated regions (3'-UTR) of target genes, miRNAs post-transcriptionally regulate gene expression. Herein, we conducted a review of post-transcriptional regulation by lncRNAs and miRNAs of genes associated with biological behaviors of gastric cancer.

Keywords: ncRNAs, lncRNAs, miRNAs, gastric cancer, post-transcriptional regulation.

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