Osteopontin is Critical for Hyperactive mTOR-Induced Tumorigenesis in Oral Squamous Cell Carcinoma

Gan, Ning; Zou, Sihai; Hang, Wenming; Yang, Deqin; Zhang, Xuemei; Yin, Yibing

doi:10.7150/jca.18031

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J Cancer 2017; 8(8):1362-1370. doi:10.7150/jca.18031 This issue Cite

Research Paper

Osteopontin is Critical for Hyperactive mTOR-Induced Tumorigenesis in Oral Squamous Cell Carcinoma

Ning Gan^{1, 2, 3, 4}, Sihai Zou^{1, 2, 3}, Wenming Hang^{1, 2, 3}, Deqin Yang^{1, 2, 3}, Xuemei Zhang⁴, Yibing Yin^4✉

1. Stomatological Hospital of Chongqing Medical University, Chongqing 401147, China;
2. Chongqing key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 401147, China;
3. Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 401147, China;
4. Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine (Ministry of Education), Chongqing Medical University, Chongqing 400016, China.

Citation:

Gan N, Zou S, Hang W, Yang D, Zhang X, Yin Y. Osteopontin is Critical for Hyperactive mTOR-Induced Tumorigenesis in Oral Squamous Cell Carcinoma. J Cancer 2017; 8(8):1362-1370. doi:10.7150/jca.18031. https://www.jcancer.org/v08p1362.htm

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Abstract

Mechanistic target of rapamycin (mTOR) plays a critical role in the development of oral squamous cell carcinoma (OSCC), but the underlying mechanisms remain poorly understood. Here we have demonstrated that the expression of osteopontin (OPN) was dramatically up-regulated in OSCC tissues and cell lines. Moreover, reduction of OPN suppressed cell proliferation, colony formation, and in vivo tumorigenic ability of OSCC cell lines Tca8113. In addition, there was a strong positive correlation between mTORC1 activity and OPN expression in OSCC tissues and cell lines. Furthermore, mTOR complex 1 (mTORC1) enhanced OPN expression through up-regulation of ERRα. Therefore, OPN is a downstream target of mTORC1 and is crucial for OSCC development. mTORC1, ERRα, and OPN may be potential targets for treatment of OSCC with aberrant mTORC1 signaling.

Keywords: mTOR, ERRα, OPN, tumorigenesis, OSCC.

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APA

Gan, N., Zou, S., Hang, W., Yang, D., Zhang, X., Yin, Y. (2017). Osteopontin is Critical for Hyperactive mTOR-Induced Tumorigenesis in Oral Squamous Cell Carcinoma. Journal of Cancer, 8(8), 1362-1370. https://doi.org/10.7150/jca.18031.

ACS

Gan, N.; Zou, S.; Hang, W.; Yang, D.; Zhang, X.; Yin, Y. Osteopontin is Critical for Hyperactive mTOR-Induced Tumorigenesis in Oral Squamous Cell Carcinoma. J. Cancer 2017, 8 (8), 1362-1370. DOI: 10.7150/jca.18031.

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CSE

Gan N, Zou S, Hang W, Yang D, Zhang X, Yin Y. 2017. Osteopontin is Critical for Hyperactive mTOR-Induced Tumorigenesis in Oral Squamous Cell Carcinoma. J Cancer. 8(8):1362-1370.

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