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J Cancer 2016; 7(1):95-106. doi:10.7150/jca.13340 This issue Cite

Review

Comparison of Prognostic MicroRNA Biomarkers in Blood and Tissues for Gastric Cancer

Wenying Yan^{1, 2, 3}, Laijun Qian⁴, Jiajia Chen⁵, Weichang Chen^1✉, Bairong Shen^{3 ✉}

1. Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China;
2. Taicang Center for Translational Bioinformatics, Taicang 215400, China;
3. Center for Systems Biology, Soochow University, Suzhou 215006, China;
4. Daibu Center Hospital, Liyang, 213330, China;
5. School of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology, Suzhou 215011, China.

✉ Corresponding authors: Professor Bairong Shen, email: bairong.shenedu.cn or to Professor Weichang Chen, email: weichangchencom

Abstract

Gastric cancer (GC) still keeps up high mortality worldwide with poor prognosis. Efficient and non-invasive prognostic biomarkers are urgently needed. MicroRNAs are non-coding RNAs playing roles in post-transcriptional gene regulation, which contribute to various biological processes such as development, differentiation and carcinogenesis. MicroRNA expression profiles have been associated with the prognosis and outcome in GC. MicroRNA prognostic biomarkers have been identified from blood or tissues samples, but with different prognostic features. Understanding the various roles of microRNAs in different sample sources of GC will provide deep insights into GC progression. In this review, we highlight the distinct prognostic roles of microRNAs biomarkers in blood and tissue according to their relationships with prognostic parameters, survival rates and target pathways. This will be useful for non-invasive biomarker development and selection in prognosis of GC.

Keywords: blood, gastric cancer, microRNA, prognostic biomarker, tissues

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