Volume 3; 2012

Research Paper
Preoperative Thyroid Ultrasound Is Indicated in Patients Undergoing Parathyroidectomy for Primary Hyperparathyroidism
Cletus A. Arciero, Zita S. Shiue, Jeremy D. Gates, George E. Peoples, Alan P. B. Dackiw, Ralph P. Tufano, Steven K. Libutti, Martha A. Zeiger, Alexander Stojadinovic
J. Cancer 2012; 3: 1-6. doi:10.7150/jca.3.1
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Progression-free Survival Decreases with Each Subsequent Therapy in Patients Presenting for Phase I Clinical Trials
Christopher H. Bailey, Gayle Jameson, Chao Sima, Sharon Fleck, Erica White, Daniel D. Von Hoff, Glen J. Weiss
J. Cancer 2012; 3: 7-13. doi:10.7150/jca.3.7
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Case Report
Endometrioid Adenocarcinoma with High-Grade Transformation with Serous and Choriocarcinomatous Differentiation - A Case Report
Senn Wakahashi, Tamotsu Sudo, Eriko Nakagawa, Sayaka Ueno, Miho Muraji, Seiji Kanayama, Hiroe Itami, Fumi Kawakami, Takashi Yamada, Satoshi Yamaguchi, Kiyoshi Fujiwara, Hironobu Nishikawa, Ryuichiro Nishimura, Chiho Ohbayashi
J. Cancer 2012; 3: 14-18. doi:10.7150/jca.3.14
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Promising Candidate Urinary MicroRNA Biomarkers for the Early Detection of Hepatocellular Carcinoma among High-Risk Hepatitis C Virus Egyptian Patients
Moemen AK Abdalla, Yousef Haj-Ahmad
J. Cancer 2012; 3: 19-31. doi:10.7150/jca.3.19
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Properties of Lewis Lung Carcinoma Cells Surviving Curcumin Toxicity
Dejun Yan, Michael E. Geusz, Roudabeh J. Jamasbi
J. Cancer 2012; 3: 32-41. doi:10.7150/jca.3659
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Diabetes and Risk of Renal Cell Carcinoma
Samy L Habib, Thomas J Prihoda, Maria Luna, Sherry A Werner
J. Cancer 2012; 3: 42-48. doi:10.7150/jca.3718
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
A Meta-Analysis of the Short- And Long-Term Results of Randomized Controlled Trials That Compared Laparoscopy-Assisted and Open Colectomy for Colon Cancer
Hiroshi Ohtani, Yutaka Tamamori, Yuichi Arimoto, Yukio Nishiguchi, Kiyoshi Maeda, Kosei Hirakawa
J. Cancer 2012; 3: 49-57. doi:10.7150/jca.3621
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Case Report
Molecular Characterization of a Patient's Small Cell Carcinoma of the Ovary of the Hypercalcemic Type
Bret Stephens, Stephen P. Anthony, Haiyong Han, Jeffery Kiefer, Galen Hostetter, Michael Barrett, Daniel D. Von Hoff
J. Cancer 2012; 3: 58-66. doi:10.7150/jca.3872
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Telomerase-Independent Paths to Immortality in Predictable Cancer Subtypes
Stephen T Durant
J. Cancer 2012; 3: 67-82. doi:10.7150/jca.3965
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
A 40-50kDa Glycoprotein Associated with Mucus is Identified as α-1-Acid Glycoprotein in Carcinoma of the Stomach
Nthato Chirwa, Dhirendra Govender, Bongani Ndimba, Zoe Lotz, Marilyn Tyler, Eugenio Panieri, Delawir Kahn, Anwar S Mall
J. Cancer 2012; 3: 83-92. doi:10.7150/jca.3737
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Short Research Communication
A Quick, Cost-Free Method of Purification of DNA Fragments from Agarose Gel
Yuan Sun, Kannappan Sriramajayam, Dianzhong Luo, D. Joshua Liao
J. Cancer 2012; 3: 93-95. doi:10.7150/jca.4163
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Case Report
Prostatic Metastasis of Pulmonary Large Cell Neuroendocrine Carcinoma
Kumi Shimizu, Taichiro Goto, Arafumi Maeshima, Yoshitaka Oyamada, Ryoichi Kato
J. Cancer 2012; 3: 96-99. doi:10.7150/jca.3770
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Case Report
Xanthogranulomatous Inflammation of the Female Genital Tract: Report of Three Cases
Xiang-sheng Zhang, Hong-yan Dong, Lei-lei Zhang, Mohamed Mokhtar Desouki, Chengquan Zhao
J. Cancer 2012; 3: 100-106. doi:10.7150/jca.3929
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Additively Enhanced Antiproliferative Effect of Interferon Combined with Proanthocyanidin on Bladder Cancer Cells
Andrew I. Fishman, Blake Johnson, Bobby Alexander, John Won, Muhammad Choudhury, Sensuke Konno
J. Cancer 2012; 3: 107-112. doi:10.7150/jca.4107
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Short Report
All Cancers Age-Adjusted Mortality Rate Surpasses Diseases of the Heart
Stephen W. Wyatt, Hollie R. Sands, William Ryan Maynard, Kraig E. Humbaugh
J. Cancer 2012; 3: 113-116. doi:10.7150/jca.4111
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Infectious Diseases Are Analogous With Cancer. Hypothesis And Implications
Daniel Benharroch, Lidia Osyntsov
J. Cancer 2012; 3: 117-121. doi:10.7150/jca.3977
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Prostate Cancers Detected During 5α-Reductase Inhibitor Use Are Smaller, De-Differentiated, But Confined when Compared To Controls
Fred Lee, Robert A. Badalament, Chen Hu, Ingrid Bousho, Alex Tsodikov
J. Cancer 2012; 3: 122-128. doi:10.7150/jca.4123
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Does the Loss of ARID1A (BAF-250a) Expression in Endometrial Clear Cell Carcinomas Have Any Clinicopathologic Significance? A Pilot Assessment
Oluwole Fadare, Idris L. Renshaw, Sharon X. Liang
J. Cancer 2012; 3: 129-136. doi:10.7150/jca.4140
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
HER2 as a Prognostic Marker in Gastric Cancer - A Systematic Analysis of Data from the Literature
Jan Trøst Jørgensen, Maria Hersom
J. Cancer 2012; 3: 137-144. doi:10.7150/jca.4090
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
A Phase II Study of Concurrent Docetaxel, Epirubicin and Cyclophosphamide as a Neoadjuvant Chemotherapy Regimen in Patients with Locally Advanced Breast Cancer
Xin Yao, Janet Hosenpud, Christopher R. Chitambar, John Charlson, Yee Chung Cheng
J. Cancer 2012; 3: 145-151. doi:10.7150/jca.3980
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Targeting the mTOR pathway in Chromophobe Kidney Cancer
Brian Shuch, Srinivas Vourganti, Julia C. Friend, Lee M. Zehngebot, W. Marston Linehan, Ramaprasad Srinivasan
J. Cancer 2012; 3: 152-157. doi:10.7150/jca.4378
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Mini-review/Case Report
Combination of the Deacetylase Inhibitor Panobinostat and the Multi-Kinase Inhibitor Sorafenib for the Treatment of Metastatic Hepatocellular Carcinoma - Review of the Underlying Molecular Mechanisms and First Case Report
Susanne Gahr, Till Wissniowski, Steffen Zopf, Deike Strobel, Anette Pustowka, Matthias Ocker
J. Cancer 2012; 3: 158-165. doi:10.7150/jca.4211
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Stemness of the CT-2A Immunocompetent Mouse Brain Tumor Model: Characterization In Vitro
Emanuela Binello, Zulekha A. Qadeer, Harini P. Kothari, Luni Emdad, Isabelle M. Germano
J. Cancer 2012; 3: 166-174. doi:10.7150/jca.4149
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
ASPN and GJB2 Are Implicated in the Mechanisms of Invasion of Ductal Breast Carcinomas
Bàrbara Castellana, Daniel Escuin, Gloria Peiró, Bárbara Garcia-Valdecasas, Tania Vázquez, Cristina Pons, Maitane Pérez-Olabarria, Agustí Barnadas, Enrique Lerma
J. Cancer 2012; 3: 175-183. doi:10.7150/jca.4120
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Liver Directed Therapy for Renal Cell Carcinoma
Russell C. Langan, R. Taylor Ripley, Jeremy L. Davis, Peter A. Prieto, Nicole Datrice, Seth M. Steinberg, Gennady Bratslavsky, Udo Rudloff, Udai S. Kammula, Alexander Stojadinovic, Itzhak Avital
J. Cancer 2012; 3: 184-190. doi:10.7150/jca.4456
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
The Effect of Abdominal Radical Trachelectomy on Ovarian Reserve: Serial Changes in Serum Anti-Müllerian Hormone Levels
Miho Muraji, Tamotsu Sudo, Shinichi Iwasaki, Sayaka Ueno, Senn Wakahashi, Satoshi Yamaguchi, Kiyoshi Fujiwara, Ryuichiro Nishimura
J. Cancer 2012; 3: 191-195. doi:10.7150/jca.4316
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Establishment of Human Ultra-Low Passage Colorectal Cancer Cell Lines Using Spheroids from Fresh Surgical Specimens Suitable for In Vitro and In Vivo Studies
Satyajit Ray, Russell C. Langan, John E. Mullinax, Tomotake Koizumi, Hong-Wu Xin, Gordon W. Wiegand, Andrew J. Anderson, Alexander Stojadinovic, Snorri Thorgeirsson, Udo Rudloff, Itzhak Avital
J. Cancer 2012; 3: 196-206. doi:10.7150/jca.4484
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Current Practice Patterns Regarding the Conduct of Thyroidectomy and Parathyroidectomy amongst Surgeons - A Survey Study
LR Henry, LB Helou, NP Solomon, A Chang, SK Libutti, A Stojadinovic
J. Cancer 2012; 3: 207-216. doi:10.7150/jca.4452
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Patient Satisfaction with Physician Discussions of Treatment Impact on Fertility, Menopause and Sexual Health among Pre-menopausal Women with Cancer
Maura Scanlon, Anne Blaes, Melissa Geller, Navneet S Majhail, Bruce Lindgren, Tufia Haddad
J. Cancer 2012; 3: 217-225. doi:10.7150/jca.4408
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Case Report
A Case Report: Lobular Carcinoma In Situ in a Male Patient with Subsequent Invasive Ductal Carcinoma Identified on Screening Breast MRI
Linda Kao, Yekaterina Bulkin, Susan Fineberg, Leslie Montgomery, Tova Koenigsberg
J. Cancer 2012; 3: 226-230. doi:10.7150/jca.4091
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
A Pilot Study Assessing the Potential Role of non-CD133 Colorectal Cancer Stem Cells as Biomarkers
Russell C. Langan, John E. Mullinax, Satyajit Ray, Manish T. Raiji, Nicholas Schaub, Hong-Wu Xin, Tomotake Koizumi, Seth M. Steinberg, Andrew Anderson, Gordon Wiegand, Donna Butcher, Miriam Anver, Anton J. Bilchik, Alexander Stojadinovic, Udo Rudloff, Itzhak Avital
J. Cancer 2012; 3: 231-240. doi:10.7150/jca.4542
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Short Research Communication
FDG PET/CT Response Evaluation in Malignant Pleural Mesothelioma Patients Treated with Talc Pleurodesis and Chemotherapy
Giovenzio Genestreti, Andrea Moretti, Sara Piciucchi, Noemi Giovannini, Riccardo Galassi, Emanuela Scarpi, Marco Angelo Burgio, Dino Amadori, Stefano Sanna, Venerino Poletti, Federica Matteucci, Giampaolo Gavelli
J. Cancer 2012; 3: 241-245. doi:10.7150/jca.2586
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Incidence of Malignancy after Living Kidney Transplantation: A Multicenter Study from Iran
Behzad Einollahi, Zohreh Rostami, Mohammad Hossein Nourbala, Mahboob Lessan-Pezeshki, Naser Simforoosh, Eghlim Nemati, Vahid Pourfarziani, Fatemeh Beiraghdar, Mohsen Nafar, Fatemeh Pour-Reza-Gholi, MitraMahdavi Mazdeh, Manochehr Amini, Pedram Ahmadpour, Khadijeh Makhdoomi, Ali Ghafari, Mohammad Reza Ardalan, Hamid Taebi Khosroshahi, Farshid Oliaei, Shahrzad Shahidi, Shahin Abbaszadeh, Mohammad Reza Fatahi, Fatemeh Hiedari, Atehieh Makhlogh, Jalal Azmandian, Hmid Reza Samimagham, Heshmatollah Shahbazian, Fatemeh Nazemian, Massih Naghibi, Masoud Khosravi, Ali Monfared, SeyedMajid Mosavi, Javad Ahmadi, Mojgan Jalalzadeh
J. Cancer 2012; 3: 246-256. doi:10.7150/jca.3042
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Cetuximab in Refractory Skin Cancer Treatment
Sini J Kalapurakal, James Malone, K. Thomas Robbins, Lucinda Buescher, John Godwin, Krishna Rao
J. Cancer 2012; 3: 257-261. doi:10.7150/jca.3491
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
A Mathematical Model of Human Papillomavirus (HPV) in the United States and its Impact on Cervical Cancer
Shernita L. Lee, Ana M. Tameru
J. Cancer 2012; 3: 262-268. doi:10.7150/jca.4161
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Identification of Potential Glycoprotein Biomarkers in Estrogen Receptor Positive (ER+) and Negative (ER-) Human Breast Cancer Tissues by LC-LTQ/FT-ICR Mass Spectrometry
Suzan M. Semaan, Xu Wang, Alan G. Marshall, Qing-Xiang Amy Sang
J. Cancer 2012; 3: 269-284. doi:10.7150/jca.4592
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Analysis of Pancreatic Cancer Microenvironment: Role of Macrophage Infiltrates and Growth Factors Expression
Katarzyna Gardian, Sława Janczewska, Waldemar L. Olszewski, Marek Durlik
J. Cancer 2012; 3: 285-291. doi:10.7150/jca.4537
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Trends of Incidence and Survival of Gastrointestinal Neuroendocrine Tumors in the United States: A Seer Analysis
Vassiliki L. Tsikitis, Betsy C. Wertheim, Marlon A. Guerrero
J. Cancer 2012; 3: 292-302. doi:10.7150/jca.4502
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Mini-Review/Case Report
Malignant Peripheral Nerve Sheath Tumors: Differentiation Patterns and Immunohistochemical Features - A Mini-Review and Our New Findings
Aitao Guo, Aijun Liu, Lixin Wei, Xin Song
J. Cancer 2012; 3: 303-309. doi:10.7150/jca.4179
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Effect of Tumour Necrosis Factor-Alpha on Estrogen Metabolic Pathways in Breast Cancer Cells
Marwa Kamel, Samia Shouman, Mahmoud El-Merzebany, Gokhan Kilic, Timothy Veenstra, Muhammad Saeed, Mohamed Wagih, Concepcion Diaz-Arrastia, Deepa Patel, Salama Salama
J. Cancer 2012; 3: 310-321. doi:10.7150/jca.4584
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Primary Refractory and Relapsed Classical Hodgkin Lymphoma - Significance of Differential CD15 Expression in Hodgkin-Reed-Sternberg Cells
Daniel Benharroch, Shai Pilosof, Jacob Gopas, Itai Levi
J. Cancer 2012; 3: 322-327. doi:10.7150/jca.4716
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Mini-Review
Infiltrating Lobular Carcinoma of the Breast Presenting as Gastrointestinal Obstruction: A Mini Review
Carcoforo P, Raiji MT, Langan RC, Lanzara S, Portinari M, Maestroni U, Palini GM, Zanzi MV, Bonazza S, Pedriali M, Feo CV, Stojadinovic A, Avital I
J. Cancer 2012; 3: 328-332. doi:10.7150/jca.4735
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Inhibition of Breast Tumor Cell Growth by Ectopic Expression of p16/INK4A Via Combined Effects of Cell Cycle Arrest, Senescence and Apoptotic Induction, and Angiogenesis Inhibition
Yi Lu, Xiongwen Zhang, Jun Zhang
J. Cancer 2012; 3: 333-344. doi:10.7150/jca.4046
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
The Impact of Concomitant Medication Use on Patient Eligibility for Phase I Cancer Clinical Trials
Mitesh J. Borad, Kelly K. Curtis, Hani M. Babiker, Martin Benjamin, Raoul Tibes, Ramesh K. Ramanathan, Karen Wright, Amylou C. Dueck, Gayle Jameson, Daniel D. Von Hoff
J. Cancer 2012; 3: 345-353. doi:10.7150/jca.4714
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Heterogeneity of p53-pathway Protein Expression in Chemosensitive Chronic Lymphocytic Leukemia: A Pilot Study
Michael J Groves, Stephanie F MacCallum, Michael T Boylan, Sally Haydock, Joan Cunningham, Keith Gelly, Duncan Gowans, Ron Kerr, Philip J Coates, Sudhir Tauro
J. Cancer 2012; 3: 354-361. doi:10.7150/jca.4813
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Sequential Therapy with Gemcitabine and Carboplatin Followed by Paclitaxel as First Line Treatment for Advanced Urothelial Cancer
Joseph G Kattan, Celine Y Boutros, Fadi S Farhat, Georges Y Chahine, Khaled M Musallam, Marwan G Ghosn
J. Cancer 2012; 3: 362-368. doi:10.7150/jca.4224
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Prognostic Value of EMT-Circulating Tumor Cells in Metastatic Breast Cancer Patients Undergoing High-Dose Chemotherapy with Autologous Hematopoietic Stem Cell Transplantation
Michal Mego, Hui Gao, Bang-Ning Lee, Evan N. Cohen, Sanda Tin, Antonio Giordano, Qiong Wu, Ping Liu, Yago Nieto, Richard E. Champlin, Gabriel N. Hortobagyi, Massimo Cristofanilli, Naoto T. Ueno, James M. Reuben
J. Cancer 2012; 3: 369-380. doi:10.7150/jca.5111
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
N-cadherin Expression in Testicular Germ Cell and Gonadal Stromal Tumors
Daniel J. Heidenberg, Joel H. Barton, Denise Young, Michael Grinkemeyer, Isabell A. Sesterhenn
J. Cancer 2012; 3: 381-389. doi:10.7150/jca.5017
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Promising Urinary Protein Biomarkers for the Early Detection of Hepatocellular Carcinoma among High-Risk Hepatitis C Virus Egyptian Patients
Moemen AK Abdalla, Yousef Haj-Ahmad
J. Cancer 2012; 3: 390-403. doi:10.7150/jca.4280
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Advances in Gas Chromatographic Methods for the Identification of Biomarkers in Cancer
Konstantinos A. Kouremenos, Mikael Johansson, Philip J. Marriott
J. Cancer 2012; 3: 404-420. doi:10.7150/jca.4956
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Prognostic Value of Proliferation Markers: Immunohistochemical Ki-67 Expression and Cytometric S-Phase Fraction of Women with Breast Cancer in Libya
Eramah Ermiah, Abdelbaset Buhmeida, Fathi Abdalla, Ben Romdhane Khaled, Nada Salem, Seppo Pyrhönen, Yrjö Collan
J. Cancer 2012; 3: 421-431. doi:10.7150/jca.4944
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Cell-free Circulating miRNA Biomarkers in Cancer
Meng-Hsuan Mo, Liang Chen, Yebo Fu, Wendy Wang, Sidney W. Fu
J. Cancer 2012; 3: 432-448. doi:10.7150/jca.4919
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Primary Anorectal Melanoma: An Update
P Carcoforo, M.T Raiji, G.M Palini, M Pedriali, U Maestroni, G Soliani, A Detroia, M.V Zanzi, A.L Manna, J.G Crompton, R.C Langan, A Stojadinovic, I Avital
J. Cancer 2012; 3: 449-453. doi:10.7150/jca.5187
[Abstract] [Full text] [PDF] [PubMed] [PMC]