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Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
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Research Paper
Decoding Somatic Driver Gene Mutations and Affected Signaling Pathways in Human Medulloblastoma Subgroups
Charles J. Robbins, Mayassa J. Bou-Dargham, Kevin Sanchez, Matthew C. Rosen, Qing-Xiang Amy Sang
J. Cancer 2018; 9(24): 4596-4610. doi:10.7150/jca.27993
[Abstract] [Full text] [PDF]

Research Paper
Overexpression of FNDC1 in Gastric Cancer and its Prognostic Significance
Jun Ren, Gengming Niu, Xin Wang, Tao Song, Zhiqing Hu, Chongwei Ke
J. Cancer 2018; 9(24): 4586-4595. doi:10.7150/jca.27672
[Abstract] [Full text] [PDF]

Research Paper
Knockout of MTF1 Inhibits the Epithelial to Mesenchymal Transition in Ovarian Cancer Cells
Liang Ji, Guannan Zhao, Peng Zhang, Wenying Huo, Peixin Dong, Hidemichi Watari, Limin Jia, Lawrence M Pfeffer, Junming Yue, Jinhua Zheng
J. Cancer 2018; 9(24): 4578-4585. doi:10.7150/jca.28040
[Abstract] [Full text] [PDF]

Research Paper
Systematic Analysis of Gene Expression Alteration and Co-Expression Network of Eukaryotic Initiation Factor 4A-3 in Cancer
Yan Lin, Jinyan Zhang, Junying Cai, Rong Liang, Guoying Chen, Gang Qin, Xueqiong Han, Chunling Yuan, Zhihui Liu, Yongqiang Li, Donghua Zou, Yingwei Mao
J. Cancer 2018; 9(24): 4568-4577. doi:10.7150/jca.27655
[Abstract] [Full text] [PDF]

Research Paper
Efficacy and Safety of Ipilimumab plus Chemotherapy for Advanced Lung Cancer: A Systematic Review and Meta-Analysis
Hongman Zhang, Jie Shen, Lilan Yi, Wei Zhang, Peng Luo, Jian Zhang
J. Cancer 2018; 9(23): 4556-4567. doi:10.7150/jca.27368
[Abstract] [Full text] [PDF]

Research Paper
Prognosis Analysis of Histone Deacetylases mRNA Expression in Ovarian Cancer Patients
Lulu Zhou, Xiaohui Xu, Hailing Liu, Xiaoli Hu, Wenwen Zhang, Miaomiao Ye, Xueqiong Zhu
J. Cancer 2018; 9(23): 4547-4555. doi:10.7150/jca.26780
[Abstract] [Full text] [PDF]

Research Paper
The Combination of Omega-3 Stearidonic Acid and Docetaxel Enhances Cell Death over Docetaxel Alone in Human Prostate Cancer Cells
Mahmoud Mansour, Sabrina van Ginkel, John C. Dennis, Brandon Mason, Isra Elhussin, Kodye Abbott, Satyanarayana R Pondugula, Temesgen Samuel, Edward Morrison
J. Cancer 2018; 9(23): 4536-4546. doi:10.7150/jca.26681
[Abstract] [Full text] [PDF]

Research Paper
Oxymatrine Synergistically Potentiates the Antitumor Effects of Cisplatin in Human Gastric Cancer Cells
Yan Liu, Lei Qin, Tingting Bi, Wei Dai, Wei Liu, Quangen Gao, Genhai Shen
J. Cancer 2018; 9(23): 4527-4535. doi:10.7150/jca.28532
[Abstract] [Full text] [PDF]

Research Paper
Functional Polymorphisms in hOGG1 Gene and Neuroblastoma Risk in Chinese Children
Yi-Zhen Wang, Zhen-Jian Zhuo, Yuan Fang, Lin Li, Jiao Zhang, Jing He, Xue-Mei Wu
J. Cancer 2018; 9(23): 4521-4526. doi:10.7150/jca.27983
[Abstract] [Full text] [PDF]

Research Paper
The Efficacy and Safety of Anti-epidermal Growth Factor Receptor Monoclonal Antibodies in Nasopharyngeal Carcinoma: Literature-based Meta-analyses
Liang Peng, Ze-Long Liu, Cheng Xu, Ling-Long Tang, Xu Liu, Ai-Hua Lin, Ying Sun, Yu-Pei Chen, Jun Ma
J. Cancer 2018; 9(23): 4510-4520. doi:10.7150/jca.27611
[Abstract] [Full text] [PDF]

Research Paper
Ribonucleotide Reductase Inhibitor 3-AP Induces Oncogenic Virus Infected Cell Death and Represses Tumor Growth
Lu Dai, Jungang Chen, Yueyu Cao, Luis Del Valle, Zhiqiang Qin
J. Cancer 2018; 9(23): 4503-4509. doi:10.7150/jca.27437
[Abstract] [Full text] [PDF]

Research Paper
GFAP expression is influenced by astrocytoma grade and rs2070935 polymorphism
Mantas Sereika, Ruta Urbanaviciute, Arimantas Tamasauskas, Daina Skiriute, Paulina Vaitkiene
J. Cancer 2018; 9(23): 4496-4502. doi:10.7150/jca.26769
[Abstract] [Full text] [PDF]

Research Paper
Identification of Five Genes as a Potential Biomarker for Predicting Progress and Prognosis in Adrenocortical Carcinoma
He Xiao, Deqiang Xu, Ping Chen, Guang Zeng, Xinghuan Wang, Xinhua Zhang
J. Cancer 2018; 9(23): 4484-4495. doi:10.7150/jca.26698
[Abstract] [Full text] [PDF]

Research Paper
Feasibility and Efficacy of Simultaneous Integrated Boost Intensity-modulated Radiation Therapy based on MRI-CT fusion in Patients with Brain Metastases of Non-small Cell Lung Cancer
Yinping Dong, Yanke Zhang, Tianyi Zhang, Min Fan, Jian Zhu, Baosheng Li, Wei Huang
J. Cancer 2018; 9(23): 4477-4483. doi:10.7150/jca.26547
[Abstract] [Full text] [PDF]

Research Paper
Identification of Grade-associated MicroRNAs in Brainstem Gliomas Based on Microarray Data
Xin Chen, Dezuo Dong, Changcun Pan, Cheng Xu, Yu Sun, Yibo Geng, Lu Kong, Xiong Xiao, Zitong Zhao, Wei Zhou, Lijie Huang, Yongmei Song, Liwei Zhang
J. Cancer 2018; 9(23): 4463-4476. doi:10.7150/jca.26417
[Abstract] [Full text] [PDF]

Research Paper
Tenascin-C Modulates Cell Cycle Progression to Enhance Tumour Cell Proliferation through AKT/FOXO1 Signalling in Pancreatic Cancer
Jun Cai, Wenli Lu, Shaoxia Du, Zhongkui Guo, Hui Wang, Wei Wei, Xiaohong Shen
J. Cancer 2018; 9(23): 4449-4462. doi:10.7150/jca.25926
[Abstract] [Full text] [PDF]

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