Editors-in-Chief:
Yan-Gao Man, MD., PhD., Co-Director, Laboratory of Proteomics and Protein Sciences, Veterans Affair Health System, Baltimore, MD, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...
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Journal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer.

Latest papers:

Research Paper
Comparison of FIB-4 index and aspartate aminotransferase to platelet ratio index on carcinogenesis in chronic hepatitis B treated with entecavir
Hiroki Nishikawa, Norihiro Nishijima, Hirayuki Enomoto, Azusa Sakamoto, Akihiro Nasu, Hideyuki Komekado, Takashi Nishimura, Ryuichi Kita, Toru Kimura, Hiroko Iijima, Shuhei Nishiguchi, Yukio Osaki
J. Cancer 2017; 8(2): 152-161. doi:10.7150/jca.16523
[Abstract] [Full text] [PDF]

Research Paper
Low Incidence along with Low mRNA Levels of EGFRvIII in Prostate and Colorectal Cancers Compared to Glioblastoma
Joanna Peciak, Wojciech J Stec, Cezary Treda, Magdalena Ksiazkiewicz, Karolina Janik, Marta Popeda, Maciej Smolarz, Kamila Rosiak, Krystyna Hulas-Bigoszewska, Waldemar Och, Piotr Rieske, Ewelina Stoczynska-Fidelus
J. Cancer 2017; 8(1): 146-151. doi:10.7150/jca.16108
[Abstract] [Full text] [PDF]

Short Research Communication
The Novel PIM1 Inhibitor NMS-P645 Reverses PIM1-Dependent Effects on TMPRSS2/ERG Positive Prostate Cancer Cells And Shows Anti-Proliferative Activity in Combination with PI3K Inhibition
Luca Mologni, Vera Magistroni, Francesco Casuscelli, Marisa Montemartini, Carlo Gambacorti-Passerini
J. Cancer 2017; 8(1): 140-145. doi:10.7150/jca.15838
[Abstract] [Full text] [PDF]

Research Paper
Proteins Involved in HER2 Signalling Pathway, Their Relations and Influence on Metastasis-Free Survival in HER2-Positive Breast Cancer Patients Treated with Trastuzumab in Adjuvant Setting
Agnieszka Adamczyk, Aleksandra Grela-Wojewoda, Małgorzata Domagała-Haduch, Aleksandra Ambicka, Agnieszka Harazin-Lechowska, Anna Janecka, Ida Cedrych, Kaja Majchrzyk, Anna Kruczak, Janusz Ryś, Joanna Niemiec
J. Cancer 2017; 8(1): 131-139. doi:10.7150/jca.16239
[Abstract] [Full text] [PDF]

Research Paper
Strong Correlation of Indoleamine 2,3-Dioxygenase 1 Expression with Basal-Like Phenotype and Increased Lymphocytic Infiltration in Triple-Negative Breast Cancer
Sewha Kim, Sanghui Park, Min Sun Cho, Woosung Lim, Byung-In Moon, Sun Hee Sung
J. Cancer 2017; 8(1): 124-130. doi:10.7150/jca.17437
[Abstract] [Full text] [PDF]

Research Paper
Worse Prognosis in Papillary, Compared to Tubular, Early Gastric Carcinoma
Huiping Yu, Cheng Fang, Lin Chen, Jiong Shi, Xianshan Fan, Xiaoping Zou, Qin Huang
J. Cancer 2017; 8(1): 117-123. doi:10.7150/jca.17326
[Abstract] [Full text] [PDF]

Research Paper
Association between expression of Carboxypeptidase 4 and stem cell markers and their clinical significance in liver cancer development
Lichao Sun, Chunguang Guo, Joseph Burnett, Jian Pan, Zhihua Yang, Yuliang Ran, Duxin Sun
J. Cancer 2017; 8(1): 111-116. doi:10.7150/jca.17060
[Abstract] [Full text] [PDF]

Research Paper
Clinical Significance of Folate Receptor-positive Circulating Tumor Cells Detected by Ligand-targeted Polymerase Chain Reaction in Lung Cancer
Lin Wang, Chuanyong Wu, Lihua Qiao, Wenjun Yu, Qiaomei Guo, Mingna Zhao, Guohua Yang, Hang Zhao, Jiatao Lou
J. Cancer 2017; 8(1): 104-110. doi:10.7150/jca.16856
[Abstract] [Full text] [PDF]

Research Paper
High Expression of LINC01420 indicates an unfavorable prognosis and modulates cell migration and invasion in nasopharyngeal carcinoma
Liting Yang, Yanyan Tang, Yi He, Yumin Wang, Yu Lian, Fang Xiong, Lei Shi, Shanshan Zhang, Zhaojian Gong, Yujuan Zhou, Qianjin Liao, Ming Zhou, Xiaoling Li, Wei Xiong, Yong Li, Guiyuan Li, Zhaoyang Zeng, Can Guo
J. Cancer 2017; 8(1): 97-103. doi:10.7150/jca.16819
[Abstract] [Full text] [PDF]

Review
Human-derived normal mesenchymal stem/stromal cells in anticancer therapies
Cheng Zhang, Shi-Jie Yang, Qin Wen, Jiang F Zhong, Xue-Lian Chen, Andres Stucky, Michael F Press, Xi Zhang
J. Cancer 2017; 8(1): 85-96. doi:10.7150/jca.16792
[Abstract] [Full text] [PDF]

Research Paper
Activation or suppression of the immune response mediators in biliary tract cancer (BTC) patients: a systematic review and meta-analysis
Ying Wang, Min Ding, Qian Zhang, Jinghan Wang, Xijing Yang, Fuping Zhou, Linfang Li, Zhengang Yuan, Huajun Jin, Qijun Qian
J. Cancer 2017; 8(1): 74-84. doi:10.7150/jca.16774
[Abstract] [Full text] [PDF]

Research Paper
Comparative analysis of Notch1 and Notch2 binding sites in the genome of BxPC3 pancreatic cancer cells
Hao Liu, Ping Zhou, Hong Lan, Jia Chen, Yu-xiang Zhang
J. Cancer 2017; 8(1): 65-73. doi:10.7150/jca.16739
[Abstract] [Full text] [PDF]

Research Paper
Lentiviral CRISPR/Cas9 vector mediated miR-21 gene editing inhibits the epithelial to mesenchymal transition in ovarian cancer cells
Wenying Huo, Guannan Zhao, Jinggang Yin, Xuan Ouyang, Yinan Wang, Chuanhe Yang, Baojing Wang, Peixin Dong, Zhixiang Wang, Hidemichi Watari, Edward Chaum, Lawrence M. Pfeffer, Junming Yue
J. Cancer 2017; 8(1): 57-64. doi:10.7150/jca.16723
[Abstract] [Full text] [PDF]

Research Paper
Identification of A Panel of Serum microRNAs as Biomarkers for Early Detection of Lung Adenocarcinoma
Shaogang Lv, Jian Xue, Chuanyong Wu, Lin Wang, Jing Wu, Shujun Xu, Xiaohui Liang, Jiatao Lou
J. Cancer 2017; 8(1): 48-56. doi:10.7150/jca.16644
[Abstract] [Full text] [PDF]

Research Paper
Epithelial-Mesenchymal Transition is Superior to Vessels-Encapsulate Tumor Cluster in Promoting Metastasis of Hepatocellular Carcinoma: a Morphological Evidence
Chuanchao He, Zhenyu Zhou, Hai Jiang, Zi Yin, Shiyu Meng, Jianlong Zhang, Pinbo Huang, Kang Xu, Lijuan Bian, Zhiyu Xiao, Jie Wang
J. Cancer 2017; 8(1): 39-47. doi:10.7150/jca.16736
[Abstract] [Full text] [PDF]

Research Paper
Research progress in the treatment of small cell lung cancer
Yan-fang Qiu, Zhi-gang Liu, Wen-juan Yang, Yu Zhao, Jiao Tang, Wei-zhi Tang, Yi Jin, Fang Li, Rui Zhong, Hui Wang
J. Cancer 2017; 8(1): 29-38. doi:10.7150/jca.16822
[Abstract] [Full text] [PDF]

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