Editors-in-Chief:
Yan-Gao Man, MD., PhD., Co-Director, Laboratory of Proteomics and Protein Sciences, Veterans Affair Health System, Baltimore, MD, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...
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Journal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer.


Research Paper
Optimal Modality for Detecting Distant Metastasis in Primary Nasopharyngeal Carcinoma during Initial Staging: A Systemic Review and Meta-analysis of 1774 Patients
Cheng Xu, Yuan Zhang, Liang Peng, Xu Liu, Wen-Fei Li, Ying Sun, Xu Zhang, Xiao-Ping Lin, Qing Liu, Jun Ma
J. Cancer 2017; 8(7): 1238-1248. doi:10.7150/jca.18361
[Abstract] [Full text] [PDF]

Research Paper
The Prognostic Value of Tyrosine Kinase SRC Expression in Locally Advanced Rectal Cancer
Felix Rühlmann, Manuel Nietert, Thilo Sprenger, Hendrik A. Wolff, Kia Homayounfar, Peter Middel, Hanibal Bohnenberger, Tim Beissbarth, B. Michael Ghadimi, Torsten Liersch, Lena-Christin Conradi
J. Cancer 2017; 8(7): 1229-1237. doi:10.7150/jca.16980
[Abstract] [Full text] [PDF]

Research Paper
PSA and Prostate Health Index based prostate cancer screening in a hereditary migration complicated population: implications in precision diagnosis
Mariyam Akizhanova, Elzira E. Iskakova, Valdemir Kim, Xiao Wang, Roman Kogay, Aiym Turebayeva, Qinglei Sun, Ting Zheng, Shenghui Wu, Lixia Miao, Yingqiu Xie
J. Cancer 2017; 8(7): 1223-1228. doi:10.7150/jca.18012
[Abstract] [Full text] [PDF]

Research Paper
Elevated preoperative neutrophil-to-lymphocyte ratio can predict poor survival in early stage gastric cancer patients receiving radical gastrectomy: The Fujian prospective investigation of cancer (FIESTA) study
Dan Hu, Hejun Zhang, Xiandong Lin, Gang Chen, Chao Li, Binying Liang, Yan Chen, Zhaolei Cui, Feng Peng, Xiongwei Zheng, Wenquan Niu
J. Cancer 2017; 8(7): 1214-1222. doi:10.7150/jca.18707
[Abstract] [Full text] [PDF]

Review
E2F8 is a Potential Therapeutic Target for Hepatocellular Carcinoma
Yi Lv, Jia Xiao, Jing Liu, Feiyue Xing
J. Cancer 2017; 8(7): 1205-1213. doi:10.7150/jca.18255
[Abstract] [Full text] [PDF]

Research Paper
High Expression of Aldolase B Confers a Poor Prognosis for Rectal Cancer Patients Receiving Neoadjuvant Chemoradiotherapy
Yu-Feng Tian, Pei-Ling Hsieh, Ching-Yih Lin, Ding-Ping Sun, Ming-Jen Sheu, Ching-Chieh Yang, Li-Ching Lin, Hong-Lin He, Julia Solórzano, Chien-Feng Li, I-Wei Chang
J. Cancer 2017; 8(7): 1197-1204. doi:10.7150/jca.18197
[Abstract] [Full text] [PDF]

Research Paper
Chemoresistance of colorectal cancer to 5-fluorouracil is associated with silencing of the BNIP3 gene through aberrant methylation
Jianming He, Li Pei, Heng Jiang, Weiwen Yang, Jianfang Chen, Houjie Liang
J. Cancer 2017; 8(7): 1187-1196. doi:10.7150/jca.18171
[Abstract] [Full text] [PDF]

Research Paper
The Role of Adjuvant Chemotherapy for Colorectal Liver Metastasectomy after Pre-Operative Chemotherapy: Is the Treatment Worthwhile?
Yun Wang, Zhi-qiang Wang, Feng-hua Wang, Yun-fei Yuan, Bin-kui Li, Pei-rong Ding, Gong Chen, Xiao-jun Wu, Zhen-hai Lu, Zhi-zhong Pan, De-sen Wan, Peng Sun, Shu-mei Yan, Rui-hua Xu, Yu-hong Li
J. Cancer 2017; 8(7): 1179-1186. doi:10.7150/jca.18091
[Abstract] [Full text] [PDF]

Research Paper
PET of HER2 Expression with a Novel 18FAl Labeled Affibody
Yuping Xu, Zhicheng Bai, Qianhuan Huang, Yunyun Pan, Donghui Pan, Lizhen Wang, Junjie Yan, Xinyu Wang, Runlin Yang, Min Yang
J. Cancer 2017; 8(7): 1170-1178. doi:10.7150/jca.18070
[Abstract] [Full text] [PDF]

Research Paper
Association between SNPs in Long Non-coding RNAs and the Risk of Female Breast Cancer in a Chinese Population
Tao Xu, Xiu-Xiu Hu, Xiang-Xiang Liu, Han-Jin Wang, Kang Lin, Yu-Qin Pan, Hui-Ling Sun, Hong-Xin Peng, Xiao-Xiang Chen, Shu-Kui Wang, Bang-Shun He
J. Cancer 2017; 8(7): 1162-1169. doi:10.7150/jca.18055
[Abstract] [Full text] [PDF]

Research Paper
Overexpression of Mitochondrial GTPase MFN2 Represents a Negative Prognostic Marker in Human Gastric Cancer and Its Inhibition Exerts Anti-Cancer Effects
Chia-Lang Fang, Ding-Ping Sun, Han-Kun Chen, Chih-Chan Lin, Shih-Ting Hung, Yih-Huei Uen, Kai-Yuan Lin
J. Cancer 2017; 8(7): 1153-1161. doi:10.7150/jca.17986
[Abstract] [Full text] [PDF]

Research Paper
Isolation and Identification of miRNAs in exosomes derived from serum of colon cancer patients
Lei Zhao, Jing Yu, Jing Wang, Huihui Li, Juanjuan Che, Bangwei Cao
J. Cancer 2017; 8(7): 1145-1152. doi:10.7150/jca.18026
[Abstract] [Full text] [PDF]

Research Paper
Impact of CD44 expression on radiation response for bladder cancer
Chun-Te Wu, Wei-Yu Lin, Ying-Hsu Chang, Wen-Cheng Chen, Miao-Fen Chen
J. Cancer 2017; 8(7): 1137-1144. doi:10.7150/jca.18297
[Abstract] [Full text] [PDF]

Research Paper
Knockdown of COPS3 Inhibits Lung Cancer Tumor Growth in Nude Mice by Blocking Cell Cycle Progression
Jianan Pang, Xu Yan, He Cao, Lei Qian, Hua He, Huimin Tian, Fujun Han, Guanjun Wang, Xiao Chen, Yuguang Zhao, Ji-Fan Hu, Jiuwei Cui
J. Cancer 2017; 8(7): 1129-1136. doi:10.7150/jca.16201
[Abstract] [Full text] [PDF]

Short Research Communication
Aberrant Cx43 Expression and Mislocalization in Metastatic Human Melanomas
Katanya C. Alaga, Melissa Crawford, Lina Dagnino, Dale W. Laird
J. Cancer 2017; 8(7): 1123-1128. doi:10.7150/jca.18569
[Abstract] [Full text] [PDF]

Research Paper
A Combined ULBP2 and SEMA5A Expression Signature as a Prognostic and Predictive Biomarker for Colon Cancer
Secil Demirkol, Ismail Gomceli, Murat Isbilen, Baris Emre Dayanc, Mesut Tez, Erdal Birol Bostanci, Nesrin Turhan, Musa Akoglu, Ezgi Ozyerli, Sevi Durdu, Ozlen Konu, Aviram Nissan, Mithat Gonen, Ali Osmay Gure
J. Cancer 2017; 8(7): 1113-1122. doi:10.7150/jca.17872
[Abstract] [Full text] [PDF]

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