Editors-in-Chief:
Yan-Gao Man, MD., PhD., Co-Director, Laboratory of Proteomics and Protein Sciences, Veterans Affair Health System, Baltimore, MD, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...
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Journal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer.


Research Paper
Esophageal Cancer in Israel has Unique Clinico-Pathological Features: A Retrospective Study
Michal Sarfaty, Esty Lankry, Assaf Moore, Noga Kurman, Ofer Purim, Yulia Kundel, Irit Ben-Aharon, Gali Perl, Olga Ulitsky, Noa Gordon, Aaron Sulkes, Nikolai Menasherov, Hanoch Kashtan, Baruch Brenner
J. Cancer 2017; 8(13): 2417-2423. doi:10.7150/jca.19210
[Abstract] [Full text] [PDF]

Research Paper
DNA-dependent protein kinase catalytic subunit functions in metastasis and influences survival in advanced-stage laryngeal squamous cell carcinoma
Sha-sha He, Yong Chen, Xiao-ming Shen, Hong-zhi Wang, Peng Sun, Jun Dong, Gui-fang Guo, Ju-gao Chen, Liang-ping Xia, Pei-li Hu, Hui-juan Qiu, Shou-sheng Liu, Yi-xin Zhou, Wei Wang, Wei-han Hu, Xiu-yu Cai
J. Cancer 2017; 8(12): 2410-2416. doi:10.7150/jca.20069
[Abstract] [Full text] [PDF]

Research Paper
Association of HLA-DRB1, HLA-DQB1 Polymorphisms with HPV 16 E6 Variants among Young Cervical Cancer Patients in China
Yan Hu, Jin-Ze Wu, Hua Zhu, Sheng-Hui Zhang, Yan-Ying Zhu, Yi-Yao Wu, Ci-Xia Shuai
J. Cancer 2017; 8(12): 2401-2409. doi:10.7150/jca.19809
[Abstract] [Full text] [PDF]

Research Paper
Predictive Value of Primary Tumor Site for Loco-regional Recurrence in Early Breast Cancer Patients with One to Three Positive Axillary Lymphadenophy
Shaoqing Niu, Ge Wen, Yufeng Ren, Yiyang Li, Lingling Feng, Chengtao Wang, Xiaobo Huang, Bixiu Wen, Yujing Zhang
J. Cancer 2017; 8(12): 2394-2400. doi:10.7150/jca.19722
[Abstract] [Full text] [PDF]

Research Paper
Interferon-α Promotes the Expression of Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma
Hailong Ma, Shufang Jin, Wenyi Yang, Zhuowei Tian, Shuli Liu, Yang Wang, Ge Zhou, Mei Zhao, Shalva Gvetadze, Zhiyuan Zhang, Jingzhou Hu
J. Cancer 2017; 8(12): 2384-2393. doi:10.7150/jca.19486
[Abstract] [Full text] [PDF]

Review
VSV based virotherapy in ovarian cancer: the past, the present and …future?
Beata Urszula Orzechowska, Marcin Jędryka, Katarzyna Zwolińska, Rafał Matkowski
J. Cancer 2017; 8(12): 2369-2383. doi:10.7150/jca.19473
[Abstract] [Full text] [PDF]

Research Paper
MicroRNA-204-5p inhibits invasion and metastasis of laryngeal squamous cell carcinoma by suppressing forkhead box C1
Wei Gao, Yongyan Wu, Xiaoling He, Chunming Zhang, Meixia Zhu, Bo Chen, Qingqing Liu, Xukuan Qu, Weiyan Li, Shuxin Wen, Binquan Wang
J. Cancer 2017; 8(12): 2356-2368. doi:10.7150/jca.19470
[Abstract] [Full text] [PDF]

Research Paper
Development and Validation of a Serum Biomarker Panel for the Detection of Esophageal Squamous Cell Carcinoma through RNA Transcriptome Sequencing
Shan Xing, Xin Zheng, Li-Qiang Wei, Shi-Jian Song, Dan Liu, Ning Xue, Xiao-Min Liu, Mian-Tao Wu, Qian Zhong, Chu-Mei Huang, Mu-Sheng Zeng, Wan-Li Liu
J. Cancer 2017; 8(12): 2346-2355. doi:10.7150/jca.19465
[Abstract] [Full text] [PDF]

Research Paper
Elevated expression of Derlin-1 associates with unfavorable survival time of squamous cell carcinoma of the head and neck and promotes its malignance
Leiming Pi, Gangcai Zhu, Li She, Ming Wei, Guancheng Liu, Changhan Chen, Di Hu, Fusen Peng, Haolei Tan, Yong Liu, Donghai Huang, Yongquan Tian, Xin Zhang
J. Cancer 2017; 8(12): 2336-2345. doi:10.7150/jca.19411
[Abstract] [Full text] [PDF]

Research Paper
Impact of Detection Method and Accompanying Ductal Carcinoma in Situ on Prognosis of T1a,bN0 Breast Cancer
Shih-Che Shen, Shir-Hwa Ueng, Chan-Keng Yang, Chi-Chang Yu, Yung-Feng Lo, Hsien-Kun Chang, Yung-Chang Lin, Shin-Cheh Chen
J. Cancer 2017; 8(12): 2328-2335. doi:10.7150/jca.19293
[Abstract] [Full text] [PDF]

Review
Epithelial-mesenchymal transition: potential regulator of ABC transporters in tumor progression
Zong-Sheng Jiang, Yan-Zi Sun, Shao-Ming Wang, Jun-Shan Ruan
J. Cancer 2017; 8(12): 2319-2327. doi:10.7150/jca.19079
[Abstract] [Full text] [PDF]

Research Paper
Pattern of distant extrahepatic metastases in primary liver cancer: a SEER based study
Wenrui Wu, Xingkang He, Dewi Andayani, Liya Yang, Jianzhong Ye, Yating Li, Yanfei Chen, Lanjuan Li
J. Cancer 2017; 8(12): 2312-2318. doi:10.7150/jca.19056
[Abstract] [Full text] [PDF]

Research Paper
Identification of Transcription Factor YY1 as a Regulator of a Prostate Cancer-Specific Pathway Using Proteomic Analysis
Arum Park, Jiyeong Lee, Sora Mun, Doo Jin Kim, Byung Heun Cha, Kyong Tae Moon, Tag Keun Yoo, Hee-Gyoo Kang
J. Cancer 2017; 8(12): 2303-2311. doi:10.7150/jca.19036
[Abstract] [Full text] [PDF]

Research Paper
Alcohol Consumption and Lung Cancer According to Ile349Val Polymorphism in ADH3 Gene: Beyond the Tobacco Smoking Effect
Ana Fernández-Somoano, Sara M Álvarez-Avellón, Ana Souto-García, Jesús Vioque, Eva M Navarrete-Muñoz, Adonina Tardón
J. Cancer 2017; 8(12): 2296-2302. doi:10.7150/jca.18853
[Abstract] [Full text] [PDF]

Research Paper
Silencing of HJURP induces dysregulation of cell cycle and ROS metabolism in bladder cancer cells via PPARγ-SIRT1 feedback loop
Rui Cao, Gang Wang, Kaiyu Qian, Liang Chen, Guofeng Qian, Conghua Xie, Han C. Dan, Wei Jiang, Min Wu, Chin-Lee Wu, Yu Xiao, Xinghuan Wang
J. Cancer 2017; 8(12): 2282-2295. doi:10.7150/jca.19967
[Abstract] [Full text] [PDF]

Research Paper
Tat-interactive Protein-60KDA (TIP60) Regulates the Tumorigenesis of Lung Cancer In Vitro
Yang Yang, Jian Sun, Ting Chen, Zengyue Tao, Xianwei Zhang, Feng Tian, Xiao Zhou, Daru Lu
J. Cancer 2017; 8(12): 2277-2281. doi:10.7150/jca.19677
[Abstract] [Full text] [PDF]

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