Editors-in-Chief:
Yan-Gao Man, MD., PhD., Co-Director, Laboratory of Proteomics and Protein Sciences, Veterans Affair Health System, Baltimore, MD, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
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Research Paper
Aqueous Huaier Extract Suppresses Gastric Cancer Metastasis and Epithelial to Mesenchymal Transition by Targeting Twist
Zhiyuan Xu, Guowei Zheng, Yiping Wang, Chunli Zhang, Jianfa Yu, Fei Teng, Hang Lv, Xiangdong Cheng
J. Cancer 2017; 8(18): 3876-3886. doi:10.7150/jca.20380
[Abstract] [Full text] [PDF]

Research Paper
Clinical Significance of CD163+ and CD68+ Tumor-associated Macrophages in High-risk HPV-related Cervical Cancer
Xiao-Jing Chen, Ling-Fei Han, Xiang-Guang Wu, Wen-Fei Wei, Lan-Fang Wu, Hong-Yan Yi, Rui-Ming Yan, Xiang-yang Bai, Mei Zhong, Yan-hong Yu, Li Liang, Wei Wang
J. Cancer 2017; 8(18): 3868-3875. doi:10.7150/jca.21444
[Abstract] [Full text] [PDF]

Research Paper
Preoperative Albumin-Bilirubin Score for Postoperative Solitary Hepatocellular Carcinoma within the Milan Criteria and Child-Pugh A Cirrhosis
Zhao-Ru Dong, Jie Zou, Dong Sun, Guo-Ming Shi, Ai-Wu Ke, Jia-Bin Cai, Hui-Chuan Sun, Shuang-Jian Qiu, Tao Li, Jian Zhou, Xu-Ting Zhi, Jia Fan
J. Cancer 2017; 8(18): 3862-3867. doi:10.7150/jca.21313
[Abstract] [Full text] [PDF]

Review
Roles of microRNAs in the resistance to platinum based chemotherapy in the non-small cell lung cancer
Hongjing Zang, Jianlun Peng, Weiyuan Wang, Songqing Fan
J. Cancer 2017; 8(18): 3856-3861. doi:10.7150/jca.21267
[Abstract] [Full text] [PDF]

Research Paper
Comparable Survival between Additional Radiotherapy and Local Surgery in Occult Breast Cancer after Axillary Lymph Node Dissection: A Population-based Analysis
San-Gang Wu, Wen-Wen Zhang, Jia-Yuan Sun, Feng-Yan Li, Huan-Xin Lin, Yong-Xiong Chen, Zhen-Yu He
J. Cancer 2017; 8(18): 3849-3855. doi:10.7150/jca.21217
[Abstract] [Full text] [PDF]

Research Paper
The Predictive and Prognostic Role of Stromal Tumor-infiltrating Lymphocytes in HER2-positive Breast Cancer with Trastuzumab-based Treatment: a Meta-analysis and Systematic Review
Tao Xu, Bang-Shun He, Xiang-Xiang Liu, Xiu-Xiu Hu, Kang Lin, Yu-Qin Pan, Hui-Ling Sun, Hong-Xin Peng, Xiao-Xiang Chen, Shu-Kui Wang
J. Cancer 2017; 8(18): 3838-3848. doi:10.7150/jca.21051
[Abstract] [Full text] [PDF]

Research Paper
Ki67 Proliferation Index as a Histopathological Predictive and Prognostic Parameter of Oral Mucosal Melanoma in Patients without Distant Metastases
Xuhui Ma, Yunteng Wu, Tian Zhang, Hao Song, Houyu Jv, Wei Guo, Guoxin Ren
J. Cancer 2017; 8(18): 3828-3837. doi:10.7150/jca.20935
[Abstract] [Full text] [PDF]

Research Paper
Overexpression of SMOC2 Attenuates the Tumorigenicity of Hepatocellular Carcinoma Cells and Is Associated With a Positive Postoperative Prognosis in Human Hepatocellular Carcinoma
Xu-Qiong Huang, Zi-Qi Zhou, Xiao-Fei Zhang, Chang-Long Chen, Yan Tang, Qian Zhu, Jian-Hua Zhang, Jian-Chuan Xia
J. Cancer 2017; 8(18): 3812-3827. doi:10.7150/jca.20775
[Abstract] [Full text] [PDF]

Research Paper
LncRNA MALAT1 Inhibits Apoptosis and Promotes Invasion by Antagonizing miR-125b in Bladder Cancer Cells
Haibiao Xie, Xinhui Liao, Zhicong Chen, Yuan Fang, Anbang He, Yucheng Zhong, Qunjun Gao, Huizhong Xiao, Jianfa Li, Weiren Huang, Yuchen Liu
J. Cancer 2017; 8(18): 3803-3811. doi:10.7150/jca.21228
[Abstract] [Full text] [PDF]

Research Paper
New Clinical Features and Dosimetric Predictor Identification for Symptomatic Radiation Pneumonitis after Tangential Irradiation in Breast Cancer Patients
Ge Wen, Yu-Ting Tan, Xiao-Wen Lan, Zhi-Chun He, Jiang-Hua Huang, Jun-Tian Shi, Xiao Lin, Xiao-Bo Huang
J. Cancer 2017; 8(18): 3795-3802. doi:10.7150/jca.21158
[Abstract] [Full text] [PDF]

Research Paper
Polymorphisms of CCNB1 Associated With the Clinical Outcomes of Platinum-Based Chemotherapy in Chinese NSCLC Patients
Di Liu, Wen Xu, Xi Ding, Yang Yang, Bo Su, Ke Fei
J. Cancer 2017; 8(18): 3785-3794. doi:10.7150/jca.21151
[Abstract] [Full text] [PDF]

Research Paper
Combined Inhibitions of Glycolysis and AKT/autophagy Can Overcome Resistance to EGFR-targeted Therapy of Lung Cancer
Mingtong Ye, Sufan Wang, Ting Wan, Rui Jiang, Yun Qiu, Lei Pei, Nengzhi Pang, Yuanling Huang, Yufeng Huang, Zhenfeng Zhang, Lili Yang
J. Cancer 2017; 8(18): 3774-3784. doi:10.7150/jca.21035
[Abstract] [Full text] [PDF]

Research Paper
ITGBL1 Predicts a Poor Prognosis and Correlates EMT Phenotype in Gastric Cancer
Rongkun Li, Chun Zhuang, Shuheng Jiang, Nan Du, Wenyi Zhao, Lin Tu, Hui Cao, Zhigang Zhang, Xiaofei Chen
J. Cancer 2017; 8(18): 3764-3773. doi:10.7150/jca.20900
[Abstract] [Full text] [PDF]

Research Paper
A nomogram based on phosphorylated AKT1 for predicting locoregional recurrence in patients with oesophageal squamous cell carcinoma
Weiwei Yu, Li Chu, Kuaile Zhao, Haiquan Chen, Jiaqing Xiang, Yawei Zhang, Hecheng Li, Weixin Zhao, Menghong Sun, Qiao Wei, Xiaolong Fu, Congying Xie, Zhengfei Zhu
J. Cancer 2017; 8(18): 3755-3763. doi:10.7150/jca.20828
[Abstract] [Full text] [PDF]

Research Paper
Insufficient Radiofrequency Ablation Treated Hepatocellular Carcinoma Cells Promote Metastasis by Up-Regulation ITGB3
Ning Zhang, Dening Ma, Lu Wang, Xiaodong Zhu, Qi Pan, Yiming Zhao, Weiping Zhu, Jiamin Zhou, Longrong Wang, Zongtao Chai, Jianyang Ao, Huichuan Sun, Zhaoyou Tang
J. Cancer 2017; 8(18): 3742-3754. doi:10.7150/jca.20816
[Abstract] [Full text] [PDF]

Research Paper
Galectin-1 promotes tumor progression via NF-κB signaling pathway in epithelial ovarian cancer
Le Chen, Ying Yao, Lijuan Sun, Jie Tang
J. Cancer 2017; 8(18): 3733-3741. doi:10.7150/jca.20814
[Abstract] [Full text] [PDF]

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