Editors-in-Chief:
Yan-Gao Man, MD., PhD., Co-Director, Laboratory of Proteomics and Protein Sciences, Veterans Affair Health System, Baltimore, MD, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...
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Journal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer.


Research Paper
Upregulated long non-coding RNA LINC00152 expression is associated with progression and poor prognosis of tongue squamous cell carcinoma
Jianjun Yu, Yan Liu, Can Guo, Shanshan Zhang, Zhaojian Gong, Yanyan Tang, Liting Yang, Yi He, Yu Lian, Xiayu Li, Hao Deng, Qianjin Liao, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng, Wei Xiong, Xinming Yang
J. Cancer 2017; 8(4): 523-530. doi:10.7150/jca.17510
[Abstract] [Full text] [PDF]

Review
Molecular Subtyping of Pancreatic Cancer: Translating Genomics and Transcriptomics into the Clinic
Yongxing Du, Bangbo Zhao, Ziwen Liu, Xiaoxia Ren, Wenjing Zhao, Zongze Li, Lei You, Yupei Zhao
J. Cancer 2017; 8(4): 513-522. doi:10.7150/jca.17622
[Abstract] [Full text] [PDF]

Research Paper
Efficacy of Cabazitaxel Treatment in Metastatic Castration Resistant Prostate Cancer in Second and Later Lines. An Experience from Two German Centers
Stefanie Zschäbitz, Sonia Vallet, Boris Hadaschik, Daniel Debatin, Stefan Fuxius, Andreas Karcher, Sascha Pahernik, Cathleen Spath, Stefan Duensing, Dirk Jäger, Markus Hohenfellner, Carsten Grüllich
J. Cancer 2017; 8(4): 507-512. doi:10.7150/jca.17644
[Abstract] [Full text] [PDF]

Research Paper
Identification and characterization of CD133+CD44+ cancer stem cells from human laryngeal squamous cell carcinoma cell lines
Jue Wang, Yongyan Wu, Wei Gao, Fei Li, Yunfeng Bo, Meixia Zhu, Rong Fu, Qingqing Liu, Shuxin Wen, Binquan Wang
J. Cancer 2017; 8(3): 497-506. doi:10.7150/jca.17444
[Abstract] [Full text] [PDF]

Research Paper
High Residual Tumor Rate for Early Breast Cancer Patients Receiving Vacuum-assisted Breast Biopsy
Xiao-Fang He, Feng Ye, Jia-Huai Wen, Shuai-Jie Li, Xiao-Jia Huang, Xiang-Sheng Xiao, Xiao-Ming Xie
J. Cancer 2017; 8(3): 490-496. doi:10.7150/jca.17305
[Abstract] [Full text] [PDF]

Research Paper
Identifying DCN and HSPD1 as Potential Biomarkers in Colon Cancer Using 2D-LC-MS/MS Combined with iTRAQ Technology
Guoqing Li, Maoyu Li, Xujun Liang, Zhefeng Xiao, Pengfei Zhang, Meiying Shao, Fang Peng, Yongheng Chen, Yuanyuan Li, Zhuchu Chen
J. Cancer 2017; 8(3): 479-489. doi:10.7150/jca.17192
[Abstract] [Full text] [PDF]

Research Paper
Daughter Cells and Erythroid Cells Budding from PGCCs and Their Clinicopathological Significances in Colorectal Cancer
Dan Zhang, Xiaoyun Yang, Zhengduo Yang, Fei Fei, Shuyuan Li, Jie Qu, Mingqing Zhang, Yuwei Li, Xipeng Zhang, Shiwu Zhang
J. Cancer 2017; 8(3): 469-478. doi:10.7150/jca.17012
[Abstract] [Full text] [PDF]

Research Paper
Epigenetic dysregulation of NKD2 is a valuable predictor assessing treatment outcome in acute myeloid leukemia
Xi-xi Li, Jing-dong Zhou, Ting-juan Zhang, Lei Yang, Xiang-mei Wen, Ji-chun Ma, Jing Yang, Zhi-hui Zhang, Jiang Lin, Jun Qian
J. Cancer 2017; 8(3): 460-468. doi:10.7150/jca.16914
[Abstract] [Full text] [PDF]

Research Paper
Changes in Disease Failure Risk of Nasopharyngeal Carcinoma over Time: Analysis of 749 Patients with Long-Term Follow-Up
Xu Liu, Ling-Long Tang, Xiao-Jing Du, Wen-Fei Li, Lei Chen, Guan-Qun Zhou, Rui Guo, Qing Liu, Ying Sun, Jun Ma
J. Cancer 2017; 8(3): 455-459. doi:10.7150/jca.17104
[Abstract] [Full text] [PDF]

Research Paper
The Role of GOLPH3L in the Prognosis and NACT response in Cervical Cancer
Yanling Feng, Fan He, Shumei Yan, He Huang, Qidan Huang, Ting Deng, Huini Wu, Bei Gao, Jihong Liu
J. Cancer 2017; 8(3): 443-454. doi:10.7150/jca.17096
[Abstract] [Full text] [PDF]

Research Paper
Plasma mRNA as liquid biopsy predicts chemo-sensitivity in advanced gastric cancer patients
Jie Shen, Weiwei Kong, Yuanna Wu, Haozhen Ren, Jia Wei, Yang Yang, Yan Yang, Lixia Yu, Wenxian Guan, Baorui Liu
J. Cancer 2017; 8(3): 434-442. doi:10.7150/jca.17369
[Abstract] [Full text] [PDF]

Research Paper
A nomogram for predicting the probability of recurrence in patients with carcinomas located in the ampulla of Vater
Keng-Hao Liu, Chih-Ho Hsu, Jun-Te Hsu, Chun-Yi Tsai, Yu-Yin Liu, Tsann-Long Hwang, Ta-Sen Yeh, Yu-Shin Hung, Wen-Chi Chou
J. Cancer 2017; 8(3): 425-433. doi:10.7150/jca.17315
[Abstract] [Full text] [PDF]

Research Paper
Pretreatment Alkaline Phosphatase and Epstein-Barr Virus DNA Predict Poor Prognosis and Response to Salvage Radiotherapy in Patients with Nasopharyngeal Carcinoma and Metachronous Bone-Only Metastasis
ShaSha He, Yan Wang, Hao Peng, Lin Yang, HaiYang Chen, ShaoBo Liang, LiXia Lu, Yong Chen
J. Cancer 2017; 8(3): 417-424. doi:10.7150/jca.17310
[Abstract] [Full text] [PDF]

Review
Nivolumab as Programmed Death-1 (PD-1) Inhibitor for Targeted Immunotherapy in Tumor
Liting Guo, Haijun Zhang, Baoan Chen
J. Cancer 2017; 8(3): 410-416. doi:10.7150/jca.17144
[Abstract] [Full text] [PDF]

Research Paper
Plasma Fibrinogen Correlates with Metastasis and is Associated with Prognosis in Human Nasopharyngeal Carcinoma
Sha-Sha He, Yan Wang, Lin Yang, Hai-Yang Chen, Shao-Bo Liang, Li-Xia Lu, Yong Chen
J. Cancer 2017; 8(3): 403-409. doi:10.7150/jca.17028
[Abstract] [Full text] [PDF]

Research Paper
Integrative Oncology Physician Consultations at a Comprehensive Cancer Center: Analysis of Demographic, Clinical and Patient Reported Outcomes
Gabriel Lopez, Jennifer McQuade, Lorenzo Cohen, Jane T Williams, Amy R Spelman, Bryan Fellman, Yisheng Li, Eduardo Bruera, Richard T Lee
J. Cancer 2017; 8(3): 395-402. doi:10.7150/jca.17506
[Abstract] [Full text] [PDF]

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