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Deregulated Wnt signaling initiates most cases of colorectal cancer (CRC). Butyrate, a product of dietary fiber, hyperactivates Wnt signaling, resulting in induction of CRC cell apoptosis, which may in part explain the protective action of fiber. Nonsense mediated decay (NMD) of mRNAs containing premature stop codons (PTCs) affects tumorigenesis and upregulates Wnt signaling in human embryonic stem cells. . More ...
Yes Associated Protein 1 (YAP) and Transcriptional coactivator with PDZ-Binding Motif (TAZ) have gained notoriety for their ability to drive tumor initiation and progression in a wide variety of cancers, including melanoma. YAP and TAZ act as drivers of melanoma through its interaction with the TEAD family of transcription factors. Verteporfin is a benzoporphyrin derivative that is used clinically for photodynamic treatment of macular degeneration. . More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
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Review
Nanotechnology in metastatic cancer treatment: Current Achievements and Future Research Trends
Diana Gonciar, Teodora Mocan, Cristian Tudor Matea, Claudiu Zdrehus, Ofelia Mosteanu, Lucian Mocan, Teodora Pop
J. Cancer 2019; 10(6): 1358-1369. doi:10.7150/jca.28394
[Abstract] [Full text] [PDF]

Research Paper
Prognostic impact of family history of cancer in Southern Chinese patients with esophageal squamous cell cancer
Zhen Su, Guo-Rong Zou, Yan-Ping Mao, Pu-Yun OuYang, Xiao-Long Cao, Fang-Yun Xie, Qun Li
J. Cancer 2019; 10(6): 1349-1357. doi:10.7150/jca.26511
[Abstract] [Full text] [PDF]

Research Paper
Increased circulating GrMyeloid-derived suppressor cells correlated with tumor burden and survival in locally advanced cervical cancer patient
Yun Liang, Bingjian Lü, Peng Zhao, Weiguo Lü
J. Cancer 2019; 10(6): 1341-1348. doi:10.7150/jca.29647
[Abstract] [Full text] [PDF]

Research Paper
Knockdown of long non-coding RNA SNHG5 inhibits malignant cellular phenotypes of glioma via Wnt/CTNNB1 signaling pathway
Xuanhao Hu, Yang Hong, Chao Shang
J. Cancer 2019; 10(5): 1333-1340. doi:10.7150/jca.29517
[Abstract] [Full text] [PDF]

Research Paper
Gender disparity in the survival of patients with primary myelodysplastic syndrome
Fangfang Wang, Jun Ni, Lei Wu, Ying Wang, Bin He, Duonan Yu
J. Cancer 2019; 10(5): 1325-1332. doi:10.7150/jca.28220
[Abstract] [Full text] [PDF]

Research Paper
High expression of Oct4 and Nanog predict poor prognosis in intrahepatic cholangiocarcinoma patients after curative resection
Mei-xia Zhang, Wei Gan, Chu-yu Jing, Su-su Zheng, Yong Yi, Juan Zhang, Xin Xu, Jia-jia Lin, Bo-heng Zhang, Shuang-jian Qiu
J. Cancer 2019; 10(5): 1313-1324. doi:10.7150/jca.28349
[Abstract] [Full text] [PDF]

Research Paper
Survival Benefit of Preoperative Versus Postoperative Radiotherapy in Metastatic Rectal Cancer Treated With Definitive Surgical Resection of Primary Tumor: A Population Based, Propensity Score-Matched Study
Dakui Luo, Qi Liu, Ji Zhu, Yanlei Ma, Sanjun Cai, Qingguo Li, Xinxiang Li
J. Cancer 2019; 10(5): 1307-1312. doi:10.7150/jca.28320
[Abstract] [Full text] [PDF]

Research Paper
O Blood Type Is Associated with Unfavorable Distant-metastasis-free Survival in Female Patients with Nasopharyngeal Carcinoma: A Retrospective Study of 2439 Patients from Epidemic Area
Guan-Nan Wang, Shu Zhou, Chen Chen, Hui Chang, Yalan Tao, Shan Liu, Xiao-Hui Wang, Wen-Wen Zhang, Yang Liu, Song-Ran Liu, Shi-Rong Ding, Xin Yang, Zheng-Qian Ye, Yi-Feng Gao, Yun-Fei Xia
J. Cancer 2019; 10(5): 1297-1306. doi:10.7150/jca.28372
[Abstract] [Full text] [PDF]

Research Paper
Lower Expression of Gelsolin in Colon Cancer and Its Diagnostic Value in Colon Cancer Patients
Zhuoyu Chen, Kaifei Li, Xiaofeng Yin, Haixia Li, Yao Li, Qiong Zhang, Haifang Wang, Yurong Qiu
J. Cancer 2019; 10(5): 1288-1296. doi:10.7150/jca.28529
[Abstract] [Full text] [PDF]

Research Paper
Antitumor activity of histone deacetylase inhibitor chidamide alone or in combination with epidermal growth factor receptor tyrosine kinase inhibitor icotinib in NSCLC
Ningning Zhang, Caixia Liang, Wenya Song, Dan Tao, Jiarui Yao, Shuai Wang, Li Ma, Yuankai Shi, Xiaohong Han
J. Cancer 2019; 10(5): 1275-1287. doi:10.7150/jca.28570
[Abstract] [Full text] [PDF]

Research Paper
Development and Validation of Nomograms Predictive of Axillary Nodal Status to Guide Surgical Decision-Making in Early-Stage Breast Cancer
Jiao Li, Weimei Ma, Xinhua Jiang, Chunyan Cui, Hongli Wang, Jiewen Chen, Runcong Nie, Yaopan Wu, Li Li
J. Cancer 2019; 10(5): 1263-1274. doi:10.7150/jca.32386
[Abstract] [Full text] [PDF]

Research Paper
Prognosis of EGFR-mutant advanced lung adenocarcinoma patients with different intrathoracic metastatic patterns
Fang Hu, Bo Zhang, Changhui Li, Jianlin Xu, Huimin Wang, Ping Gu, Xiaoxuan Zheng, Wei Nie, Yinchen Shen, Hai Zhang, Ping Hu, Xueyan Zhang
J. Cancer 2019; 10(5): 1254-1262. doi:10.7150/jca.28601
[Abstract] [Full text] [PDF]

Letter
Diagnostic and prognostic value of microRNAs for cancers- strategies and approaches to improve the clinical utility
Rama Jayaraj, Chellan Kumarasamy, Shanthi Sabarimurugan, Siddhartha Baxi
J. Cancer 2019; 10(5): 1252-1253. doi:10.7150/jca.28581
[Abstract] [Full text] [PDF]

Research Paper
Overexpression of FZD1 is Associated with a Good Prognosis and Resistance of Sunitinib in Clear Cell Renal Cell Carcinoma
Qiang Peng, Lu Wang, Danfeng Zhao, Yulin Lv, Hongzhi Wang, Guang Chen, Jiaqi Wang, Wanhai Xu
J. Cancer 2019; 10(5): 1237-1251. doi:10.7150/jca.28662
[Abstract] [Full text] [PDF]

Review
Cryoablation versus Partial Nephrectomy for Clinical Stage T1 Renal Masses: A Systematic Review and Meta-Analysis
Wen Deng, Luyao Chen, Yibing Wang, Xiaoqiang Liu, Gongxian Wang, Weipeng Liu, Cheng Zhang, Xiaochen Zhou, Yu Li, Bin Fu
J. Cancer 2019; 10(5): 1226-1236. doi:10.7150/jca.28881
[Abstract] [Full text] [PDF]

Research Paper
Palliative beam radiotherapy offered real-world survival benefit to metastatic rectal cancer: A large US population-based and propensity score-matched study
Qi Liu, Zezhi Shan, Dakui Luo, Sanjun Cai, Qingguo Li, Xinxiang Li
J. Cancer 2019; 10(5): 1216-1225. doi:10.7150/jca.28768
[Abstract] [Full text] [PDF]

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