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Deregulated Wnt signaling initiates most cases of colorectal cancer (CRC). Butyrate, a product of dietary fiber, hyperactivates Wnt signaling, resulting in induction of CRC cell apoptosis, which may in part explain the protective action of fiber. Nonsense mediated decay (NMD) of mRNAs containing premature stop codons (PTCs) affects tumorigenesis and upregulates Wnt signaling in human embryonic stem cells. . More ...
Yes Associated Protein 1 (YAP) and Transcriptional coactivator with PDZ-Binding Motif (TAZ) have gained notoriety for their ability to drive tumor initiation and progression in a wide variety of cancers, including melanoma. YAP and TAZ act as drivers of melanoma through its interaction with the TEAD family of transcription factors. Verteporfin is a benzoporphyrin derivative that is used clinically for photodynamic treatment of macular degeneration. . More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
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Research Paper
PSME3 Promotes TGFB1 Secretion by Pancreatic Cancer Cells to Induce Pancreatic Stellate Cell Proliferation
Lianyuan Yu, Jun-Jie Li, Xiao-Long Liang, Huanwen Wu, Zhiyong Liang
J. Cancer 2019; 10(9): 2128-2138. doi:10.7150/jca.30235
[Abstract] [Full text] [PDF]

Review
BRCA Genes: The Role in Genome Stability, Cancer Stemness and Therapy Resistance
Ielizaveta Gorodetska, Iryna Kozeretska, Anna Dubrovska
J. Cancer 2019; 10(9): 2109-2127. doi:10.7150/jca.30410
[Abstract] [Full text] [PDF]

Research Paper
Impact of Age on Risk of Lymph Node Positivity in Patients with Colon Cancer
Haolu Wang, Hao Lu, Haotian Yang, Xianwen Zhang, Erik W. Thompson, Michael S. Roberts, Zhiqian Hu, Xiaowen Liang, Xinxing Li
J. Cancer 2019; 10(9): 2102-2108. doi:10.7150/jca.28377
[Abstract] [Full text] [PDF]

Research Paper
High Expression of PQBP1 and Low Expression of PCK2 are Associated with Metastasis and Recurrence of Osteosarcoma and Unfavorable Survival Outcomes of the Patients
Yong Zhang, Haiyue Zhao, Wu Xu, Dinghua Jiang, Lixin Huang, Lisong Li
J. Cancer 2019; 10(9): 2091-2101. doi:10.7150/jca.28480
[Abstract] [Full text] [PDF]

Research Paper
Cisplatin based induction chemotherapy modified by ERCC1 improved the outcome of young adults with locally advanced oral squamous cell carcinoma
Yin Gong, Houyu Ju, Guoxin Ren, Yunteng Wu
J. Cancer 2019; 10(9): 2083-2090. doi:10.7150/jca.28959
[Abstract] [Full text] [PDF]

Review
Interleukin-35 as an Emerging Player in Tumor Microenvironment
Wenhua Xue, Dan Yan, Quancheng Kan
J. Cancer 2019; 10(9): 2074-2082. doi:10.7150/jca.29170
[Abstract] [Full text] [PDF]

Research Paper
Simultaneous Inhibition of EGFR and HER2 via Afatinib Augments the Radiosensitivity of Nasopharyngeal Carcinoma Cells
Fangling Huang, Xujun Liang, Xiaoli Min, Ye Zhang, Guoqiang Wang, Zhengrong Peng, Fang Peng, Maoyu Li, Lin Chen, Yongheng Chen
J. Cancer 2019; 10(9): 2063-2073. doi:10.7150/jca.29327
[Abstract] [Full text] [PDF]

Research Paper
Low Preoperative Lymphocyte to Monocyte Ratio Serves as a Worse Prognostic Marker in Patients with Esophageal Squamous Cell Carcinoma Undergoing Curative Tumor Resection
Qian Song, Jun-zhou Wu, Sheng Wang
J. Cancer 2019; 10(9): 2057-2062. doi:10.7150/jca.29383
[Abstract] [Full text] [PDF]

Research Paper
Preoperative anemia as a prognostic factor in patients with lung cancer: a systematic review and meta-analysis of epidemiological studies
Yang Liu, Yun-Peng Bai, Zi-Fang Zhou, Chang-Rui Jiang, Zhe Xu, Xiao-Xi Fan
J. Cancer 2019; 10(9): 2047-2056. doi:10.7150/jca.29410
[Abstract] [Full text] [PDF]

Review
Unravel the molecular mechanism of XBP1 in regulating the biology of cancer cells
Weimei Shi, Zhixi Chen, Linfu Li, Hai Liu, Rui Zhang, Qilai Cheng, Daohua Xu, Longhuo Wu
J. Cancer 2019; 10(9): 2035-2046. doi:10.7150/jca.29421
[Abstract] [Full text] [PDF]

Research Paper
Long non-coding RNA UASR1 promotes proliferation and migration of breast cancer cells through the AKT/mTOR pathway
Zhe Cao, Ping Wu, Min Su, Hongyan Ling, Ramina Khoshaba, Chenfei Huang, Han Gao, Yan Zhao, Jinjun Chen, Qianjin Liao, Deliang Cao, Junfei Jin, Xuewen Zhang
J. Cancer 2019; 10(9): 2025-2034. doi:10.7150/jca.29457
[Abstract] [Full text] [PDF]

Research Paper
LncRNA HOTAIR up-regulation is strongly related with lymph nodes metastasis and LAR subtype of Triple Negative Breast Cancer
Francesca Collina, Gabriella Aquino, Marianna Brogna, Sabrina Cipolletta, Gaetano Buonfanti, Michelino De Laurentiis, Maurizio Di Bonito, Monica Cantile, Gerardo Botti
J. Cancer 2019; 10(9): 2018-2024. doi:10.7150/jca.29670
[Abstract] [Full text] [PDF]

Research Paper
EZH2/Bcl-2 Coexpression Predicts Worse Survival in Diffuse Large B-cell Lymphomas and Demonstrates Poor Efficacy to Rituximab in Localized Lesions
Yujie Deng, Xiaohui Chen, Chuanzhong Huang, Gang Chen, Fangfang Chen, Jianping Lu, Xi Shi, Cheng He, Zhiyong Zeng, Yanhua Qiu, Junqiang Chen, Rongbo Lin, Yanping Chen, Junmin Chen
J. Cancer 2019; 10(9): 2006-2017. doi:10.7150/jca.29807
[Abstract] [Full text] [PDF]

Research Paper
Cytochalasin H Inhibits Angiogenesis via the Suppression of HIF-1α Protein Accumulation and VEGF Expression through PI3K/AKT/P70S6K and ERK1/2 Signaling Pathways in Non-Small Cell Lung Cancer Cells
Yuefan Ma, Zihan Xiu, Zhiyuan Zhou, Bingyu Huang, Jiao Liu, Xiaofeng Wu, Sanzhong Li, Xudong Tang
J. Cancer 2019; 10(9): 1997-2005. doi:10.7150/jca.29933
[Abstract] [Full text] [PDF]

Research Paper
ERG Tumor Type is Less Frequent in High Grade and High Stage Prostate Cancers of Chinese Men
Jiang Baohong, Jason Sedarsky, Shiv Srivastava, Isabell Sesterhenn, Albert Dobi, Li Quanlin
J. Cancer 2019; 10(9): 1991-1996. doi:10.7150/jca.30025
[Abstract] [Full text] [PDF]

Research Paper
The Efficacy of Upfront Intracranial Radiation with TKI Compared to TKI Alone in the NSCLC Patients Harboring EGFR Mutation and Brain Metastases
Chunyu Wang, Xiaotong Lu, Zongmei Zhou, Jingbo Wang, Zhouguang Hui, Jun Liang, QinFu Feng, Dongfu Chen, Zefen Xiao, Jima Lv, Xiaozhen Wang, Xin Wang, Tao Zhang, Lei Deng, Wenqing Wang, Jianping Xiao, Junling Li, Nan Bi, Luhua Wang
J. Cancer 2019; 10(9): 1985-1990. doi:10.7150/jca.30131
[Abstract] [Full text] [PDF]

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