Editors-in-Chief:
Yan-Gao Man, MD., PhD., Director for Research Laboratory and International Collaboration, Bon Secours Cancer Institute, VA, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
  • new Impact factor is 2.64 according to the 2014 release of Journal Citation Reports.
  • Indexed in SCI Expanded, PubMed and full texts in PubMed Central, Europe PubMed Central, and PMC Canada.
  • High visibility of articles over the Internet.

Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...

Journal of Cancer coverJournal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer. Journal of Cancer is published in cooperation with American Registry of Pathology.

Latest papers:

Research Paper
Topotecan Monotherapy in Heavily Pretreated Patients with Progressive Advanced Stage Neuroendocrine Carcinomas
Ingrid Holst Olsen, Ulrich Knigge, Birgitte Federspiel, Carsten Palnæs Hansen, Anna Skov, Andreas Kjær, Seppo W. Langer
J. Cancer 2014; 5(8): 628-632. doi:10.7150/jca.9409
[Abstract] [Full text] [PDF]

Short Communication
DAXAS and COPD Correlation with Cancer
John Organtzis, Sofia Lampaki, Paul Zarogoulidis, Haidong Huang, Qiang Li, Antonis Papaiwannou, Konstantinos Syrigos, Konstantinos Porpodis, Theodora Tsiouda, Wolfgang Hohenforst-Schmidt, Georgia Trakada, Robert Fred Henry Walter, Dimitra Makrantonaki, Georgia Pitsiou, Ioannis Kioumis, Konstantinos Zarogoulidis
J. Cancer 2014; 5(8): 625-627. doi:10.7150/jca.9730
[Abstract] [Full text] [PDF]

Research Paper
Pyrroloquinoline Quinone Induces Cancer Cell Apoptosis via Mitochondrial-Dependent Pathway and Down-Regulating Cellular Bcl-2 Protein Expression
Zhihui Min, Lingyan Wang, Jianjun Jin, Xiangdong Wang, Bijun Zhu, Hao Chen, Yunfeng Cheng
J. Cancer 2014; 5(7): 609-624. doi:10.7150/jca.9002
[Abstract] [Full text] [PDF]

Research Paper
Newly Identified Cancer-Associated Role of Human Neuronal Growth Regulator 1 (NEGR1)
Hyejin Kim, Ji-Sook Hwang, Bogman Lee, Jinpyo Hong, Soojin Lee
J. Cancer 2014; 5(7): 598-608. doi:10.7150/jca.8052
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Transcatheter Arterial Chemoembolization for Intermediate-Stage Hepatocellular Carcinoma: Clinical Outcome and Safety in Elderly Patients
Hiroki Nishikawa, Ryuichi Kita, Toru Kimura, Yoshiaki Ohara, Haruhiko Takeda, Azusa Sakamoto, Sumio Saito, Norihiro Nishijima, Akihiro Nasu, Hideyuki Komekado, Yukio Osaki
J. Cancer 2014; 5(7): 590-597. doi:10.7150/jca.9413
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
3.0T MR-CAD: Clinical Value in Diagnosis of Breast Tumor Compared with Conventional MRI
Yu-Hui Liu, Liang Xu, Li-Heng Liu, Xiao-Shan Liu, Zhong-Yu Hou, Dong-Liang Hou, Zhao-Qiu Chen, Wen-Wu Li, Yong Huang
J. Cancer 2014; 5(7): 585-589. doi:10.7150/jca.9785
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Characterization of Cancer Stem-Like Cells Derived from Mouse Induced Pluripotent Stem Cells Transformed by Tumor-Derived Extracellular Vesicles
Ting Yan, Akifumi Mizutani, Ling Chen, Mai Takaki, Yuki Hiramoto, Shuichi Matsuda, Tsukasa Shigehiro, Tomonari Kasai, Takayuki Kudoh, Hiroshi Murakami, Junko Masuda, Mary J. C. Hendrix, Luigi Strizzi, David S. Salomon, Li Fu, Masaharu Seno
J. Cancer 2014; 5(7): 572-584. doi:10.7150/jca.8865
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Far Beyond the Usual Biomarkers in Breast Cancer: A Review
Brunna dos Anjos Pultz, Felipe Andrés Cordero da Luz, Paulo Rogério de Faria, Ana Paula Lima Oliveira, Rogério Agenor de Araújo, Marcelo José Barbosa Silva
J. Cancer 2014; 5(7): 559-571. doi:10.7150/jca.8925
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Metastatic Hepatocarcinoma He/De Tumor Model in Rat
Gyorgy Trencsenyi, Terez Marian, Fruzsina Bako, Miklos Emri, Gabor Nagy, Pal Kertai, Gaspar Banfalvi
J. Cancer 2014; 5(7): 548-558. doi:10.7150/jca.9315
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
FGF10: Type III Epithelial Mesenchymal Transition and Invasion in Breast Cancer Cell Lines
Ali Abolhassani, Gholam Hossein Riazi, Ebrahim Azizi, Saeid Amanpour, Samad Muhammadnejad, Mahnaz Haddadi, Ali Zekri, Reza Shirkoohi
J. Cancer 2014; 5(7): 537-547. doi:10.7150/jca.7797
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Quantitative iTRAQ LC-MS/MS Proteomics Reveals Transcription Factor Crosstalk and Regulatory Networks in Hypopharyngeal Squamous Cell Carcinoma
Gangcai Zhu, Gengming Cai, Yong Liu, Haolei Tan, Changyun Yu, Meiling Huang, Ming Wei, She Li, Xiangning Cui, Donghai Huang, Yongquan Tian, Xin Zhang
J. Cancer 2014; 5(7): 525-536. doi:10.7150/jca.9207
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
HGF, sIL-6R and TGF-β1 Play a Significant Role in the Progression of Multiple Myeloma
Artur Jurczyszyn, Jacek Czepiel, Grażyna Biesiada, Joanna Gdula-Argasińska, Dorota Cibor, Danuta Owczarek, William Perucki, Aleksander B. Skotnicki
J. Cancer 2014; 5(7): 518-524. doi:10.7150/jca.9266
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Glutathione Peroxidase 7 Suppresses Bile Salt-Induced Expression of Pro-Inflammatory Cytokines in Barrett's Carcinogenesis
Dun-Fa Peng, Tian-Ling Hu, Mohammed Soutto, Abbes Belkhiri, Wael El-Rifai
J. Cancer 2014; 5(7): 510-517. doi:10.7150/jca.9215
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Sorafenib Therapy for BCLC Stage B/C Hepatocellular Carcinoma; Clinical Outcome and Safety in Aged Patients: A Multicenter Study in Japan
Hiroki Nishikawa, Haruhiko Takeda, Kaoru Tsuchiya, Kouji Joko, Chikara Ogawa, Hiroyoshi Taniguchi, Etsuro Orito, Yasushi Uchida, Yukio Osaki, Namiki Izumi, Japanese Red Cross Liver Study Group
J. Cancer 2014; 5(7): 499-509. doi:10.7150/jca.9257
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Outcome of Breast Cancer Patients Treated outside of Clinical Trials
Nagi S. El Saghir, Hussein A. Assi, Sara M. Jaber, Katia E. Khoury, Zahi Nachef, Hana F. Mikdashi, Nadine S. El-Asmar, Toufic A. Eid
J. Cancer 2014; 5(6): 491-498. doi:10.7150/jca.9216
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Geldanamycin and Its Derivatives Inhibit the Growth of Myeloma Cells and Reduce the Expression of the MET Receptor
Artur Jurczyszyn, Anna Zebzda, Jacek Czepiel, William Perucki, Stanisława Bazan-Socha, Dorota Cibor, Danuta Owczarek, Marcin Majka
J. Cancer 2014; 5(6): 480-490. doi:10.7150/jca.8731
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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