Editors-in-Chief:
Yan-Gao Man, MD., PhD., Co-Director, Laboratory of Proteomics and Protein Sciences, Veterans Affair Health System, Baltimore, MD, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...
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Journal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer.


Research Paper
Long-term Patterns of Regional Failure for Nasopharyngeal Carcinoma following Intensity-Modulated Radiation Therapy
Fen Xue, Chaosu Hu, Xiayun He
J. Cancer 2017; 8(6): 993-999. doi:10.7150/jca.17858
[Abstract] [Full text] [PDF]

Research Paper
Foretinib Enhances the Radiosensitivity in Esophageal Squamous Cell Carcinoma by Inhibiting Phosphorylation of c-Met
Guang-Zong Chen, Wang-Shu Dai, Hong-Cheng Zhu, Hong-Mei Song, Xi Yang, Yuan-Dong Wang, Hua Min, Qian Lu, Shu Liu, Xin-Chen Sun, Xiao-Ning Zeng
J. Cancer 2017; 8(6): 983-992. doi:10.7150/jca.18135
[Abstract] [Full text] [PDF]

Research Paper
Is pretreatment Epstein-Barr virus DNA still associated with 6-year survival outcomes in locoregionally advanced nasopharyngeal carcinoma?
Ya-Nan Jin, Ji-Jin Yao, Fan Zhang, Si-Yang Wang, Wang-Jian Zhang, Guan-Qun Zhou, Zhen-Yu Qi, Ying Sun
J. Cancer 2017; 8(6): 976-982. doi:10.7150/jca.18124
[Abstract] [Full text] [PDF]

Research Paper
The monocyte to red blood cell count ratio is a strong predictor of postoperative survival in colorectal cancer patients: The Fujian prospective investigation of cancer (FIESTA) study
Feng Peng, Dan Hu, Xiandong Lin, Gang Chen, Binying Liang, Chao Li, Yan Chen, Zhaolei Cui, Hejun Zhang, Jixiu Lin, Xiongwei Zheng, Wenquan Niu
J. Cancer 2017; 8(6): 967-975. doi:10.7150/jca.18000
[Abstract] [Full text] [PDF]

Research Paper
Influence of Cervical Node Necrosis of Different Grades on the Prognosis of Nasopharyngeal Carcinoma Patients Treated with Intensity-Modulated Radiotherapy
Lu-Lu Zhang, Jia-Xiang Li, Guan-Qun Zhou, Ling-Long Tang, Jun Ma, Ai-Hua Lin, Zhen-Yu Qi, Ying Sun
J. Cancer 2017; 8(6): 959-966. doi:10.7150/jca.17998
[Abstract] [Full text] [PDF]

Research Paper
Comparison of prognostic nomograms based on different nodal staging systems in patients with resected gastric cancer
Zi-Xian Wang, Miao-Zhen Qiu, Yu-Ming Jiang, Zhi-Wei Zhou, Guo-Xin Li, Rui-Hua Xu
J. Cancer 2017; 8(6): 950-958. doi:10.7150/jca.17370
[Abstract] [Full text] [PDF]

Research Paper
Mutual Regulation of MiR-199a-5p and HIF-1α Modulates the Warburg Effect in Hepatocellular Carcinoma
Binkui Li, Liru He, Dinglan Zuo, Wei He, Yongjin Wang, Yuanping Zhang, Wenwu Liu, Yunfei Yuan
J. Cancer 2017; 8(6): 940-949. doi:10.7150/jca.17496
[Abstract] [Full text] [PDF]

Research Paper
DICER1 regulates endometrial carcinoma invasion via histone acetylation and methylation
Bilan Li, Wen Lu, Junjie Qu, Yongli Zhang, Xiaoping Wan
J. Cancer 2017; 8(6): 933-939. doi:10.7150/jca.17435
[Abstract] [Full text] [PDF]

Research Paper
Risk factors for cervical intraepithelial neoplasia and cervical cancer in Chinese women: large study in Jiexiu, Shanxi Province, China
Zhilian Wang, Jintao Wang, Jinrong Fan, Weihong Zhao, Xin Yang, Lingmei Wu, Dongyan Li, ling Ding, Wei Wang, Junjie Xu, Michelle Stram, Chengquan Zhao, Min Hao
J. Cancer 2017; 8(6): 924-932. doi:10.7150/jca.17416
[Abstract] [Full text] [PDF]

Research Paper
Super Aqueous Solubility of Albendazole in β-Cyclodextrin for Parenteral Application in Cancer therapy
Krishna Pillai, Javed Akhter, David Lawson Morris
J. Cancer 2017; 8(6): 913-923. doi:10.7150/jca.17301
[Abstract] [Full text] [PDF]

Research Paper
Analysis of origin and protein-protein interaction maps suggests distinct oncogenic role of nuclear EGFR during cancer evolution
Ainur Sharip, Diyora Abdukhakimova, Xiao Wang, Alexey Kim, Yevgeniy Kim, Aigul Sharip, Askarbek Orakov, Lixia Miao, Qinglei Sun, Yue Chen, Zhenbang Chen, Yingqiu Xie
J. Cancer 2017; 8(5): 903-912. doi:10.7150/jca.17961
[Abstract] [Full text] [PDF]

Research Paper
Increased TET1 Expression in Inflammatory Microenvironment of Hyperinsulinemia Enhances the Response of Endometrial Cancer to Estrogen by Epigenetic Modulation of GPER
Qiao-Ying Lv, Bing-Ying Xie, Bing-Yi Yang, Cheng-Cheng Ning, Wei-Wei Shan, Chao Gu, Xue-Zhen Luo, Xiao-Jun Chen, Zhen-Bo Zhang, You-Ji Feng
J. Cancer 2017; 8(5): 894-902. doi:10.7150/jca.17064
[Abstract] [Full text] [PDF]

Research Paper
Aided Diagnosis of Hepatocellular Carcinoma Using Serum Fucosylated Haptoglobin Ratios
Shuxin Shang, Wei Li, Xue Qin, Shu Zhang, Yinkun Liu
J. Cancer 2017; 8(5): 887-893. doi:10.7150/jca.17747
[Abstract] [Full text] [PDF]

Research Paper
CT120: A New Potential Target for c-Myc in Head and Neck Cancers
Elif Baltaci, Betül Seyhan, Onur Baykara, Nur Buyru
J. Cancer 2017; 8(5): 880-886. doi:10.7150/jca.18207
[Abstract] [Full text] [PDF]

Research Paper
MiR-93 Promotes Tumorigenesis and Metastasis of Non-Small Cell Lung Cancer Cells by Activating the PI3K/Akt Pathway via Inhibition of LKB1/PTEN/CDKN1A
Chunmei Li, Jianxin Lyu, Qing H. Meng
J. Cancer 2017; 8(5): 870-879. doi:10.7150/jca.17958
[Abstract] [Full text] [PDF]

Research Paper
Magnetic Resonance Imaging-Detected Tumor Residue after Intensity-Modulated Radiation Therapy and its Association with Post-Radiation Plasma Epstein-Barr Virus Deoxyribonucleic Acid in Nasopharyngeal Carcinoma
Jia-Wei Lv, Guan-Qun Zhou, Jia-Xiang Li, Ling-Long Tang, Yan-Ping Mao, Ai-Hua Lin, Jun Ma, Ying Sun
J. Cancer 2017; 8(5): 861-869. doi:10.7150/jca.17957
[Abstract] [Full text] [PDF]

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