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Deregulated Wnt signaling initiates most cases of colorectal cancer (CRC). Butyrate, a product of dietary fiber, hyperactivates Wnt signaling, resulting in induction of CRC cell apoptosis, which may in part explain the protective action of fiber. Nonsense mediated decay (NMD) of mRNAs containing premature stop codons (PTCs) affects tumorigenesis and upregulates Wnt signaling in human embryonic stem cells. . More ...
Yes Associated Protein 1 (YAP) and Transcriptional coactivator with PDZ-Binding Motif (TAZ) have gained notoriety for their ability to drive tumor initiation and progression in a wide variety of cancers, including melanoma. YAP and TAZ act as drivers of melanoma through its interaction with the TEAD family of transcription factors. Verteporfin is a benzoporphyrin derivative that is used clinically for photodynamic treatment of macular degeneration. . More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
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Research Paper
The role of postoperative radiotherapy for completely resected pIIIA-N2 non-small cell lung cancer patients with different clinicopathological features: a systemic review and meta-analysis
Tingting Liu, Yanshu Mu, Jun Dang, Guang Li
J. Cancer 2019; 10(17): 3941-3949. doi:10.7150/jca.28680
[Abstract] [Full text] [PDF]

Research Paper
Surgical Resection plus Radiofrequency Ablation versus Radical Surgery for Hepatocellular Carcinoma: A Propensity Score Matching Analysis
Cheng Zhou, Xiangyu Zhang, Yuanfei Peng, Kaiqian Zhou, Jie Hu, Lei Yu, Feiyu Chen, Shuangjian Qiu, Jian Zhou, Jia Fan, Lan Zhang, Zheng Wang
J. Cancer 2019; 10(17): 3933-3940. doi:10.7150/jca.29501
[Abstract] [Full text] [PDF]

Research Paper
GPC6 Promotes Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma
Chunmei Fan, Chaofeng Tu, Peng Qi, Can Guo, Bo Xiang, Ming Zhou, Xiayu Li, Xu Wu, Xiaoling Li, Guiyuan Li, Wei Xiong, Zhaoyang Zeng
J. Cancer 2019; 10(17): 3926-3932. doi:10.7150/jca.31345
[Abstract] [Full text] [PDF]

Research Paper
KPNA3 Confers Sorafenib Resistance to Advanced Hepatocellular Carcinoma via TWIST Regulated Epithelial-Mesenchymal Transition
Bo Hu, Jian-Wen Cheng, Jin-Wu Hu, Hong Li, Xiao-Lu Ma, Wei-Guo Tang, Yun-Fan Sun, Wei Guo, Ao Huang, Kai-Qian Zhou, Ping-Ting Gao, Ya Cao, Shuang-Jian Qiu, Jian Zhou, Jia Fan, Xin-Rong Yang
J. Cancer 2019; 10(17): 3914-3925. doi:10.7150/jca.31448
[Abstract] [Full text] [PDF]

Research Paper
circGFRA1 Promotes Ovarian Cancer Progression By Sponging miR-449a
Jie Liu, Furong Yu, Shufen Wang, Xia Zhao, Feng Jiang, Jing Xie, Min Deng
J. Cancer 2019; 10(17): 3908-3913. doi:10.7150/jca.31615
[Abstract] [Full text] [PDF]

Research Paper
Long-Term Survival and Prognostic Factors in Locoregionally Advanced Nasopharyngeal Carcinoma Patients Treated with TPF Induction Chemotherapy followed by Cisplatin-Combined Concurrent Chemoradiotherapy
Qun Zhang, Yan Wang, Jun-Fang Liao, Yu-Feng Ren, Guo-Ping Shen, Shao-Qing Niu, Wei Luo
J. Cancer 2019; 10(17): 3899-3907. doi:10.7150/jca.31663
[Abstract] [Full text] [PDF]

Research Paper
CircABCC2 Regulates Hepatocellular Cancer Progression by Decoying MiR-665
Ning Bai, Eming Peng, Fada Xia, Dong Wang, Xiaogang Li, Xinying Li
J. Cancer 2019; 10(17): 3893-3898. doi:10.7150/jca.31362
[Abstract] [Full text] [PDF]

Research Paper
Novel preoperative nutritional assessment tool and prognostic model for ESCC patients
Jinming Xu, Jinlin Cao, Ying Wang, Xin Yao, Yiqing Wang, Zhehao He, Wang Lv, Jian Hu
J. Cancer 2019; 10(17): 3883-3892. doi:10.7150/jca.31286
[Abstract] [Full text] [PDF]

Research Paper
SIRT5 Promotes Hepatocellular Carcinoma Progression by Regulating Mitochondrial Apoptosis
Rixin Zhang, Chengye Wang, Yu Tian, Yifan Yao, Jiakai Mao, Haibo Wang, Zhenghan Li, Yakun Xu, Mingliang Ye, Liming Wang
J. Cancer 2019; 10(16): 3871-3882. doi:10.7150/jca.31266
[Abstract] [Full text] [PDF]

Research Paper
Upregulation of nucleoprotein AHNAK is associated with poor outcome of pancreatic ductal adenocarcinoma prognosis via mediating epithelial-mesenchymal transition
Zhiwen Zhang, Xiaoding Liu, Rui Huang, Xuguang Liu, Zhiyong Liang, Tonghua Liu
J. Cancer 2019; 10(16): 3860-3870. doi:10.7150/jca.31291
[Abstract] [Full text] [PDF]

Research Paper
Unilateral Axilla-Bilateral Areola Approach for Thyroidectomy by da Vinci Robot: 500 Cases Treated by the Same Surgeon
Pengfei Liu, Ye Zhang, Xiaowei Qi, Haoxi Liu, Junze Du, Jing Liu, Junlan Liu, Wenying Fu, Yi Zhang, Jun Jiang, Linjun Fan
J. Cancer 2019; 10(16): 3851-3859. doi:10.7150/jca.31463
[Abstract] [Full text] [PDF]

Research Paper
RAG1 high expression associated with IKZF1 dysfunction in adult B-cell acute lymphoblastic leukemia
Qi Han, Jinlong Ma, Yan Gu, Huihui Song, Malika Kapadia, Yuka Imamura Kawasawa, Sinisa Dovat, Chunhua Song, Zheng Ge
J. Cancer 2019; 10(16): 3842-3850. doi:10.7150/jca.33989
[Abstract] [Full text] [PDF]

Research Paper
Mast cells induce epithelial-to-mesenchymal transition and migration in non-small cell lung cancer through IL-8/Wnt/β-catenin pathway
Jingjing Qu, Tianli Cheng, Li Liu, Jianfu Heng, Xiaobao Liu, Ziyi Sun, Wenxiang Wang, Kunyan Li, Nong Yang
J. Cancer 2019; 10(16): 3830-3841. doi:10.7150/jca.29953
[Abstract] [Full text] [PDF]

Research Paper
PGC1α downregulation and glycolytic phenotype in thyroid cancer
Chien-Liang Liu, Po-Sheng Yang, Tao-Yeuan Wang, Shih-Yuan Huang, Yi-Hue Kuo, Shih-Ping Cheng
J. Cancer 2019; 10(16): 3819-3829. doi:10.7150/jca.30018
[Abstract] [Full text] [PDF]

Research Paper
High pretreatment serum CA19-9 level predicts a poor prognosis for patients with stage III colon cancer after curative resection and adjuvant chemotherapy
Wenhao Zhou, Fan Yang, Jianhong Peng, Fulong Wang, Yuzhu Lin, Wu Jiang, Xia Yang, Liren Li, Zhenhai Lu, Desen Wan, Zhizhong Pan, Wenhua Fan
J. Cancer 2019; 10(16): 3810-3818. doi:10.7150/jca.31375
[Abstract] [Full text] [PDF]

Review
The Epithelial-Myeloid-Transition (EMyeT) of cancer cells as a wrongly perceived primary inflammatory process eventually progressing to a bone remodeling malignancy: the alternative pathway for Epithelial- Mesenchymal-Transition hypothesis (EMT)?
Henning M. Schramm
J. Cancer 2019; 10(16): 3798-3809. doi:10.7150/jca.31364
[Abstract] [Full text] [PDF]

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