Editors-in-Chief:
Yan-Gao Man, MD., PhD., Director for Research Laboratory and International Collaboration, Bon Secours Cancer Institute, VA, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...
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Journal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer.

Latest papers:

Research Paper
Transduction of Recombinant M3-p53-R12 Protein Enhances Human Leukemia Cell Apoptosis
Tsung Chi Lu, Guan- Hao Zhao, Yao Yun Chen, Chia-Ying Chien, Chi-Hung Huang, Kwang Hui Lin, Shen Liang Chen
J. Cancer 2016; 7(10): 1360-1373. doi:10.7150/jca.15155
[Abstract] [Full text] [PDF]

Research Paper
Should All Nasopharyngeal Carcinoma with Paranasal Sinus Invasion Be Staged as T3 in the Intensity-Modulated Radiotherapy Era? A Study of 1811 Cases
Yuan Zhang, Hao Peng, Rui Guo, Wen-Fei Li, Lei Chen, Xu Liu, Ling-Long Tang, Li-Zhi Liu, Li Li, Qing Liu, Ying Sun, Jun Ma
J. Cancer 2016; 7(10): 1353-1359. doi:10.7150/jca.15141
[Abstract] [Full text] [PDF]

Research Paper
Tailored Selection of First-Line Cisplatin-Based Chemotherapy in Patients with Metastatic Urothelial Carcinoma of Bladder
Meng-Che Hsieh, Cheng-Hua Huang, Po-Hui Chiang, Yen-Yang Chen, Yeh Tang, Yu-Li Su
J. Cancer 2016; 7(10): 1347-1352. doi:10.7150/jca.15213
[Abstract] [Full text] [PDF]

Research Paper
Serum Adiponectin Level May be an Independent Predictor of Clear Cell Renal Cell Carcinoma
Hongkai Wang, Junlong Wu, Weijie Gu, Beihe Wang, Fangning Wan, Bo Dai, Hailiang Zhang, Guohai Shi, Yijun Shen, Yiping Zhu, Yao Zhu, Dingwei Ye
J. Cancer 2016; 7(10): 1340-1346. doi:10.7150/jca.14716
[Abstract] [Full text] [PDF]

Review
Pancreatic Cancer from Molecular Pathways to Treatment Opinion
Michail Karanikas, Agis Esempidis, Zeinep Tzoutze Memet Chasan, Theodora Deftereou, Maria Antonopoulou, Ferdi Bozali, Kyriakos Amarantidis, Yan-Gao Man
J. Cancer 2016; 7(10): 1328-1339. doi:10.7150/jca.15419
[Abstract] [Full text] [PDF]

Research Paper
Multi-target siRNA: Therapeutic Strategy for Hepatocellular Carcinoma
Tiejun Li, Yuwen Xue, Guilan Wang, Tingting Gu, Yunlong Li, York Yuanyuan Zhu, Li Chen
J. Cancer 2016; 7(10): 1317-1327. doi:10.7150/jca.15157
[Abstract] [Full text] [PDF]

Perspective
Clinical Efficacy of Ovarian Cancer Screening
Masafumi Koshiyama, Noriomi Matsumura, Ikuo Konishi
J. Cancer 2016; 7(10): 1311-1316. doi:10.7150/jca.14615
[Abstract] [Full text] [PDF]

Research Paper
Increased Expression of Several Collagen Genes is Associated with Drug Resistance in Ovarian Cancer Cell Lines
Radosław Januchowski, Monika Świerczewska, Karolina Sterzyńska, Karolina Wojtowicz, Michał Nowicki, Maciej Zabel
J. Cancer 2016; 7(10): 1295-1310. doi:10.7150/jca.15371
[Abstract] [Full text] [PDF]

Review
Cancer Hallmarks, Biomarkers and Breast Cancer Molecular Subtypes
Xiaofeng Dai, Liangjian Xiang, Ting Li, Zhonghu Bai
J. Cancer 2016; 7(10): 1281-1294. doi:10.7150/jca.13141
[Abstract] [Full text] [PDF]

Research Paper
Association between the OGG1 Ser326Cys Polymorphism and Cancer Risk: Evidence from 152 Case-Control Studies
Hua Zou, Qing Li, Wei Xia, Yong Liu, Xi Wei, Dong Wang
J. Cancer 2016; 7(10): 1273-1280. doi:10.7150/jca.15035
[Abstract] [Full text] [PDF]

Research Paper
Use of Plasma Metabolomics to Identify Diagnostic Biomarkers for Early Stage Epithelial Ovarian Cancer
Lijun Fan, Mingzhu Yin, Chaofu Ke, Tingting Ge, Guangming Zhang, Wang Zhang, Xiaohua Zhou, Ge Lou, Kang Li
J. Cancer 2016; 7(10): 1265-1272. doi:10.7150/jca.15074
[Abstract] [Full text] [PDF]

Review
LncRNAs and Esophageal Squamous Cell Carcinoma - Implications for Pathogenesis and Drug Development
Wen-Jun Shen, Fan Zhang, Xing Zhao, Jianzhen Xu
J. Cancer 2016; 7(10): 1258-1264. doi:10.7150/jca.14869
[Abstract] [Full text] [PDF]

Research Paper
Curcumin Sensitizes Silymarin to Exert Synergistic Anticancer Activity in Colon Cancer Cells
Amanda Montgomery, Temitope Adeyeni, KayKay San, Rita M. Heuertz, Uthayashanker R. Ezekiel
J. Cancer 2016; 7(10): 1250-1257. doi:10.7150/jca.15690
[Abstract] [Full text] [PDF]

Research Paper
Comparison of Uncinate Process Cancer and Non-Uncinate Process Pancreatic Head Cancer
Chang Liu, Xiaodong Tian, Xuehai Xie, Hongqiao Gao, Yan Zhuang, Yinmo Yang
J. Cancer 2016; 7(10): 1242-1249. doi:10.7150/jca.15062
[Abstract] [Full text] [PDF]

Review
The Role of Mir-148a in Cancer
Yue Li, Xiyun Deng, Xiaomin Zeng, Xiaoning Peng
J. Cancer 2016; 7(10): 1233-1241. doi:10.7150/jca.14616
[Abstract] [Full text] [PDF]

Research Paper
Reduced Expression of FADS1 Predicts Worse Prognosis in Non-Small-Cell Lung Cancer
Dong Wang, Yan Lin, Bei Gao, Shumei Yan, Huini Wu, Yong Li, Qiuliang Wu, Yucheng Wei
J. Cancer 2016; 7(10): 1226-1232. doi:10.7150/jca.15403
[Abstract] [Full text] [PDF]

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