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Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
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Research Paper
Distribution and Clinical Utility of the 21-gene Recurrence Score in Pure Mucinous Breast Cancer Patients: a case-control study
Wei Wang, Xiaosong Chen, Lin Lin, Xiaochun Fei, David H. Garfield, Jin Hong, Weiqi Gao, Siji Zhu, Jiayi Wu, Ou Huang, Jianrong He, Yafen Li, Li Zhu, Weiguo Chen, Kunwei Shen
J. Cancer 2018; 9(18): 3216-3224. doi:10.7150/jca.27291
[Abstract] [Full text] [PDF]

Research Paper
Validation of Urine-based Gene Classifiers for Detecting Bladder Cancer in a Chinese Study
Chengtao Han, Lourdes Mengual, Bin Kang, Juan José Lozano, Xiaoqun Yang, Cuizhu Zhang, Antonio Alcaraz, Ji Liang, Dingwei Ye
J. Cancer 2018; 9(17): 3208-3215. doi:10.7150/jca.24506
[Abstract] [Full text] [PDF]

Research Paper
Inhibition of Transient Receptor Potential Vanilloid 6 channel, elevated in human ovarian cancers, reduces tumour growth in a xenograft model
Hui Xue, Yuzhuo Wang, Tyson J. MacCormack, Tyler Lutes, Christopher Rice, Michelle Davey, Dominique Dugourd, T. Toney Ilenchuk, John M. Stewart
J. Cancer 2018; 9(17): 3196-3207. doi:10.7150/jca.20639
[Abstract] [Full text] [PDF]

Research Paper
Study to evaluate the immunomodulatory effects of radiofrequency ablation compared to surgical resection for liver cancer
Ketevan Mazmishvili, Kumar Jayant, Nona Janikashvili, Nino Kikodze, Malkhaz Mizandari, Ia Pantsulaia, Natela Paksashvili, Mikael H Sodergren, Isabella Reccia, Madhava Pai, Nagy Habib, Tinatin Chikovani
J. Cancer 2018; 9(17): 3187-3195. doi:10.7150/jca.25084
[Abstract] [Full text] [PDF]

Research Paper
Alternative Splicing of SMAD4 and Its Function in HaCaT Cells in Response to UVB Irradiation
Irfan Ullah, Yi Liao, Rongxue Wan, Liling Tang, Jianguo Feng
J. Cancer 2018; 9(17): 3177-3186. doi:10.7150/jca.24756
[Abstract] [Full text] [PDF]

Research Paper
Significantly higher pathologic complete response (pCR) after the concurrent use of trastuzumab and anthracycline-based neoadjuvant chemotherapy for HER2-positive breast cancer: Evidence from a meta-analysis of randomized controlled trials
Yu-tuan Wu, Zhou Xu, Bilal Arshad, Jiu-song Wu, Ke Zhang, He Wu, Xin Li, Hao Li, Ying-cun Li, Zhong-liang Wang, Kai-nan Wu, Ling-quan Kong
J. Cancer 2018; 9(17): 3168-3176. doi:10.7150/jca.24701
[Abstract] [Full text] [PDF]

Research Paper
Overall survival and cancer-specific survival in patients with surgically resected pancreatic head adenocarcinoma: A competing risk nomogram analysis
Chaobin He, Yu Zhang, Zhiyuan Cai, Xiaojun Lin, Shengping Li
J. Cancer 2018; 9(17): 3156-3167. doi:10.7150/jca.25494
[Abstract] [Full text] [PDF]

Research Paper
Covalent CDK7 Inhibitor THZ1 Inhibits Myogenic Differentiation
Xinqi Ma, Xielan Kuang, Qing Xia, Zixin Huang, Yuting Fan, Jie Ning, Jiajie Wen, Han Zhang, Jianhua Yan, Qingjiong Zhang, Huangxuan Shen, Chongde Long
J. Cancer 2018; 9(17): 3149-3155. doi:10.7150/jca.25395
[Abstract] [Full text] [PDF]

Research Paper
Role of CXCR7 as a Common Predictor for Prognosis in Solid Tumors: a Meta-Analysis
Qitai Zhao, Penghua Zhang, Guohui Qin, Feifei Ren, Yujia Zheng, Yamin Qiao, Ting Sun, Yi Zhang
J. Cancer 2018; 9(17): 3138-3148. doi:10.7150/jca.25377
[Abstract] [Full text] [PDF]

Review
Mesenchymal Stem Cell Derived Exosomes in Cancer Progression, Metastasis and Drug Delivery: A Comprehensive Review
Jingyi Zhou, Xiaohong Tan, Yiheng Tan, Qiuyu Li, Jianjun Ma, Gangyang Wang
J. Cancer 2018; 9(17): 3129-3137. doi:10.7150/jca.25376
[Abstract] [Full text] [PDF]

Research Paper
Preoperative CEA levels are supplementary to CA19-9 levels in predicting prognosis in patients with resectable intrahepatic cholangiocarcinoma
Chaobin He, Yu Zhang, Yunda Song, Jun Wang, Kaili Xing, Xiaojun Lin, Shengping Li
J. Cancer 2018; 9(17): 3117-3128. doi:10.7150/jca.25339
[Abstract] [Full text] [PDF]

Research Paper
The relationship between miR-302b and EphA2 and their clinical significance in gastric cancer
Lanhua Tang, Huabin Hu, Yijing He, Howard L. Mcleod, Desheng Xiao, Pan Chen, Liangfang Shen, Shan Zeng, Xianli Yin, Jie Ge, Li Li, Jian Ma, Zihua Chen, Jin Huang
J. Cancer 2018; 9(17): 3109-3116. doi:10.7150/jca.25235
[Abstract] [Full text] [PDF]

Research Paper
Clinical Value of Combining 18F-FDG PET/CT and Routine Serum Tumor Markers in The Early Detection of Recurrence Among Follow-up Patients Treated for Cervical Squamous Cell Carcinoma
Rajiv Rai Sookha, Wenhua Zhi, Yanxia Shen, Cordelle Lazare, Ling Wang, Yifan Meng, Canhui Cao, Junbo Hu, Peng Wu
J. Cancer 2018; 9(17): 3101-3108. doi:10.7150/jca.27206
[Abstract] [Full text] [PDF]

Research Paper
Systemic neutrophil lymphocyte ratio and mismatch repair status in colorectal cancer patients: correlation and prognostic value
Wen-Zhuo He, Wan-Ming Hu, Peng-Fei Kong, Lin Yang, Yuan-Zhong Yang, Qian-Kun Xie, Chang Jiang, Chen-Xi Yin, Hui-Juan Qiu, Bei Zhang, Hui-Zhong Zhang, Liang-Ping Xia
J. Cancer 2018; 9(17): 3093-3100. doi:10.7150/jca.26669
[Abstract] [Full text] [PDF]

Review
Exosome-related tumor microenvironment
Cheng Hu, Meijuan Chen, Rilei Jiang, Yuanyuan Guo, Mianhua Wu, Xu Zhang
J. Cancer 2018; 9(17): 3084-3092. doi:10.7150/jca.26422
[Abstract] [Full text] [PDF]

Research Paper
Genetic polymorphisms may influence the vertical growth rate of melanoma
Mariusz Sikora, Lidia Rudnicka, Barbara Borkowska, Agnieszka Kardynał, Monika Słowińska, Adriana Rakowska, Olga Warszawik-Hendzel, Anna Wiergowska, Iwona Ługowska, Piotr Rutkowski, Tadeusz Dębniak, Jan Lubiński, Małgorzata Olszewska
J. Cancer 2018; 9(17): 3078-3083. doi:10.7150/jca.26404
[Abstract] [Full text] [PDF]

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