Editors-in-Chief:
Yan-Gao Man, MD., PhD., Director for Research Laboratory and International Collaboration, Bon Secours Cancer Institute, VA, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
  • new Impact factor is 2.639 according to the 2014 release of Journal Citation Reports.
  • Indexed in SCI Expanded, PubMed and full texts in PubMed Central, Europe PubMed Central, and PMC Canada.
  • High visibility of articles over the Internet.

Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...

Journal of Cancer coverJournal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer. Journal of Cancer is published in cooperation with American Registry of Pathology.

Latest papers:

Research Paper
Colon Cancer Associated Transcript-1 (CCAT1) Expression in Adenocarcinoma of the Stomach
Ido Mizrahi, Haggi Mazeh, Ronit Grinbaum, Nahum Beglaibter, Michael Wilschanski, Vera Pavlov, Muchamad Adileh, Alexander Stojadinovic, Itzhak Avital, Ali Osmay Gure, David Halle, Aviram Nissan
J. Cancer 2015; 6(2): 105-110. doi:10.7150/jca.10568
[Abstract] [Full text] [PDF]

Research Paper
Fibronectin Matrix Formation is a Prerequisite for Colonization of Kidney Tumor Cells in Fibrin
Lynn M. Knowles, Lisa A. Gurski, Jodi K. Maranchie, Jan Pilch
J. Cancer 2015; 6(2): 98-104. doi:10.7150/jca.10496
[Abstract] [Full text] [PDF]

Research Paper
Discovery of Invasion Routes for Nasopharyngeal Adenoid Cystic Carcinoma
Jun Dong, Liang Zhang, Yunxian Mo, Li Tian, Lizhi Liu, Peihong Wu
J. Cancer 2015; 6(1): 90-97. doi:10.7150/jca.10739
[Abstract] [Full text] [PDF]

Research Paper
Changes in Bone Density after Cancer Treatment in Patients with Cervical and Endometrial Cancer
Young Lim Oh, Man Soo Yoon, Dong Soo Suh, Ari Kim, Min Joung Kim, Ji Young Lee, Yong Jung Song, Yong Il Ji, Ki Hyung Kim, Sungwook Chun
J. Cancer 2015; 6(1): 82-89. doi:10.7150/jca.10679
[Abstract] [Full text] [PDF]

Research Paper
ERCC1 Induction after Oxaliplatin Exposure May Depend on KRAS Mutational Status in Colorectal Cancer Cell Line: In Vitro Veritas
A. Orlandi, M. Di Salvatore, C. Bagalà, M. Basso, A. Strippoli, F. Plastino, M.A. Calegari, A. Cassano, A. Astone, C. Barone
J. Cancer 2015; 6(1): 70-81. doi:10.7150/jca.10478
[Abstract] [Full text] [PDF]

Short Research Communication
Spatial and Temporal Fracture Pattern in Breast and Gynecologic Cancer Survivors
Susanta K Hui, Luke Arentsen, Anjali Wilcox, Ryan Shanley, Douglas Yee, Rahel Ghebre
J. Cancer 2015; 6(1): 66-69. doi:10.7150/jca.10288
[Abstract] [Full text] [PDF]

Review
Pathway and Network Approaches for Identification of Cancer Signature Markers from Omics Data
Jinlian Wang, Yiming Zuo, Yan-gao Man, Itzhak Avital, Alexander Stojadinovic, Meng Liu, Xiaowei Yang, Rency S. Varghese, Mahlet G Tadesse, Habtom W Ressom
J. Cancer 2015; 6(1): 54-65. doi:10.7150/jca.10631
[Abstract] [Full text] [PDF]

Research Paper
Upregulation of Acetylcholinesterase Mediated by p53 Contributes to Cisplatin-Induced Apoptosis in Human Breast Cancer Cell
Xiaolei Ye, Changsong Zhang, Yichen Chen, Tianbao Zhou
J. Cancer 2015; 6(1): 48-53. doi:10.7150/jca.10521
[Abstract] [Full text] [PDF]

Research Paper
Differentiation between Malignant and Benign Solitary Lesions in the Liver with 18FDG PET/CT: Accuracy of Age-related Diagnostic Standard
Qian Xia, Yuanbo Feng, Cheng Wu, Gang Huang, Jianjun Liu, Tao Chen, Xiaoguang Sun, Shaoli Song, Linjun Tong, Yicheng Ni
J. Cancer 2015; 6(1): 40-47. doi:10.7150/jca.10422
[Abstract] [Full text] [PDF]

Review
Cancer: We Should Not Forget The Past
Anna Di Lonardo, Sergio Nasi, Simonetta Pulciani
J. Cancer 2015; 6(1): 29-39. doi:10.7150/jca.10336
[Abstract] [Full text] [PDF]

Research Paper
Upregulation of miRNA3195 and miRNA374b Mediates the Anti-Angiogenic Properties of Melatonin in Hypoxic PC-3 Prostate Cancer Cells
Eun Jung Sohn, Gunho Won, Jihyun Lee, Sangyoon Lee, Sung-hoon Kim
J. Cancer 2015; 6(1): 19-28. doi:10.7150/jca.9591
[Abstract] [Full text] [PDF]

Review
Use of Proteins as Biomarkers and Their Role in Carcinogenesis
Paul Zarogoulidis, Kosmas Tsakiridis, Chrisanthi Karapantzou, Sofia Lampaki, Ioannis Kioumis, Georgia Pitsiou, Antonis Papaiwannou, Wolfgang Hohenforst-Schmidt, Haidong Huang, George Kesisis, Ilias Karapantzos, Serafeim Chlapoutakis, Ippokratis Korantzis, Andreas Mpakas, Vasilis Karavasilis, Ioannis Mpoukovinas, Qiang Li, Konstantinos Zarogoulidis
J. Cancer 2015; 6(1): 9-18. doi:10.7150/jca.10560
[Abstract] [Full text] [PDF]

Research Paper
Chemopreventive Effects of Korean Red Ginseng Extract on Rat Hepatocarcinogenesis
Hyemee Kim, Mi-Kyung Hong, Haymie Choi, Hyun-Seuk Moon, Hae-Jeung Lee
J. Cancer 2015; 6(1): 1-8. doi:10.7150/jca.10353
[Abstract] [Full text] [PDF]

Research Paper
MicroRNA-21 Down-regulates Rb1 Expression by Targeting PDCD4 in Retinoblastoma
Fengmei Shen, Meng-Hsuan Mo, Liang Chen, Shejuan An, Xiaohui Tan, Yebo Fu, Katayoon Rezaei, Zuoren Wang, Lin Zhang, Sidney W. Fu
J. Cancer 2014; 5(9): 804-812. doi:10.7150/jca.10456
[Abstract] [Full text] [PDF]

Research Paper
Clinicopathological Analysis on Small Cell Carcinoma of the Prostate in Chinese Patients
Aitao Guo, Shuang Wen, Yaqi Ma, Lixin Wei, Aijun Liu
J. Cancer 2014; 5(9): 797-803. doi:10.7150/jca.9388
[Abstract] [Full text] [PDF]

Research Paper
Amplification of Chromosome 1q Genes Encoding the Phosphoinositide Signalling Enzymes PI4KB, AKT3, PIP5K1A and PI3KC2B in Breast Cancer
Mark G. Waugh
J. Cancer 2014; 5(9): 790-796. doi:10.7150/jca.9794
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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