Editors-in-Chief:
Yan-Gao Man, MD., PhD., Co-Director, Laboratory of Proteomics and Protein Sciences, Veterans Affair Health System, Baltimore, MD, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
new Oncomedicine now accepts submissions.
  • new Impact factor is 3.609 according to the 2016 release of Journal Citation Reports. Congratulations!
  • Indexed in SCI Expanded, PubMed and full texts in PubMed Central, Europe PubMed Central, and PMC Canada.
  • High visibility of articles over the Internet.

Cover suggestion ...details

Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...
Cover image

Journal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer.

Latest papers:

Research Paper
High Expression of 17β-hydroxysteroid Dehydrogenase Type 2 is Associated with a Better Prognosis in Urothelial Carcinoma of the Urinary Tract
Chieh-Tien Wang, Chien-Feng Li, Wen-Jeng Wu, Chun-Nung Huang, Ching-Chia Li, Wei-Ming Li, Ti-Chun Chan, Peir-In Liang, Chung-Hsi Hsing, Kuang-Ming Liao
J. Cancer 2016; 7(15): 2221-2230. doi:10.7150/jca.16777
[Abstract] [Full text] [PDF]

Review
Multidimensional Roles of Collagen Triple Helix Repeat Containing 1 (CTHRC1) in Malignant Cancers
Neng Jiang, YongMei Cui, JunXiu Liu, XiaoLin Zhu, Hui Wu, Zheng Yang, ZunFu Ke
J. Cancer 2016; 7(15): 2213-2220. doi:10.7150/jca.16539
[Abstract] [Full text] [PDF]

Research Paper
Clinicopathological features and relation between anaplastic lymphoma kinase (ALK) mutation and histological subtype of lung adenocarcinoma in Eastern European Caucasian population
Bojan Zaric, Vladimir Stojsic, Milana Panjkovic, Dragana Tegeltija, Vanesa Stepanov, Tomi Kovacevic, Tatjana Sarcev, Davorin Radosavljevic, Aleksandar Milovancev, Vasilis Adamidis, Paul Zarogoulidis, Wolfgang Hohenforst-Schmidt, Georgia Trakada, Aggeliki Rapti, Branislav Perin
J. Cancer 2016; 7(15): 2207-2212. doi:10.7150/jca.16768
[Abstract] [Full text] [PDF]

Research Paper
Alteration status and prognostic value of MET in head and neck squamous cell carcinoma
Yoon Ah Cho, Eun Kyung Kim, Su Jin Heo, Byoung Chul Cho, Hye Ryun Kim, Ji Myung Chung, Sun Och Yoon
J. Cancer 2016; 7(15): 2197-2206. doi:10.7150/jca.16686
[Abstract] [Full text] [PDF]

Research Paper
Downregulation of RNF128 Predicts Progression and Poor Prognosis in Patients with Urothelial Carcinoma of the Upper Tract and Urinary Bladder
Yi-Ying Lee, Chieh-Tien Wang, Steven Kuan-Hua Huang, Wen-Jeng Wu, Chun-Nung Huang, Ching-Chia Li, Ti-Chun Chan, Peir-In Liang, Chung-Hsi Hsing, Chien-Feng Li
J. Cancer 2016; 7(15): 2187-2196. doi:10.7150/jca.16798
[Abstract] [Full text] [PDF]

Research Paper
Association of common variants in MTAP with susceptibility and overall survival of osteosarcoma: a two-stage population-based study in Han Chinese
Liqiang Zhi, Dan Liu, Stephen G. Wu, Tianqing Li, Guanghui Zhao, Bo Zhao, Meng Li
J. Cancer 2016; 7(15): 2179-2186. doi:10.7150/jca.16609
[Abstract] [Full text] [PDF]

Research Paper
To Excavate Biomarkers Predictive of the Response for Capecitabine plus RAD001 through Nanostring-Based Multigene Assay in Advanced Gastric Cancer Patients
Hansang Lee, Jeeyun Lee, Insuk Sohn, Se Hoon Park, Joon Oh Park, Young Suk Park, Kyoung-Mee Kim, Won Ki Kang, Seung Tae Kim
J. Cancer 2016; 7(15): 2173-2178. doi:10.7150/jca.16551
[Abstract] [Full text] [PDF]

Research Paper
Massive parallel sequencing and digital gene expression analysis reveals potential mechanisms to overcome therapy resistance in pulmonary neuroendocrine tumors
Robert Fred Henry Walter, Claudia Vollbrecht, Daniel Christoph, Robert Werner, Jan Schmeller, Elena Flom, Georgia Trakada, Aggeliki Rapti, Vasilis Adamidis, Wolfgang Hohenforst-Schmidt, Jens Kollmeier, Thomas Mairinger, Jeremias Wohlschlaeger, Paul Zarogoulidis, Konstantinos Porpodis, Kurt Werner Schmidt, Fabian Dominik Mairinger
J. Cancer 2016; 7(15): 2165-2172. doi:10.7150/jca.16925
[Abstract] [Full text] [PDF]

Research Paper
The Impact of Clinical Stage on Radiation Doses to Organs at Risk Following Intensity-modulated Radiotherapy in Nasopharyngeal Carcinoma: A Prospective Analysis
Lin Xu, Ji-Jin Yao, Guan-Qun Zhou, Wang-Jian Zhang, Guo-Long Liu, Li-Zhi Liu, Jun Ma, Ying Sun
J. Cancer 2016; 7(14): 2157-2164. doi:10.7150/jca.16476
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
A Novel Prognostic Score, Based on Preoperative Nutritional Status, Predicts Outcomes of Patients after Curative Resection for Gastric Cancer
Xuechao Liu, Haibo Qiu, Jianjun Liu, Shangxiang Chen, Dazhi Xu, Wei Li, Youqing Zhan, Yuanfang Li, Yingbo Chen, Zhiwei Zhou, Xiaowei Sun
J. Cancer 2016; 7(14): 2148-2156. doi:10.7150/jca.16455
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Chemomodulatory Potential of Bartogenic Acid Against DMBA/Croton Oil Induced Two-Step Skin Carcinogenesis in Mice
Chandragouda R. Patil, Bhavin M. Sonara, Umesh B. Mahajan, Kalpesh R. Patil, Dipak D. Patil, Ramchandra B. Jadhav, Sameer N. Goyal, Shreesh Ojha
J. Cancer 2016; 7(14): 2139-2147. doi:10.7150/jca.16446
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Short Research Communication
Transcriptional cofactor Mask2 is required for YAP-induced cell growth and migration in bladder cancer cell
Liang Dong, Fan Lin, Wanjun Wu, Weiren Huang, Zhiming Cai
J. Cancer 2016; 7(14): 2132-2138. doi:10.7150/jca.16438
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Co-expression of Achaete-Scute Homologue-1 and Calcitonin Gene-Related Peptide during NNK-Induced Pulmonary Neuroendocrine Hyperplasia and Carcinogenesis in Hamsters
Xu Naizhen, R. Ilona Linnoila, Shioko Kimura
J. Cancer 2016; 7(14): 2124-2131. doi:10.7150/jca.16399
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Lymphangiogenesis in Classical Hodgkin Lymphoma - Preliminary Study with Clinicopathological Correlations
Daniel Benharroch, Isebrand Prinsloo, Jacob Gopas, Irena Lazarev
J. Cancer 2016; 7(14): 2117-2123. doi:10.7150/jca.16389
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Incidence and predictors of Bone Metastases (BM) and Skeletal-Related Events (SREs) in Small Cell Lung Cancer (SCLC): A Swiss patient cohort
Katrin Conen, Raphael Hagmann, Viviane Hess, Alfred Zippelius, Sacha I. Rothschild
J. Cancer 2016; 7(14): 2110-2116. doi:10.7150/jca.16211
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Rac1 overexpression is correlated with epithelial mesenchymal transition and predicts poor prognosis in non-small cell lung cancer
Yujuan Zhou, Qianjin Liao, Yaqian Han, Jie Chen, Zhigang Liu, Hang Ling, Jing Zhang, Wenjuan Yang, Linda Oyang, Longzheng Xia, Li Wang, Heran Wang, Lei Xue, Hui Wang, Bingqiang Hu
J. Cancer 2016; 7(14): 2100-2109. doi:10.7150/jca.16198
[Abstract] [Full text] [PDF] [PubMed] [PMC]

More ...