Editors-in-Chief:
Yan-Gao Man, MD., PhD., Director for Research Laboratory and International Collaboration, Bon Secours Cancer Institute, VA, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
  • new Impact factor is 3.271 according to the 2015 release of Journal Citation Reports.
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...
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Journal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer.

Latest papers:

Research Paper
PD-L1 Expression Is Associated with Tumor FOXP3+ Regulatory T-Cell Infiltration of Breast Cancer and Poor Prognosis of Patient
Zhenhua Li, Pengzhi Dong, Meijing Ren, Yawen Song, Xiaolong Qian, Yiling Yang, Shuai Li, Xinmin Zhang, Fangfang Liu
J. Cancer 2016; 7(7): 784-793. doi:10.7150/jca.14549
[Abstract] [Full text] [PDF]

Research Paper
Phase I/II Trial Evaluating Carbon Ion Radiotherapy for Salvaging Treatment of Locally Recurrent Nasopharyngeal Carcinoma
Lin Kong, Jiyi Hu, Xiyin Guan, Jing Gao, Rong Lu, Jiade J. Lu
J. Cancer 2016; 7(7): 774-783. doi:10.7150/jca.14399
[Abstract] [Full text] [PDF]

Research Paper
HOXC9 Induces Phenotypic Switching between Proliferation and Invasion in Breast Cancer Cells
Ho Hur, Ji-Yeon Lee, Seoyeon Yang, Jie Min Kim, Anna E. Park, Myoung Hee Kim
J. Cancer 2016; 7(7): 768-773. doi:10.7150/jca.13894
[Abstract] [Full text] [PDF]

Research Paper
What is the Prognostic Significance of Ki-67 Positivity in Oral Squamous Cell Carcinoma?
Shang Xie, Ying Liu, Xue Qiao, Rui-Xi Hua, Kan Wang, Xiao-Feng Shan, Zhi-Gang Cai
J. Cancer 2016; 7(7): 758-767. doi:10.7150/jca.14214
[Abstract] [Full text] [PDF]

Research Paper
Silencing of hERG1 Gene Inhibits Proliferation and Invasion, and Induces Apoptosis in Human Osteosarcoma Cells by Targeting the NF-κB Pathway
Wenrong Zeng, Qingjun Liu, Zhida Chen, Xinyu Wu, Yuanfu Zhong, Jin Wu
J. Cancer 2016; 7(6): 746-757. doi:10.7150/jca.13289
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Efficacy of Beta1 Integrin and EGFR Targeting in Sphere-Forming Human Head and Neck Cancer Cells
Katja Zscheppang, Ina Kurth, Nicole Wachtel, Anna Dubrovska, Leoni A. Kunz-Schughart, Nils Cordes
J. Cancer 2016; 7(6): 736-745. doi:10.7150/jca.14232
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Apparent Diffusion Coefficient Quantification in Determining the Histological Diagnosis of Malignant Liver Lesions
Konstantinos Drevelegas, Katerina Nikiforaki, Manolis Constantinides, Nickolas Papanikolaou, Lavrentios Papalavrentios, Ioanna Stoikou, Paul Zarogoulidis, Georgia Pitsiou, Athanasia Pataka, John Organtzis, Eleni Papadaki, Konstantinos Porpodis, Ioanna Kougioumtzi, Ioannis Kioumis, Constantinos Kouskouras, Evaggelos Akriviadis, Antonios Drevelegas
J. Cancer 2016; 7(6): 730-735. doi:10.7150/jca.14197
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Identification of Cathepsin K in the Peritoneal Metastasis of Ovarian Carcinoma Using In-silico, Gene Expression Analysis
Haiming Xu, Yu Ma, Yan Zhang, Zimin Pan, Yan Lu, Pengyuan Liu, Bingjian Lu
J. Cancer 2016; 7(6): 722-729. doi:10.7150/jca.14277
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
CSF2 Overexpression Is Associated with STAT5 Phosphorylation and Poor Prognosis in Patients with Urothelial Carcinoma
Yi-Ying Lee, Wen-Jeng Wu, Chun-Nung Huang, Ching-Chia Li, Wei-Ming Li, Bi-Wen Yeh, Peir-In Liang, Ting-Feng Wu, Chien-Feng Li
J. Cancer 2016; 7(6): 711-721. doi:10.7150/jca.14281
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
ARNT2 Regulates Tumoral Growth in Oral Squamous Cell Carcinoma
Yasushi Kimura, Atsushi Kasamatsu, Dai Nakashima, Masanobu Yamatoji, Yasuyuki Minakawa, Kazuyuki Koike, Kazuaki Fushimi, Morihiro Higo, Yosuke Endo-Sakamoto, Masashi Shiiba, Hideki Tanzawa, Katsuhiro Uzawa
J. Cancer 2016; 7(6): 702-710. doi:10.7150/jca.14208
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Pathologic Diagnosis of Pancreatic Adenocarcinoma in the United States: Its Status and Prognostic Value
Miaozhen Qiu, Huijuan Qiu, Ying Jin, Xiaoli Wei, Yixin Zhou, Zixian Wang, Deshen Wang, Chao Ren, Huiyan Luo, Feng Wang, Dongsheng Zhang, Fenghua Wang, Yuhong Li, Dajun Yang, Ruihua Xu
J. Cancer 2016; 7(6): 694-701. doi:10.7150/jca.14185
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Tyrosine Kinase Inhibitors for the Elderly
Wolfgang Hohenforst-Schmidt, Paul Zarogoulidis, Michael Steinheimer, Naim Benhassen, Theodora Tsiouda, Sofia Baka, Lonny Yarmus, Grigoris Stratakos, John Organtzis, Athanasia Pataka, Kosmas Tsakiridis, Ilias Karapantzos, Chrysanthi Karapantzou, Kaid Darwiche, Athanasios Zissimopoulos, Georgia Pitsiou, Konstantinos Zarogoulidis, Yan-Gao Man, Harald Rittger
J. Cancer 2016; 7(6): 687-693. doi:10.7150/jca.14819
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Effect of Ulcerative Colitis on Incidence of Colorectal Cancer: Results from the Nationwide Population-Based Cohort Study (2003-2013)
Jung-kyu Choi, Dong-Wook Kim, Sang-Yun Shin, Eun-Cheol Park, Jung-Gu Kang
J. Cancer 2016; 7(6): 681-686. doi:10.7150/jca.14264
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Sex Difference of Egfr Expression and Molecular Pathway in the Liver: Impact on Drug Design and Cancer Treatments?
Lishi Wang, Jianqi Xiao, Weikuan Gu, Hong Chen
J. Cancer 2016; 7(6): 671-680. doi:10.7150/jca.13684
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Circulating EBV DNA, Globulin and Nodal Size Predict Distant Metastasis after Intensity-Modulated Radiotherapy in Stage II Nasopharyngeal Carcinoma
Xiao-Jing Du, Ling-Long Tang, Yan-Ping Mao, Rui Guo, Ying Sun, Ai-Hua Lin, Jun Ma
J. Cancer 2016; 7(6): 664-670. doi:10.7150/jca.14183
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
MicroRNA-874 Functions as a Tumor Suppressor by Targeting Cancer/Testis Antigen HCA587/MAGE-C2
Xiao Song, Wenjie Song, Ying Wang, Jingjing Wang, Yan Li, Xiaoping Qian, Xuewen Pang, Yu Zhang, Yanhui Yin
J. Cancer 2016; 7(6): 656-663. doi:10.7150/jca.13674
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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