Editors-in-Chief:
Yan-Gao Man, MD., PhD., Director for Research Laboratory and International Collaboration, Bon Secours Cancer Institute, VA, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
  • new Impact factor is 2.639 according to the 2014 release of Journal Citation Reports.
  • Indexed in SCI Expanded, PubMed and full texts in PubMed Central, Europe PubMed Central, and PMC Canada.
  • High visibility of articles over the Internet.

Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...

Journal of Cancer coverJournal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer. Journal of Cancer is published in cooperation with American Registry of Pathology.

Latest papers:

Review
Utilization of Translational Bioinformatics to Identify Novel Biomarkers of Bortezomib Resistance in Multiple Myeloma
Deanna J. Fall, Holly Stessman, Sagar S. Patel, Zohar Sachs, Brian G. Van Ness, Linda B. Baughn, Michael A. Linden
J. Cancer 2014; 5(9): 720-727. doi:10.7150/jca.9864
[Abstract] [Full text] [PDF]

Review
Salamander Regeneration as a Model for Developing Novel Regenerative and Anticancer Therapies
Jonathan Fior
J. Cancer 2014; 5(8): 715-719. doi:10.7150/jca.9971
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Serum Unsaturated Free Fatty Acids: Potential Biomarkers for Early Detection and Disease Progression Monitoring of Non-Small Cell Lung Cancer
Yaping Zhang, Chengyan He, Ling Qiu, Yanmin Wang, Li Zhang, Xuzhen Qin, Yujie Liu, Dan Zhang, Zhili Li
J. Cancer 2014; 5(8): 706-714. doi:10.7150/jca.9787
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Circulating microRNAs in Pancreatic Juice as Candidate Biomarkers of Pancreatic Cancer
Jin Wang, Massimo Raimondo, Sushovan Guha, Jinyun Chen, Lixia Diao, Xiaoqun Dong, Michael B. Wallace, Ann M. Killary, Marsha L. Frazier, Timothy A. Woodward, Jing Wang, Subrata Sen
J. Cancer 2014; 5(8): 696-705. doi:10.7150/jca.10094
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
The Modified Glasgow Prognostic Score Is an Independent Prognostic Factor in Patients with Inoperable Thoracic Esophageal Squamous Cell Carcinoma Undergoing Chemoradiotherapy
Peng Zhang, Mian Xi, Qiao-Qiao Li, Li-Ru He, Shi-Liang Liu, Lei Zhao, Jing-Xian Shen, Meng-Zhong Liu
J. Cancer 2014; 5(8): 689-695. doi:10.7150/jca.9569
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Photothermal Treatment of Human Pancreatic Cancer Using PEGylated Multi-Walled Carbon Nanotubes Induces Apoptosis by Triggering Mitochondrial Membrane Depolarization Mechanism
Teodora Mocan, Cristian T. Matea, Iulia Cojocaru, Ioana Ilie, Flaviu A. Tabaran, Florin Zaharie, Cornel Iancu, Dana Bartos, Lucian Mocan
J. Cancer 2014; 5(8): 679-688. doi:10.7150/jca.9481
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Preferential Effect of Akt2-Dependent Signaling on the Cellular Viability of Ovarian Cancer Cells in Response to EGF
Dineo Khabele, Syeda M Kabir, Yuanlin Dong, Eunsook Lee, Valerie Montgomery Rice, Deok-Soo Son
J. Cancer 2014; 5(8): 670-678. doi:10.7150/jca.9688
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Serum Carcinoembryonic Antigen Levels and the Risk of Whole-body Metastatic Potential in Advanced Non-small Cell Lung Cancer
Dong Soo Lee, Seung Joon Kim, Jin Hyoung Kang, Sook Hee Hong, Eun Kyoung Jeon, Young Kyoon Kim, Ie Ryoung Yoo, Jae Gil Park, Hong Seok Jang, Hyo Chun Lee, Yeon Sil Kim
J. Cancer 2014; 5(8): 663-669. doi:10.7150/jca.9871
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Down Regulation of FOXO1 Promotes Cell Proliferation in Cervical Cancer
Shyam Babu Prasad, Suresh Singh Yadav, Mitali Das, H. B. Govardhan, Lakshmi Kant Pandey, Sunita Singh, Satyajit Pradhan, Gopeshwar Narayan
J. Cancer 2014; 5(8): 655-662. doi:10.7150/jca.6554
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Gene Expression Analysis of the 26S Proteasome Subunit PSMB4 Reveals Significant Upregulation, Different Expression and Association with Proliferation in Human Pulmonary Neuroendocrine Tumours
Fabian Dominik Mairinger, Robert Fred Henry Walter, Dirk Theegarten, Thomas Hager, Claudia Vollbrecht, Daniel Christian Christoph, Karl Worm, Saskia Ting, Robert Werner, Georgios Stamatis, Thomas Mairinger, Hideo Baba, Konstantinos Zarogoulidis, Haidong Huang, Qiang Li, Kosmas Tsakiridis, Paul Zarogoulidis, Kurt Werner Schmid, Jeremias Wohlschlaeger
J. Cancer 2014; 5(8): 646-654. doi:10.7150/jca.9955
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Gene Expression Analysis Reveals Distinct Pathways of Resistance to Bevacizumab in Xenograft Models of Human ER-Positive Breast Cancer
Yesim Gökmen-Polar, Chirayu P. Goswami, Rachel A. Toroni, Kerry L. Sanders, Rutika Mehta, Usha Sirimalle, Bogdan Tanasa, Changyu Shen, Lang Li, Mircea Ivan, Sunil Badve, George W. Sledge Jr
J. Cancer 2014; 5(8): 633-645. doi:10.7150/jca.8466
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Topotecan Monotherapy in Heavily Pretreated Patients with Progressive Advanced Stage Neuroendocrine Carcinomas
Ingrid Holst Olsen, Ulrich Knigge, Birgitte Federspiel, Carsten Palnæs Hansen, Anna Skov, Andreas Kjær, Seppo W. Langer
J. Cancer 2014; 5(8): 628-632. doi:10.7150/jca.9409
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Short Communication
Phosphodiesterase (PDE)-4 Inhibitors and COPD Correlation with Cancer
John Organtzis, Sofia Lampaki, Paul Zarogoulidis, Haidong Huang, Qiang Li, Antonis Papaiwannou, Konstantinos Syrigos, Konstantinos Porpodis, Theodora Tsiouda, Wolfgang Hohenforst-Schmidt, Georgia Trakada, Robert Fred Henry Walter, Dimitra Makrantonaki, Georgia Pitsiou, Ioannis Kioumis, Konstantinos Zarogoulidis
J. Cancer 2014; 5(8): 625-627. doi:10.7150/jca.9730
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Pyrroloquinoline Quinone Induces Cancer Cell Apoptosis via Mitochondrial-Dependent Pathway and Down-Regulating Cellular Bcl-2 Protein Expression
Zhihui Min, Lingyan Wang, Jianjun Jin, Xiangdong Wang, Bijun Zhu, Hao Chen, Yunfeng Cheng
J. Cancer 2014; 5(7): 609-624. doi:10.7150/jca.9002
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Newly Identified Cancer-Associated Role of Human Neuronal Growth Regulator 1 (NEGR1)
Hyejin Kim, Ji-Sook Hwang, Bogman Lee, Jinpyo Hong, Soojin Lee
J. Cancer 2014; 5(7): 598-608. doi:10.7150/jca.8052
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Transcatheter Arterial Chemoembolization for Intermediate-Stage Hepatocellular Carcinoma: Clinical Outcome and Safety in Elderly Patients
Hiroki Nishikawa, Ryuichi Kita, Toru Kimura, Yoshiaki Ohara, Haruhiko Takeda, Azusa Sakamoto, Sumio Saito, Norihiro Nishijima, Akihiro Nasu, Hideyuki Komekado, Yukio Osaki
J. Cancer 2014; 5(7): 590-597. doi:10.7150/jca.9413
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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