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Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
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Research Paper
Overall survival and post-progression survival are potent endpoint in phase III trials of second/third-line chemotherapy for advanced or recurrent epithelial ovarian cancer
Mototsugu Shimokawa, Takahiro Kogawa, Takako Shimada, Toshiaki Saito, Hozumi Kumagai, Masafumi Ohki, Tsunehisa Kaku
J. Cancer 2018; 9(5): 872-879. doi:10.7150/jca.17664
[Abstract] [Full text] [PDF]

Research Paper
The value of neutrophil-to-lymphocyte ratio for response and prognostic effect of neoadjuvant chemotherapy in solid tumors: A systematic review and meta-analysis
Xuan Li, Danian Dai, Bo Chen, Hailin Tang, Xiaoming Xie, Weidong Wei
J. Cancer 2018; 9(5): 861-871. doi:10.7150/jca.23367
[Abstract] [Full text] [PDF]

Research Paper
Cancer survival in patients from a hospital-based cancer registry, China
Jian-Guo Chen, Hai-Zhen Chen, Jian Zhu, Yan-Lei Yang, Yong-Hui Zhang, Pei-Xin Huang, Yong-Sheng Chen, Chao-Yong Zhu, Li-Ping Yang, Kang Shen, Fu-Lin Qiang, Gao-Ren Wang
J. Cancer 2018; 9(5): 851-860. doi:10.7150/jca.23039
[Abstract] [Full text] [PDF]

Research Paper
Ring finger protein 38 promote non-small cell lung cancer progression by endowing cell EMT phenotype
Dian Xiong, Shu-Qiang Zhu, Yong-Bing Wu, Chun Jin, Jia-Hao Jiang, Yun-Fei Liao, Xiang Long, Hai-Bo Wu, Jian-Jun Xu, Ji-Jun Li, Jian-Yong Ding
J. Cancer 2018; 9(5): 841-850. doi:10.7150/jca.23138
[Abstract] [Full text] [PDF]

Research Paper
Discrimination between malignant and benign mass-like lesions from breast dynamic contrast enhanced MRI: semi-automatic vs. manual analysis of the signal time-intensity curves
Jiandong Yin, Jiawen Yang, Zejun Jiang
J. Cancer 2018; 9(5): 834-840. doi:10.7150/jca.23283
[Abstract] [Full text] [PDF]

Research Paper
A New and Safe Mode of Ventilation for Interventional Pulmonary Medicine: The Ease of Nasal Superimposed High Frequency Jet Ventilation
Wolfgang Hohenforst-Schmidt, Paul Zarogoulidis, Haidong Huang, Yan-Gao Man, Stella Laskou, Charilaos Koulouris, Dimitris Giannakidis, Stylianos Mantalobas, Maria C. Florou, Aikaterini Amaniti, Michael Steinheimer, Anil Sinha, Lutz Freitag, J Francis Turner, Robert Browning, Thomas Vogl, Andrei Roman, Naim Benhassen, Isaak Kesisoglou, Konstantinos Sapalidis
J. Cancer 2018; 9(5): 816-833. doi:10.7150/jca.23737
[Abstract] [Full text] [PDF]

Research Paper
The value of preoperative Glasgow Prognostic Score and the C-Reactive Protein to Albumin Ratio as prognostic factors for long-term survival in pathological T1N0 esophageal squamous cell carcinoma
Xiangyang Yu, Yingsheng Wen, Yongbin Lin, Xuewen Zhang, Yongqiang Chen, Weidong Wang, Gongming Wang, Lanjun Zhang
J. Cancer 2018; 9(5): 807-815. doi:10.7150/jca.22755
[Abstract] [Full text] [PDF]

Research Paper
A Prognostic Score for Nasopharyngeal Carcinoma with Bone Metastasis: Development and Validation from Multicenter
Chen Chen, Jing-Bo Wu, Hao Jiang, Jin Gao, Jia-Xin Chen, Chang-Chuan Pan, Lu-Jun Shen, Yu Chen, Hui Chang, Ya-Lan Tao, Xiao-Hui Li, Pei-Hong Wu, Yun-Fei Xia
J. Cancer 2018; 9(5): 797-806. doi:10.7150/jca.22663
[Abstract] [Full text] [PDF]

Research Paper
Serum expression level of IL-6 at the diagnosis time contributes to the long-term prognosis of SCLC patients
Xi Ding, Jie Zhang, Di Liu, Wen Xu, De-yi Lu, Li-Ping Zhang, Bo Su
J. Cancer 2018; 9(5): 792-796. doi:10.7150/jca.22656
[Abstract] [Full text] [PDF]

Research Paper
The Optimal Application of Transrectal Ultrasound in Staging of Rectal Cancer Following Neoadjuvant Therapy: A Pragmatic Study for Accuracy Investigation
Yufeng Ren, Jinning Ye, Yan Wang, Weixin Xiong, Jianbo Xu, Yulong He, Shirong Cai, Min Tan, Yujie Yuan
J. Cancer 2018; 9(5): 784-791. doi:10.7150/jca.22661
[Abstract] [Full text] [PDF]

Short Research Communication
FOXG1 Expression Is Elevated in Glioma and Inhibits Glioma Cell Apoptosis
Jingying Chen, Xinmin Wu, Zhenkai Xing, Chi Ma, Wencheng Xiong, Xiaojuan Zhu, Xiaoxiao He
J. Cancer 2018; 9(5): 778-783. doi:10.7150/jca.22282
[Abstract] [Full text] [PDF]

Review
Exosomes in Nasopharyngeal Carcinoma
Yujuan Zhou, Longzheng Xia, Jingguan Lin, Heran Wang, Linda Oyang, Shiming Tan, Yutong Tian, Min Su, Hui Wang, Deliang Cao, Qianjin Liao
J. Cancer 2018; 9(5): 767-777. doi:10.7150/jca.22505
[Abstract] [Full text] [PDF]

Research Paper
Upregulation of HES1 Promotes Cell Proliferation and Invasion in Breast Cancer as a Prognosis Marker and Therapy Target via the AKT Pathway and EMT Process
Xiaoying Li, Yu Cao, Mu Li, Feng Jin
J. Cancer 2018; 9(4): 757-766. doi:10.7150/jca.22319
[Abstract] [Full text] [PDF]

Research Paper
Biological Function of Ribosomal Protein L10 on Cell Behavior in Human Epithelial Ovarian Cancer
Jimin Shi, Lingyun Zhang, Daibing Zhou, Jinguo Zhang, Qunbo Lin, Wencai Guan, Jihong Zhang, Weimin Ren, Guoxiong Xu
J. Cancer 2018; 9(4): 745-756. doi:10.7150/jca.21614
[Abstract] [Full text] [PDF]

Research Paper
Niclosamide sensitizes nasopharyngeal carcinoma to radiation by downregulating Ku70/80 expression
Jingjing Li, Haiwen Li, Dechao Zhan, Mei Xiang, Jun Yang, Yufang Zuo, Yin Yu, Hechao Zhou, Danxian Jiang, Haiqing Luo, Zihong Chen, Zhonghua Yu, Zumin Xu
J. Cancer 2018; 9(4): 736-744. doi:10.7150/jca.20963
[Abstract] [Full text] [PDF]

Research Paper
GSTP1 Ile105Val polymorphism might be associated with the risk of radiation pneumonitis among lung cancer patients in Chinese population: A prospective study
Lehui Du, Wei Yu, Xiang Huang, Nana Zhao, Fang Liu, Fang tong, Sujing Zhang, Baolong Niu, Xiaoliang Liu, Shouping Xu, Yurong Huang, Xiangkun Dai, Chuanbin Xie, Gaoxiang Chen, Xiaohu Cong, Baolin Qu
J. Cancer 2018; 9(4): 726-735. doi:10.7150/jca.20643
[Abstract] [Full text] [PDF]

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