Editors-in-Chief:
Yan-Gao Man, MD., PhD., Co-Director, Laboratory of Proteomics and Protein Sciences, Veterans Affair Health System, Baltimore, MD, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...
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Journal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer.


Research Paper
Berberine Enhances Chemosensitivity and Induces Apoptosis Through Dose-orchestrated AMPK Signaling in Breast Cancer
Yue Pan, Fan Zhang, Yawei Zhao, Dan Shao, Xiao Zheng, Yujing Chen, Kan He, Jing Li, Li Chen
J. Cancer 2017; 8(9): 1679-1689. doi:10.7150/jca.19106
[Abstract] [Full text] [PDF]

Research Paper
Nab-paclitaxel as First Line Treatment for NSCLC in Elderly Patients More Than 75 Years Old
Paul Zarogoulidis, Haidong Huang, Chong Bai, Dimitris Petridis, Susana Papadopoulou, Eleni Faniadou, Ellada Eleftheriadou, Georgia Trakada, Kosmidis Cristoforos, Aggeliki Rapti, Lonny Yarmus, David-Feller Kopman, Yan-Gao Man, Wolfgang Hohenforst-Schmidt
J. Cancer 2017; 8(9): 1673-1678. doi:10.7150/jca.19463
[Abstract] [Full text] [PDF]

Research Paper
Evaluation of 7th Edition of AJCC Staging System for Nasopharyngeal Carcinoma
YuFeng Ren, Huizhi Qiu, Yujie Yuan, Jinning Ye, Yunhong Tian, Bixiu Wen, Weijun Zhang, Qun Li
J. Cancer 2017; 8(9): 1665-1672. doi:10.7150/jca.19197
[Abstract] [Full text] [PDF]

Research Paper
Lovastatin Inhibits Cancer Stem Cells and Sensitizes to Chemo- and Photodynamic Therapy in Nasopharyngeal Carcinoma
Yikun Peng, Guangchun He, Da Tang, Li Xiong, Yu Wen, Xiongying Miao, Zhangyong Hong, Hui Yao, Chao Chen, Shichao Yan, Lu Lu, Yingke Yang, Qinglong Li, Xiyun Deng
J. Cancer 2017; 8(9): 1655-1664. doi:10.7150/jca.19100
[Abstract] [Full text] [PDF]

Research Paper
HOXC6 Overexpression Is Associated With Ki-67 Expression and Poor Survival in NPC Patients
Shih-Lun Chang, Ti-Chun Chan, Tzu-Ju Chen, Sung-Wei Lee, Li-Ching Lin, Khin Than Win
J. Cancer 2017; 8(9): 1647-1654. doi:10.7150/jca.18893
[Abstract] [Full text] [PDF]

Research Paper
Integrative Oncology Outpatient Consultations: Long-Term Effects on Patient-Reported Symptoms and Quality of Life
Gabriel Lopez, Wenli Liu, Jennifer McQuade, Richard T Lee, Amy R Spelman, Bryan Fellman, Yisheng Li, Eduardo Bruera, Lorenzo Cohen
J. Cancer 2017; 8(9): 1640-1646. doi:10.7150/jca.18875
[Abstract] [Full text] [PDF]

Research Paper
Thyrospheres from B-CPAP Cell Line with BRAF and TERT Promoter Mutations have Different Functional and Molecular Features than Parental Cells
Paola Caria, Rita Pillai, Tinuccia Dettori, Daniela Virginia Frau, Patrizia Zavattari, Gabriele Riva, Gabriele Romano, Fabiana Pani, Angela Bentivegna, Roberto Giovannoni, Fabio Pagni, Valeria Sogos, Roberta Vanni
J. Cancer 2017; 8(9): 1629-1639. doi:10.7150/jca.18855
[Abstract] [Full text] [PDF]

Review
The Emerging Roles of Forkhead Box (FOX) Proteins in Osteosarcoma
Wentao Zhang, Ning Duan, Tao Song, Zhong Li, Caiguo Zhang, Xun Chen
J. Cancer 2017; 8(9): 1619-1628. doi:10.7150/jca.18778
[Abstract] [Full text] [PDF]

Research Paper
Treatment of Neuroblastoma with an Engineered “Obligate” Anaerobic Salmonella typhimurium Strain YB1
Bo-Tao Ning, Bin Yu, Shing Chan, Jian-liang Chan, Jian-Dong Huang, Godfrey Chi-Fung Chan
J. Cancer 2017; 8(9): 1609-1618. doi:10.7150/jca.18776
[Abstract] [Full text] [PDF]

Research Paper
GSK-3β suppresses HCC cell dissociation in vitro by upregulating epithelial junction proteins and inhibiting Wnt/β-catenin signaling pathway
Jing-Hua Zhang, Li-Yan Jiao, Tie-Jun Li, York Yuanyuan Zhu, Jian-Wei Zhou, Jian Tian
J. Cancer 2017; 8(9): 1598-1608. doi:10.7150/jca.18744
[Abstract] [Full text] [PDF]

Review
Redox Imbalance in the Development of Colorectal Cancer
Hao Liu, Xin Liu, Chundong Zhang, Huifang Zhu, Qian Xu, Youquan Bu, Yunlong Lei
J. Cancer 2017; 8(9): 1586-1597. doi:10.7150/jca.18735
[Abstract] [Full text] [PDF]

Research Paper
Association between PD-L1 Expression on Tumour-Infiltrating Lymphocytes and Overall Survival in Patients with Gastric Cancer
Wenfeng Fang, Ying Chen, Jin Sheng, Ting Zhou, Yaxiong Zhang, Jianhua Zhan, Lin Liu, Jiaxing Huang, Peijian Peng, Li Zhang
J. Cancer 2017; 8(9): 1579-1585. doi:10.7150/jca.18729
[Abstract] [Full text] [PDF]

Research Paper
KCa3.1 as an Effective Target for Inhibition of Growth and Progression of Intrahepatic Cholangiocarcinoma
Penghong Song, Yehui Du, Wenfeng Song, Hao Chen, Zefeng Xuan, Long Zhao, Jun Chen, Jian Chen, Danjing Guo, Cheng Jin, Yongchao Zhao, Biguang Tuo, Shusen Zheng
J. Cancer 2017; 8(9): 1568-1578. doi:10.7150/jca.18697
[Abstract] [Full text] [PDF]

Research Paper
Response Rates as Predictors of Overall Survival: A Meta-Analysis of Acute Myeloid Leukemia Trials
Suresh K. Agarwal, Naveen Mangal, Rajeev Menon, Kevin J. Freise, Ahmed Hamed Salem
J. Cancer 2017; 8(9): 1562-1567. doi:10.7150/jca.18686
[Abstract] [Full text] [PDF]

Research Paper
Vascular Invasion and Stromal S100A4 Expression at the Invasive Front of Colorectal Cancer are Novel Determinants and Tumor Prognostic Markers
Tamotsu Sugai, Noriyuki Yamada, Makoto Eizuka, Ryo Sugimoto, Noriyuki Uesugi, Mitsumasa Osakabe, Kazuyuki Ishida, Kouki Otsuka, Akira Sasaki, Takayuki Matsumoto
J. Cancer 2017; 8(9): 1552-1561. doi:10.7150/jca.18685
[Abstract] [Full text] [PDF]

Research Paper
MicroRNA-765 Enhances the Anti-Angiogenic Effect of CDDP via APE1 in Osteosarcoma
Wei Liang, Xi Wei, Qing Li, Nan Dai, Chong-Yi Li, Yi Deng, Xuan Jiang, Xiao-Rong Tan, Xiao-Yan Dai, Meng-Xia Li, Cheng-Xiong Xu, Dong Wang, Zhao-Yang Zhong
J. Cancer 2017; 8(9): 1542-1551. doi:10.7150/jca.18680
[Abstract] [Full text] [PDF]

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