Editors-in-Chief:
Yan-Gao Man, MD., PhD., Director for Research Laboratory and International Collaboration, Bon Secours Cancer Institute, VA, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
  • new Now indexed in Science Citation Index (SCI) Expanded! Official impact factor expected in June 2014.
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...

Journal of Cancer coverJournal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer. Journal of Cancer is published in cooperation with American Registry of Pathology.

Latest papers:

Research Paper
Predictive Simulation Approach for Designing Cancer Therapeutic Regimens with Novel Biological Mechanisms
Nicole A. Doudican, Amitabha Mazumder, Shweta Kapoor, Zeba Sultana, Ansu Kumar, Anay Talawdekar, Kabya Basu, Ashish Agrawal, Aditi Aggarwal, Krithika Shetty, Neeraj K Singh, Chandan Kumar, Anuj Tyagi, Neeraj Kumar Singh, Janitha C Darlybai, Taher Abbasi, Shireen Vali
J. Cancer 2014; 5(6): 406-416. doi:10.7150/jca.7680
[Abstract] [Full text] [PDF]

Research Paper
Non-Pegylated Liposomal Doxorubicin-Cyclophosphamide in Sequential Regimens with Taxanes as Neoadjuvant Chemotherapy in Breast Cancer Patients
Patrizia Vici, Laura Pizzuti, Teresa Gamucci, Domenico Sergi, Francesca Conti, Germano Zampa, Pietro Del Medico, Roy De Vita, Marcello Pozzi, Claudio Botti, Simona Di Filippo, Federica Tomao, Isabella Sperduti, Luigi Di Lauro
J. Cancer 2014; 5(6): 398-405. doi:10.7150/jca.9132
[Abstract] [Full text] [PDF]

Research Paper
Highly Frequent and Enhanced Injection Site Reaction Induced by Peripheral Venous Injection of Fosaprepitant in Anthracycline-Treated Patients
Yumiko Sato, Masahiro Kondo, Atsushi Inagaki, Hirokazu Komatsu, Chika Okada, Kumi Naruse, Tomoyo Sahashi, Junko Kuroda, Hiroka Ogura, Shiori Uegaki, Tatsuya Yoshida, Yoshinori Mori, Hiroo Sawada, Shoichi Watanabe, Hiroshi Sugiura, Yumi Endo, Nobuyasu Yoshimoto, Tatsuya Toyama, Shinsuke Iida, Koichi Yamada, Kazunori Kimura, Atsushi Wakita
J. Cancer 2014; 5(5): 390-397. doi:10.7150/jca.7706
[Abstract] [Full text] [PDF]

Research Paper
Carnosine Inhibits the Proliferation of Human Gastric Carcinoma Cells by Retarding Akt/mTOR/p70S6K Signaling
Zhenwei Zhang, Lei Miao, Xin Wu, Guangze Liu, Yuting Peng, Xiaoming Xin, Binghua Jiao, Xiangping Kong
J. Cancer 2014; 5(5): 382-389. doi:10.7150/jca.8024
[Abstract] [Full text] [PDF]

Research Paper
Safety and Efficacy of Suicide Gene Therapy with Adenosine Deaminase 5-Fluorocytosine Silmutaneously in in Vitro Cultures of Melanoma and Retinal Cell Lines
Antonios Sakkas, Paul Zarogoulidis, Kalliopi Domvri, Wolfgang Hohenforst-Schmidt, Dimitris Bougiouklis, Stylianos Kakolyris, Thomas Zarampoukas, Ioannis Kioumis, Georgia Pitsiou, Haidong Huang, Qiang Li, Soultana Meditskou, Theodora Tsiouda, Nikolaos Pezirkianidis, Konstantinos Zarogoulidis
J. Cancer 2014; 5(5): 368-381. doi:10.7150/jca.9147
[Abstract] [Full text] [PDF]

Research Paper
Aldehyde Dehydrogenase1 Immunohistochemical Staining in Primary Breast Cancer Cells Independently Predicted Overall Survival But Did Not Correlate with the Presence of Circulating or Disseminated Tumors Cells
Wendy A. Woodward, Savitri Krishnamurthy, Ashutosh Lodhi, Lianchun Xiao, Yun Gong, Massimo Cristofanilli, Thomas A. Buchholz, Anthony Lucci
J. Cancer 2014; 5(5): 360-367. doi:10.7150/jca.7885
[Abstract] [Full text] [PDF]

Research Paper
Phase I and II Study of Gemcitabine and Vinorelbine in Heavily Pretreated Patients with Metastatic Breast Cancer and Review of the Literature
Pamela Abdayem, Marwan Ghosn, Vicente Valero, Ronald Walters, Banu Arun, James L. Murray, Richard Theriault, Debbie Frye, Nuhad K. Ibrahim
J. Cancer 2014; 5(5): 351-359. doi:10.7150/jca.8304
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Enhancement of Aerosol Cisplatin Chemotherapy with Gene Therapy Expressing ABC10 protein in Respiratory System
Wolfgang Hohenforst-Schmidt, Paul Zarogoulidis, Bernd Linsmeier, Ioannis Kioumis, Qiang Li, Haidong Huang, Despoina Sachpatzidou, Sofia Lampaki, John Organtzis, Kalliopi Domvri, Leonidas Sakkas, George A. Zachariadis, Konstantinos N. Archontas, Anastasios Kallianos, Aggeliki Rapti, Lonny Yarmus, Konstantinos Zarogoulidis, Johannes Brachmann
J. Cancer 2014; 5(5): 344-350. doi:10.7150/jca.9021
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Identification of a Novel Compound That Suppresses Breast Cancer Invasiveness by Inhibiting Transforming Growth Factor-β Signaling via Estrogen Receptor α
Natsuka Goto, Hiromi Hiyoshi, Ichiaki Ito, Keisuke Iida, Yuka Nakajima, Kazuo Nagasawa, Junn Yanagisawa
J. Cancer 2014; 5(5): 336-343. doi:10.7150/jca.7202
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Differentiation of Benign Fluid Collections from Soft-Tissue Sarcomas on FDG-PET/CT
Behrang Amini, John E. Madewell, Hubert H. Chuang, Tamara Miner Haygood, Brian P. Hobbs, Patricia S. Fox, Roland L. Bassett, Colleen M. Costelloe
J. Cancer 2014; 5(5): 328-335. doi:10.7150/jca.8310
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Eribulin Mesylate in Pretreated Breast Cancer Patients: A Multicenter Retrospective Observational Study
Teresa Gamucci, Andrea Michelotti, Laura Pizzuti, Lucia Mentuccia, Elisabetta Landucci, Isabella Sperduti, Luigi Di Lauro, Alessandra Fabi, Giuseppe Tonini, Valentina Sini, Nello Salesi, Ilaria Ferrarini, Angela Vaccaro, Ida Pavese, Enzo Veltri, Luca Moscetti, Paolo Marchetti, Patrizia Vici
J. Cancer 2014; 5(5): 320-327. doi:10.7150/jca.8748
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
The “Cavitary” Type of Angiogenesis by Gastric Cancer. Morphological Characteristics and Prognostic Value
Marina Senchukova, Mikhail V. Kiselevsky
J. Cancer 2014; 5(5): 311-319. doi:10.7150/jca.8716
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Investigating Molecular Profiles of Ovarian Cancer: An Update on Cancer Stem Cells
Federica Tomao, Anselmo Papa, Martina Strudel, Luigi Rossi, Giuseppe Lo Russo, Pierluigi Benedetti Panici, Francesca Romana Ciabatta, Silverio Tomao
J. Cancer 2014; 5(5): 301-310. doi:10.7150/jca.8610
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Future Directions for the Early Detection of Recurrent Breast Cancer
Erika J. Schneble, Lindsey J. Graham, Matthew P. Shupe, Frederick L. Flynt, Kevin P. Banks, Aaron D. Kirkpatrick, Aviram Nissan, Leonard Henry, Alexander Stojadinovic, Nathan M. Shumway, Itzhak Avital, George E. Peoples, Robert F. Setlik
J. Cancer 2014; 5(4): 291-300. doi:10.7150/jca.8017
[Abstract] [Full text] [PDF]

Review
Current Approaches and Challenges in Early Detection of Breast Cancer Recurrence
Erika J. Schneble, Lindsey J. Graham, Matthew P. Shupe, Frederick L. Flynt, Kevin P. Banks, Aaron D. Kirkpatrick, Aviram Nissan, Leonard Henry, Alexander Stojadinovic, Nathan M. Shumway, Itzhak Avital, George E. Peoples, Robert F. Setlik
J. Cancer 2014; 5(4): 281-290. doi:10.7150/jca.8016
[Abstract] [Full text] [PDF]

Review
Future Directions for the Early Detection of Colorectal Cancer Recurrence
Avery S. Walker, Eric K. Johnson, Justin A. Maykel, Alex Stojadinovic, Aviram Nissan, Bjorn Brucher, Bradley J. Champagne, Scott R. Steele
J. Cancer 2014; 5(4): 272-280. doi:10.7150/jca.8871
[Abstract] [Full text] [PDF]

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