Editors-in-Chief:
Yan-Gao Man, MD., PhD., Director for Research Laboratory and International Collaboration, Bon Secours Cancer Institute, VA, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
  • new Impact factor is 2.639 according to the 2014 release of Journal Citation Reports.
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...
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Journal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer. Journal of Cancer is published in cooperation with American Registry of Pathology.

Latest papers:

Research Paper
Association of Body Mass Index Changes during Neoadjuvant Chemotherapy with Pathologic Complete Response and Clinical Outcomes in Patients with Locally Advanced Breast Cancer
Takahiro Kogawa, Tamer M. Fouad, Caimiao Wei, Hiroko Masuda, Kazuharu Kai, Takeo Fujii, Randa El-Zein, Mariana Chavez-MacGregor, Jennifer K. Litton, Abenaa Brewster, Ricardo H. Alvarez, Gabriel N. Hortobagyi, Vicente Valero, Richard Theriault, Naoto T. Ueno
J. Cancer 2015; 6(4): 310-318. doi:10.7150/jca.10580
[Abstract] [Full text] [PDF]

Research Paper
Association between CYP1A1 Ile462Val Polymorphism and Oral Squamous Cell Carcinoma Susceptibility: Evidence from 13 Investigations
Xiao-Lei Yang, Shang Xie, Yi-Yan Jiang, Chang Shi, Zhi-Gang Cai, Su-Xiu Chen
J. Cancer 2015; 6(4): 302-309. doi:10.7150/jca.11036
[Abstract] [Full text] [PDF]

Research Paper
Controlling RECK miR21 Promotes Tumor Cell Invasion and Is Related to Biochemical Recurrence in Prostate Cancer
Katia R. M. Leite, Sabrina T. Reis, Nayara Viana, Denis R. Morais, Caio M. Moura, Iran A. Silva, José Pontes Jr, Betina Katz, Miguel Srougi
J. Cancer 2015; 6(3): 292-301. doi:10.7150/jca.11038
[Abstract] [Full text] [PDF]

Research Paper
Complementary Roles of Squamous Cell Carcinoma Antigen and 18F-FDG PET/CT in Suspected Recurrence of Cervical Squamous Cell Cancer
Ying-Ying Hu, Wei Fan, Xu Zhang, Pei-Yan Liang, Xiao-Ping Lin, Ya-Rui Zhang, Yuan-Hua Li
J. Cancer 2015; 6(3): 287-291. doi:10.7150/jca.10819
[Abstract] [Full text] [PDF]

Research Paper
Intracellular Acidosis Promotes Mitochondrial Apoptosis Pathway: Role of EMMPRIN Down-regulation via Specific Single-chain Fv Intrabody
Patcharin Thammasit, Sirikwan Sangboonruang, Supattara Suwanpairoj, Wannisa Khamaikawin, Nutjeera Intasai, Watchara Kasinrerk, Chatchai Tayapiwatana, Khajornsak Tragoolpua
J. Cancer 2015; 6(3): 276-286. doi:10.7150/jca.10879
[Abstract] [Full text] [PDF]

Research Paper
Amplification of Chromosome 8 Genes in Lung Cancer
Onur Baykara, Burak Bakir, Nur Buyru, Kamil Kaynak, Nejat Dalay
J. Cancer 2015; 6(3): 270-275. doi:10.7150/jca.10638
[Abstract] [Full text] [PDF]

Research Paper
Number of Negative Lymph Nodes Can Predict Survival after Postmastectomy Radiotherapy According to Different Breast Cancer Subtypes
San-Gang Wu, Fang Peng, Juan Zhou, Jia-Yuan Sun, Feng-Yan Li, Qin Lin, Huan-Xin Lin, Yong Bao, Zhen-Yu He
J. Cancer 2015; 6(3): 261-269. doi:10.7150/jca.10402
[Abstract] [Full text] [PDF]

Research Paper
The Prognostic Value of Irradiated Lung Volumes on the Prediction of Intra-/ Post-Operative Mortality in Patients after Neoadjuvant Radiochemotherapy for Esophageal Cancer. A Retrospective Multicenter Study.
Philipp Günther Kup, Carsten Nieder, Hans Geinitz, Christoph Henkenberens, Angela Besserer, Markus Oechsner, Sabine Schill, Ralph Mücke, Vera Scherer, Stephanie E. Combs, Irenäus A. Adamietz, Khashayar Fakhrian
J. Cancer 2015; 6(3): 254-260. doi:10.7150/jca.10796
[Abstract] [Full text] [PDF]

Research Paper
Non-invasive Analysis of Genomic Copy Number Variation in Patients with Hepatocellular Carcinoma by Next Generation DNA Sequencing
Hongtao Xu, Xia Zhu, Zulong Xu, Yue Hu, Shiping Bo, Tongjing Xing, Kuichun Zhu
J. Cancer 2015; 6(3): 247-253. doi:10.7150/jca.10747
[Abstract] [Full text] [PDF]

Research Paper
Management of Inguinal Involvement of Peritoneal Surface Malignancies by Cytoreduction and HIPEC with Inguinal Perfusion
Yair Shachar, Mohamed Adileh, Assaf Keidar, Luminita Eid, Ayalah Hubert, Mark Temper, Salah Azam, Alex Beny, Tal Grednader, Abed Khalaileh, Jonathan B. Yuval, Alexander Stojadinovic, Itzhak Avital, Aviram Nissan
J. Cancer 2015; 6(3): 243-246. doi:10.7150/jca.10325
[Abstract] [Full text] [PDF]

Review
Cullin Family Proteins and Tumorigenesis: Genetic Association and Molecular Mechanisms
Zhi Chen, Jie Sui, Fan Zhang, Caiguo Zhang
J. Cancer 2015; 6(3): 233-242. doi:10.7150/jca.11076
[Abstract] [Full text] [PDF]

Short Research Communication
MicroRNA-210 and Endoplasmic Reticulum Chaperones in the Regulation of Chemoresistance in Glioblastoma
Derek Lee, Stella Sun, Xiao Qin Zhang, Ping De Zhang, Amy S.W. Ho, Karrie M.Y. Kiang, Ching Fai Fung, Wai Man Lui, Gilberto K.K. Leung
J. Cancer 2015; 6(3): 227-232. doi:10.7150/jca.10765
[Abstract] [Full text] [PDF]

Research Paper
Enhancement of Intratumoral Chemotherapy with Cisplatin with or without Microwave Ablation and Lipiodol. Future Concept for Local Treatment in Lung Cancer
Wolfgang Hohenforst-Schmidt, Paul Zarogoulidis, Joshua Stopek, Efstratios Kosmidis, Thomas Vogl, Bernd Linsmeier, Kosmas Tsakiridis, Sofia Lampaki, George Lazaridis, Andreas Mpakas, Robert Browning, Antonis Papaiwannou, Antonis Drevelegas, Sofia Baka, Vasilis Karavasilis, Ioannis Mpoukovinas, J Francis Turner, Konstantinos Zarogoulidis, Johannes Brachmann
J. Cancer 2015; 6(3): 218-226. doi:10.7150/jca.10970
[Abstract] [Full text] [PDF]

Review
Immune Suppression during Oncolytic Virotherapy for High-Grade Glioma; Yes or No?
Carolien A.E. Koks, Steven De Vleeschouwer, Norbert Graf, Stefaan W. Van Gool
J. Cancer 2015; 6(3): 203-217. doi:10.7150/jca.10640
[Abstract] [Full text] [PDF]

Research Paper
Clinico-Pathological Correlation of β-Catenin and Telomere Dysfunction in Head and Neck Squamous Cell Carcinoma Patients
Swatishree Padhi, Arka Saha, Madhabananda Kar, Chinmoy Ghosh, Amit Adhya, Manas Baisakh, Nachiketa Mohapatra, Shriram Venkatesan, Manoor Prakash Hande, Birendranath Banerjee
J. Cancer 2015; 6(2): 192-202. doi:10.7150/jca.9558
[Abstract] [Full text] [PDF]

Research Paper
MiR-217 Promotes Tumor Proliferation in Breast Cancer via Targeting DACH1
Qiang Zhang, Yonghui Yuan, Jianchun Cui, Tingting Xiao, Daqing Jiang
J. Cancer 2015; 6(2): 184-191. doi:10.7150/jca.10822
[Abstract] [Full text] [PDF]

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