ZFP57 promotes ovarian cancer progression by transcriptionally regulating BRCA1 and managing G1 checkpoint

Fan, Weirong; Xiong, Rui; Zhou, Ziyang; Zhang, Cancan; Han, Yanli; Shi, Tingyan; Qiu, Jianping; Zhang, Rong

doi:10.7150/jca.84601

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International Journal of Medical Sciences

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Journal of Genomics

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J Cancer 2023; 14(11):2039-2050. doi:10.7150/jca.84601 This issue Cite

Research Paper

ZFP57 promotes ovarian cancer progression by transcriptionally regulating BRCA1 and managing G1 checkpoint

Weirong Fan^1,2#, Rui Xiong^1,2#, Ziyang Zhou^2#, Cancan Zhang², Yanli Han², Tingyan Shi³, Jianping Qiu^4✉, Rong Zhang^2✉

1. The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.
2. Department of Obstetrics and Gynecology, Fengxian Hospital Affiliated to the Southern Medical University, Shanghai, China.
3. Department of Gynecologic Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.
4. The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China.
# These authors have contributed equally to this work.

Citation:

Fan W, Xiong R, Zhou Z, Zhang C, Han Y, Shi T, Qiu J, Zhang R. ZFP57 promotes ovarian cancer progression by transcriptionally regulating BRCA1 and managing G1 checkpoint. J Cancer 2023; 14(11):2039-2050. doi:10.7150/jca.84601. https://www.jcancer.org/v14p2039.htm

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Abstract

Ovarian cancer (OC) which is one of the frequently-occurring gynecologic malignant tumors, endangers the health of women. The zinc finger protein 57 (ZFP57) plays crucial functions during the progression of cancer and is reported as a prognostic and therapeutic candidate in a variety of cancer. However, the biological function as well as the underlying mechanism of ZFP57 during OC progression remains unknown. Here, ZFP57 expression was found prominently increased in OC tissues and correlated with the prognosis of OC patients. Knock down of ZFP57 in OC cells inhibited the cell proliferation and migration, and also arrested the cells at G1 phase as well as accelerated the apoptosis. Additionally, ZFP57 transcriptionally regulated BRCA1 expression in OC, indicating that ZFP57 may affect BRCA1 mediated G1 checkpoint to regulate the cell cycle of OC cells and further influence the progression of OC. Taken together, our present study discovered a novel function of ZFP57 in OC, suggesting that ZFP57 could be potentially treated as a prognostic biomarker and therapeutic target for OC patients.

Keywords: Ovarian cancer, ZFP57, BRCA1, G1 checkpoint, Biomarker

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APA

Fan, W., Xiong, R., Zhou, Z., Zhang, C., Han, Y., Shi, T., Qiu, J., Zhang, R. (2023). ZFP57 promotes ovarian cancer progression by transcriptionally regulating BRCA1 and managing G1 checkpoint. Journal of Cancer, 14(11), 2039-2050. https://doi.org/10.7150/jca.84601.

ACS

Fan, W.; Xiong, R.; Zhou, Z.; Zhang, C.; Han, Y.; Shi, T.; Qiu, J.; Zhang, R. ZFP57 promotes ovarian cancer progression by transcriptionally regulating BRCA1 and managing G1 checkpoint. J. Cancer 2023, 14 (11), 2039-2050. DOI: 10.7150/jca.84601.

NLM

CSE

Fan W, Xiong R, Zhou Z, Zhang C, Han Y, Shi T, Qiu J, Zhang R. 2023. ZFP57 promotes ovarian cancer progression by transcriptionally regulating BRCA1 and managing G1 checkpoint. J Cancer. 14(11):2039-2050.

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