J Cancer
2020; 11(23):6950-6959.
doi:10.7150/jca.48998 This issueCite
Research Paper
Identification of hsa_circ_0039053 as an up-regulated and oncogenic circRNA in hepatocellular carcinoma via the miR-637-mediated USP21 activation
Tian Bao Yang, Fang Yi, Wei Feng Liu, Yan Hui Yang, Cheng Yang, Junjun Sun✉
Department of Hepatobiliary Surgery, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China, 471003.
✉ Corresponding author: Junjun Sun; Department of Hepatobiliary Surgery, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, No.24 Jinghua Road, Luoyang 471003, Henan China. E-mail: skyprotect315com or doctoryangedu.cn.More
Citation:
Yang TB, Yi F, Liu WF, Yang YH, Yang C, Sun J. Identification of hsa_circ_0039053 as an up-regulated and oncogenic circRNA in hepatocellular carcinoma via the miR-637-mediated USP21 activation. J Cancer 2020; 11(23):6950-6959. doi:10.7150/jca.48998. https://www.jcancer.org/v11p6950.htm
Accumulating evidence indicated that circular RNAs (circRNAs) are crucial regulators in tumorigenesis of hepatocellular carcinoma (HCC), but it is still unclear how hsa_circ_0039053 causes HCC. Herein, hsa_circ_0039053 was upregulated in HCC tissues and cell lines. The upregulation of hsa_circ_0039053 was linked to the advanced clinical characteristics of patients. Downregulation of hsa_circ_0039053 decreased the invasion and proliferative ability of tumors in vitro and as well as tumor growth in vivo. Mechanically, hsa_circ_0039053 positively regulated USP21 expression through interacting with miR-637. Moreover, overexpression of USP21 or silencing of miR-637 restored the inhibitory impacts of hsa_circ_0039053 silencing on HCC progression. Collectively, our study confirmed that hsa_circ_0039053 could be regarded as a competing endogenous RNA (ceRNA) to positively modulate the expression of USP21 combining with miR-637, which provided a potential target in HCC treatment.
Yang, T.B., Yi, F., Liu, W.F., Yang, Y.H., Yang, C., Sun, J. (2020). Identification of hsa_circ_0039053 as an up-regulated and oncogenic circRNA in hepatocellular carcinoma via the miR-637-mediated USP21 activation. Journal of Cancer, 11(23), 6950-6959. https://doi.org/10.7150/jca.48998.
ACS
Yang, T.B.; Yi, F.; Liu, W.F.; Yang, Y.H.; Yang, C.; Sun, J. Identification of hsa_circ_0039053 as an up-regulated and oncogenic circRNA in hepatocellular carcinoma via the miR-637-mediated USP21 activation. J. Cancer 2020, 11 (23), 6950-6959. DOI: 10.7150/jca.48998.
NLM
Yang TB, Yi F, Liu WF, Yang YH, Yang C, Sun J. Identification of hsa_circ_0039053 as an up-regulated and oncogenic circRNA in hepatocellular carcinoma via the miR-637-mediated USP21 activation. J Cancer 2020; 11(23):6950-6959. doi:10.7150/jca.48998. https://www.jcancer.org/v11p6950.htm
CSE
Yang TB, Yi F, Liu WF, Yang YH, Yang C, Sun J. 2020. Identification of hsa_circ_0039053 as an up-regulated and oncogenic circRNA in hepatocellular carcinoma via the miR-637-mediated USP21 activation. J Cancer. 11(23):6950-6959.
This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
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