J Cancer 2019; 10(6):1393-1397. doi:10.7150/jca.29530

Short Research Communication

High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma

Michal Tichý1*, Lucia Knopfová2,3*, Jiří Jarkovský4, Petr Vlček5, Jana Katolická6, Ivan Čapov5, Markéta Hermanová1, Jan Šmarda2, Petr Beneš2,3✉

1. First Department of Pathological Anatomy, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic
2. Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
3. International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic
4. Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic
5. 1st Department of Surgery, St. Anne's University Hospital Brno, Czech Republic
6. Department of Oncology, St. Anne's University Hospital Brno, Czech Republic
*These authors contributed equally to this work.

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Citation:
Tichý M, Knopfová L, Jarkovský J, Vlček P, Katolická J, Čapov I, Hermanová M, Šmarda J, Beneš P. High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma. J Cancer 2019; 10(6):1393-1397. doi:10.7150/jca.29530. Available from http://www.jcancer.org/v10p1393.htm

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Abstract

Colorectal cancer (CRC) represents a serious challenge for oncologists due to high incidence and large heterogeneity. Prognostic factors are needed to stratify patients according to risk of disease progression. In this study, we report that high expression of c-Myb protein, determined by immunohistochemistry (IHC), associates with better overall and disease-free survival (OS, DFS) in a cohort of 103 patients. Although MYB has been previously considered to act as oncogene in CRC, our further analysis of datasets deposited in PrognoScan and SurvExpress databases confirmed that high MYB expression largely associates with good prognosis in CRC. As therapies targeting c-Myb have been developed and tested in preclinical studies, we believe that further studies are needed for detailed understanding of c-Myb function in CRC, before the c-Myb-targeted therapy enters clinical trials.

Keywords: c-Myb, colorectal cancer, prognosis, survival