J Cancer 2018; 9(17):3109-3116. doi:10.7150/jca.25235

Research Paper

The relationship between miR-302b and EphA2 and their clinical significance in gastric cancer

Lanhua Tang1*, Huabin Hu2*, Yijing He3, Howard L. Mcleod3,4,5, Desheng Xiao6, Pan Chen7, Liangfang Shen1, Shan Zeng1, Xianli Yin8, Jie Ge9, Li Li1, Jian Ma10, Zihua Chen9, Jin Huang1✉

1. Department of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, China
2. The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510655, China
3. Department of Dermatology, XiangYa Hospital, Central South University, Changsha, 410008, China
4. Department of Clinical Pharmacology, XiangYa Hospital, Central South University, Changsha, 410008, China
5. Moffitt Cancer Center, DeBartolo Family Personalized Medicine Institute, Tampa, FL 33612, USA
6. Department of Pathology, Xiangya Hospital, Central South University, Changsha, 410008, China
7. Department of Hepatobiliary Surgery, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China
8. Department of gastroenterology and urology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013,China
9. Department of General Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China
10. Cancer Research Institute, Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Central South University, Changsha, 410008, China.
* Lanhua Tang and Huabin Hu contributed equally to this work

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Citation:
Tang L, Hu H, He Y, Mcleod HL, Xiao D, Chen P, Shen L, Zeng S, Yin X, Ge J, Li L, Ma J, Chen Z, Huang J. The relationship between miR-302b and EphA2 and their clinical significance in gastric cancer. J Cancer 2018; 9(17):3109-3116. doi:10.7150/jca.25235. Available from http://www.jcancer.org/v09p3109.htm

File import instruction

Abstract

Introduction: EphA2 is a crucial oncogene in gastric cancer (GC) development and metastasis, and miR-302b can target EphA2 in gastric cancer. This study plans to investigate their relationship and clinical significance in clinical samples.

Materials and Methods: We explored the correlation of the expression of EphA2 and miR-302b, and their clinical significance in the training (n=226) cohort of GC patients, and then validated the results in the validation (n=128) cohort.

Results: miR-302b was remarkably downregulated in GC tissues, while high EphA2 expression were detected, and they were inversely correlated both in mRNA and protein, (r=-0.4209, P<0.0001; r=-0.336, P <0.001, respectively). Furthermore, the pattern of high EphA2 and low miR-302b expression were found to be associated with poor overall survival in stage IV GC patients in both training and validation cohort.

Conclusions: The expression of miR-302b and EphA2 was inversely correlated, and had prognostic significance on GC in clinic.

Keywords: miR-302b, EphA2, gastric cancer