J Cancer 2018; 9(16):2802-2806. doi:10.7150/jca.25614

Research Paper

Prevalence and Distribution of HPV Genotypes in 1387 Women with Cervical Intraepithelial Neoplasia 2/3 in Shanxi Province, China

Zhilian Wang1, Zaibo Li2, Jing Li1, Chen Wang1, Wenhao Wang1, Min Hao1, Chengquan Zhao3✉

1. Department of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan, China.
2. Department of Pathology, Ohio State Wexner Medical Center, Columbus, OH 43210, USA.
3. Department of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center. 300 Halket St, Pittsburgh, PA, 15213, USA.

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Citation:
Wang Z, Li Z, Li J, Wang C, Wang W, Hao M, Zhao C. Prevalence and Distribution of HPV Genotypes in 1387 Women with Cervical Intraepithelial Neoplasia 2/3 in Shanxi Province, China. J Cancer 2018; 9(16):2802-2806. doi:10.7150/jca.25614. Available from http://www.jcancer.org/v09p2802.htm

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Abstract

Objective: The distribution of human papillomavirus (HPV) genotypes varies by countries and regions. Data regarding HPV genotype distribution for women with cervical intraepithelial neoplasia 2/3 (CIN2/3) are still limited. This study aimed to investigate the distribution of HPV genotypes for women with CIN2/3 in Shanxi province, China.

Methods: Prior HPV testing/genotyping resulted from women with histologic diagnosis of CIN2/3 were retrospectively collected between August 2011 and August 2016.

Results: A total of 1387 women with a diagnosis of CIN2/3 were included in this study. The average age of the women was 45.7 years and the average time period from HPV testing to histological diagnosis was 0.4 months. The overall high-risk HPV (hrHPV) positive rate was 91.6%. In all tested women, the most commonly detected hrHPV genotype was HPV16 (59.3%) followed by HPV58 (14.4%) and HPV33 (10.0%), while HPV18 was in the 6th position (6.0%).

Conclusions: This is one of the largest studies of HPV genotyping for women with CIN2/3 in China. The prevalence and distribution of HPV genotypes in these Chinese women differed from those in women from Western countries. Our results provide important information for developing specific HPV vaccines for Chinese women.

Keywords: HPV genotyping, Neoplasia 2/3, Prevalence