ISSN: 1837-9664Journal of Cancer
Global reach, higher impact
J Cancer 2018; 9(5):901-905. doi:10.7150/jca.21511 This issue Cite
Research Paper
Characteristics and Treatment of Brain Metastases from Esophageal Squamous Cell Carcinoma
1. State Key Laboratory of Oncology in South China, Guangdong Esophageal Cancer Institute; Collaborative Innovation Center for Cancer Medicine, Guangzhou, China;
2. Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, China;
* authors contributed equally to this work.
Abstract
Brain metastasis is very rare in esophageal squamous cell carcinoma (ESCC). We retrospectively analyzed 4494 patients diagnosed with ESCC between 2010 and 2015 at a single institute; 15 of these patients developed brain metastases. All 15 patients had neurologic symptoms and were diagnosed by imaging or biology. Of the 15 patients, 67% had a solitary brain lesion and 73% had lesions larger than 3 cm. After treatment of the brain lesions, including surgery (53%) or stereotactic radiotherapy with or without whole brain radiation (20%), the median progression free survival time and the 2-year overall survival rate calculated from diagnosis of brain metastasis were 14.4 months and 36%, respectively. A graded prognostic assessment (GPA) score > 2.0 was associated with significantly better overall survival. Patients with brain metastases from ESCC achieve good overall survival after appropriate treatment of the brain lesion(s); GPA score may represent a prognostic factor for treatment decision-making.
Keywords: esophageal squamous cell carcinoma, bran metastases, survival, treatment
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