J Cancer 2017; 8(16):3268-3273. doi:10.7150/jca.21555
Fluid intake-to-bed time, nocturia frequency and the risk of urothelial carcinoma of the bladder: a case-control study
1. Department of Urology, Qilu Hospital of Shandong University, Jinan, 250012 P.R. China;
2. Department of First Operating Room, Qilu Hospital of Shandong University, Jinan, 250012 P.R. China;
3. Department of Radiation Oncology, Shandong Cancer Hospital and Institute affiliated to Shandong University, Jinan, P.R. China;
4. Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012 P.R. China.
Cui J, Bo Q, Zhang N, Chen S, Yu M, Wang S, Han J, Chen P, Zhang D, Zhu Y, Shi B. Fluid intake-to-bed time, nocturia frequency and the risk of urothelial carcinoma of the bladder: a case-control study. J Cancer 2017; 8(16):3268-3273. doi:10.7150/jca.21555. Available from http://www.jcancer.org/v08p3268.htm
Objectives: To clarify the potential role of fluid intake-to-bed time and nocturia frequency on bladder cancer risk in a hospital-based case-control study with Chinese people.
Materials and Methods: Four hundred and seven patients with histologically diagnosed bladder cancer and 400 matched controls were enrolled in this study. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression model.
Results: After adjustment for potential confounders, the fluid intake-to-bed time was associated with a decreased risk of BCa, with an OR of 0.586 (95% CI= 0.375-0.916, ≤1h) and 0.257 (95% CI= 0.162-0.407, >1h). The adjusted OR of BCa for subjects with more nocturia frequency (≥2 times) was 2.268 (95 % CI= 1.481-3474), compared to those with no nocturia.
Conclusion: We suggested strong protective effect of long fluid intake-to-bed time on BCa risk, especially in ones with ≥2 times nocturia frequency. These results provide evidence for identifying high-risk individuals and modifying their behaviors and lifestyle.
Keywords: bladder cancer, case-control study, fluid intake-to-bed time, nocturia