J Cancer 2016; 7(5):576-586. doi:10.7150/jca.13117
High Expression of the Newly Found Long Noncoding RNA Z38 Promotes Cell Proliferation and Oncogenic Activity in Breast Cancer
1. College of Biology, Hunan University, Changsha, Hunan 410082, China;
2. Department of Biological Engineering, Zunyi Medical College, Zhuhai Campus, Zhuhai, Guangdong 519041, China;
3. College of Life Science, Hunan Normal University, Changsha, Hunan 410000, China;
4. Faculty of Basic Medical Sciences, Medical College, Hunan Normal University, Changsha, Hunan 410013, China.
Deng R, Liu B, Wang Y, Yan F, Hu S, Wang H, Wang T, Li B, Deng X, Xiang S, Yang Y, Zhang J. High Expression of the Newly Found Long Noncoding RNA Z38 Promotes Cell Proliferation and Oncogenic Activity in Breast Cancer. J Cancer 2016; 7(5):576-586. doi:10.7150/jca.13117. Available from http://www.jcancer.org/v07p0576.htm
The aberrant expression of long noncoding RNAs (lncRNAs) has great impacts on cancer origination and progression. In the current study, a newly found lncRNA Z38, which was identified through combining experiments of suppression subtractive hybridization (SSH) and reverse dot-blotting, was found to have high expression in breast cancer. More importantly, inhibiting Z38 expression by gene silencing greatly suppressed breast cancer cell proliferation and tumorigenesis, and treatment with Z38 siRNAs significantly induced cell apoptosis and inhibited tumor growth. In conclusion, the newly found lncRNA Z38, which plays important roles in breast cancer, may act as a candidate biomarker and therapeutic target in carcinomas.
Keywords: lncRNA Z38, CLDND1, cell proliferation, tumorigenesis, oncogene, siRNA.