Kinetics of Circulating Plasma Cell-Free DNA in Paediatric Classical Hodgkin Lymphoma

Primerano, Simona; Burnelli, Roberta; Carraro, Elisa; Pillon, Marta; Elia, Caterina; Farruggia, Piero; Sala, Alessandra; Vinti, Luciana; Buffardi, Salvatore; Basso, Giuseppe; Mascarin, Maurizio; Mussolin, Lara

doi:10.7150/jca.13593

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J Cancer 2016; 7(4):364-366. doi:10.7150/jca.13593 This issue Cite

Short Research Communication

Kinetics of Circulating Plasma Cell-Free DNA in Paediatric Classical Hodgkin Lymphoma

Simona Primerano¹, Roberta Burnelli², Elisa Carraro¹, Marta Pillon¹, Caterina Elia³, Piero Farruggia⁴, Alessandra Sala⁵, Luciana Vinti⁶, Salvatore Buffardi⁷, Giuseppe Basso¹, Maurizio Mascarin^3*, Lara Mussolin^1,8*✉

1. Clinica di Oncoematologia Pediatrica, Dipartimento Salute della Donna e del Bambino, Azienda Ospedaliera-Universita' di Padova, Padova;
2. Unita' di Oncoematologia, Azienda Ospedaliero-Universitaria di Ferrara S.Anna, Ferrara;
3. SOS di Radioterapia Pediatrica CRO Aviano;
4. Dipartimento di Oncologia, Unita' di Oncoematologia Pediatrica, A.R.N.A.S. Ospedali Civico di Cristina e Benfratelli, Palermo;
5. Clinica Pediatrica, Università di Milano-Bicocca, Ospedale S.Gerardo, Fondazione Monza e Brianza per il Bambino e la sua Mamma, Monza;
6. Dipartimento di Oncoematologia Pediatrica, Ospedale Bambino Gesu', Roma;
7. Dipartimento di Oncologia Pediatrica, Ospedale Santobono-Pausillipon, Napoli;
8. Istituto di Ricerca Pediatrica-Fondazione Città della Speranza, Padova.
*co-last authors

Citation:

Primerano S, Burnelli R, Carraro E, Pillon M, Elia C, Farruggia P, Sala A, Vinti L, Buffardi S, Basso G, Mascarin M, Mussolin L. Kinetics of Circulating Plasma Cell-Free DNA in Paediatric Classical Hodgkin Lymphoma. J Cancer 2016; 7(4):364-366. doi:10.7150/jca.13593. https://www.jcancer.org/v07p0364.htm

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Abstract

Levels of plasma cell-free DNA (cfDNA) of a large series of children with classical Hodgkin lymphoma (cHL) were evaluated and analyzed at diagnosis and during chemotherapy treatment in relation with clinical characteristics. CfDNA levels in cHL patients were significantly higher compared with controls (p=0.002). CfDNA at diagnosis was correlated with presence of B symptoms (p=0.027) and high erythrocyte sedimentation rate (p=0.049). We found that the increasing of plasma cfDNA after first chemotherapy cycle seems to be associated with a worse prognosis (p=0.049). Levels of plasma cfDNA might constitute an interesting non-invasive tool in cHL patients' management.

Keywords: classical Hodgkin Lymphoma, cell-free DNA, childhood.

Citation styles

APA

Primerano, S., Burnelli, R., Carraro, E., Pillon, M., Elia, C., Farruggia, P., Sala, A., Vinti, L., Buffardi, S., Basso, G., Mascarin, M., Mussolin, L. (2016). Kinetics of Circulating Plasma Cell-Free DNA in Paediatric Classical Hodgkin Lymphoma. Journal of Cancer, 7(4), 364-366. https://doi.org/10.7150/jca.13593.

ACS

Primerano, S.; Burnelli, R.; Carraro, E.; Pillon, M.; Elia, C.; Farruggia, P.; Sala, A.; Vinti, L.; Buffardi, S.; Basso, G.; Mascarin, M.; Mussolin, L. Kinetics of Circulating Plasma Cell-Free DNA in Paediatric Classical Hodgkin Lymphoma. J. Cancer 2016, 7 (4), 364-366. DOI: 10.7150/jca.13593.

NLM

CSE

Primerano S, Burnelli R, Carraro E, Pillon M, Elia C, Farruggia P, Sala A, Vinti L, Buffardi S, Basso G, Mascarin M, Mussolin L. 2016. Kinetics of Circulating Plasma Cell-Free DNA in Paediatric Classical Hodgkin Lymphoma. J Cancer. 7(4):364-366.

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