Journal of Cancer

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Research Paper Epidemiological Trends and Shared Molecular Signatures of Pancreatic Ductal Adenocarcinoma and Diabetes: An Integrative Analysis Based on Global Burden of Disease and Gene Expression Omnibus Datasets Jiaxi Zhang, Zhibin Liu, Ke Huang, Junkoo Yi, Myoung Ok Kim J. Cancer 2026; 17(6): 1125-1133. doi:10.7150/jca.134528 Full text PDF

Research Paper CellVizio^® System for Mesothorax Lymphadenopathy Rapid on Site, 18G needle: Pros and Cons Paul Zarogoulidis, Wolfgang Hofenforst-Schwidt, Haidong Huang, Stavros Tryfon, Yifei Zhang, Xiaping Shen, Guoren Ma, Kyriakos Amarantidis, Elena Maragouli, Vasilis Papadopoulos, Eleni-Isidora Perdikouri, Vagelis Voulgaris, Lutz Freitag, Chrysoula Margioula-Siarkou, Theodora Tsiouda, Paschalis Ntolios, Stamatis Petousis, Konstantina Triantafylopoulou, Kosmas Tsakiridis, Nikolaos Courcoutsakis, Sofia Baka, Dimitris Baloukas, Paschalis Steiropoulos, Bojan Zaric, Xiaping Shen J. Cancer 2026; 17(6): 1117-1124. doi:10.7150/jca.136122 Full text PDF

Review miR-150-5p at the Interface of Cancer Biology and Immune Regulation: Dual Roles, Mechanisms, and Therapeutic Opportunities Iris Lin, Pardis Shirkani, Cathie Garnis J. Cancer 2026; 17(6): 1105-1116. doi:10.7150/jca.119966 Full text PDF

Research Paper Vemurafenib Induces Apoptosis via JNK Activation and AKT Inhibition in Hepatocellular Carcinoma Yu Rim Cho, Ke Huang, Zhibin Liu, Hyeonjin Kim, Chae Yeon Kim, Lei Ma, Nangwon Yee, Chae Rim Kim, Geun Hye Park, Jiaxi Zhang, Zae Young Ryoo, Sung Hyun Kim, Myoung Ok Kim J. Cancer 2026; 17(5): 1094-1104. doi:10.7150/jca.130097 Full text PDF PubMed PMC

Research Paper Serum Thyroid Biomarkers for Diagnosing Malignant Thyroid Nodules: A Machine Learning Approach with External and Causal Validation Qingling Gu, Faling Xue, Xiaojing Shi, Zhuoling Zheng, Wenqing Wang, Zhuolin Yang, Yiyu Zhang, Wenqi Huang, Min Huang, Zhongxing Wang, Jiali Li J. Cancer 2026; 17(5): 1082-1093. doi:10.7150/jca.131422 Full text PDF PubMed PMC

Research Paper MRI-Based Habitat Radiomics for Differentiating Early-Stage Endometrial Carcinoma from Submucous Leiomyoma: A Multicenter Validation Study Hao Tian, Anqi Yan, Lei Cao, Ziyi Pan, Yuyan Guo, Bo Shen, Jing Wang, Jingxuan Jiang J. Cancer 2026; 17(5): 1073-1081. doi:10.7150/jca.129931 Full text PDF PubMed PMC

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Issue 5; 2026

Indexed in PubMed and SCI expanded; full texts in Europe PMC. ...

MRI-Based Habitat Radiomics for Differentiating Early-Stage Endometrial Carcinoma from Submucous Leiomyoma: A Multicenter Validation Study

Objective: This study aimed to investigate the utility of magnetic resonance imaging (MRI)-based habitat radiomics for preoperatively distinguishing early-stage endometrial carcinoma (EC) from submucous leiomyoma (SML). Materials and Methods: A retrospective study was conducted on uterine lesions patients who underwent MRI from three hospitals. The k-means clustering algorithm was applied to segment the MRI into distinct habitats based on T1-weighted ...

Vemurafenib Induces Apoptosis via JNK Activation and AKT Inhibition in Hepatocellular Carcinoma

Background: Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and remains one of the leading contributors to cancer-related mortality worldwide, primarily due to the disease's therapeutic resistance and marked tumor heterogeneity. Among the molecular mechanisms implicated in HCC progression, the dysregulation of the JNK and PI3K/AKT signaling pathways plays a critical role in tumor initiation, cell proliferation, and cell ...