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Review Development of nasopharyngeal carcinoma target delineation: from two-dimensional radiotherapy to adaptive precision radiotherapy Xiaojing Yang, Lijun Liu, Huicai Zhang, Hanru Ren, Jie Fu J. Cancer 2026; 17(6): 1179-1186. doi:10.7150/jca.125480 Full text PDF


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Research Paper Dehydroleucodine Induces ROS-Mediated Mitochondrial Apoptosis and G2/M Cell Cycle Arrest in Oral Squamous Cell Carcinoma Johnathon Lee, Tsung-Ming Chang, Chia-Jung Lee, Ju-Fang Liu, Hsin-Hua Chou J. Cancer 2026; 17(6): 1165-1178. doi:10.7150/jca.127924 Full text PDF


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Review The Emerging Role of CACNA1E in Cancer: Molecular Mechanisms and Therapeutic Implications Wei Hou J. Cancer 2026; 17(6): 1155-1164. doi:10.7150/jca.133409 Full text PDF


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Research Paper Development and Validation of an m6A-Derived Prognostic Signature in Lung Adenocarcinoma Zheng Shao, YongLi Situ, Bairu Lai, Ying Xu, Jv Chen, Li Deng, QinYing Xu, Meng Liang, Zhu Liang, ZhanQiang Xie J. Cancer 2026; 17(6): 1134-1154. doi:10.7150/jca.134792 Full text PDF


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Research Paper Epidemiological Trends and Shared Molecular Signatures of Pancreatic Ductal Adenocarcinoma and Diabetes: An Integrative Analysis Based on Global Burden of Disease and Gene Expression Omnibus Datasets Jiaxi Zhang, Zhibin Liu, Ke Huang, Junkoo Yi, Myoung Ok Kim J. Cancer 2026; 17(6): 1125-1133. doi:10.7150/jca.134528 Full text PDF


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Research Paper CellVizio® System for Mesothorax Lymphadenopathy Rapid on Site, 18G needle: Pros and Cons Paul Zarogoulidis, Wolfgang Hofenforst-Schwidt, Haidong Huang, Stavros Tryfon, Yifei Zhang, Xiaping Shen, Guoren Ma, Kyriakos Amarantidis, Elena Maragouli, Vasilis Papadopoulos, Eleni-Isidora Perdikouri, Vagelis Voulgaris, Lutz Freitag, Chrysoula Margioula-Siarkou, Theodora Tsiouda, Paschalis Ntolios, Stamatis Petousis, Konstantina Triantafylopoulou, Kosmas Tsakiridis, Nikolaos Courcoutsakis, Sofia Baka, Dimitris Baloukas, Paschalis Steiropoulos, Bojan Zaric, Xiaping Shen J. Cancer 2026; 17(6): 1117-1124. doi:10.7150/jca.136122 Full text PDF

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Epidemiological Trends and Shared Molecular Signatures of Pancreatic Ductal Adenocarcinoma and Diabetes: An Integrative Analysis Based on Global Burden of Disease and Gene Expression Omnibus Datasets

Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies worldwide, and diabetes mellitus has been recognized as both a risk factor for and a potential consequence of PDAC. However, the epidemiological trends and shared molecular mechanisms underlying this association are not completely understood. Methods: We conducted an integrative analysis combining population-level epidemiological data and transcriptomic datasets. ...


Development and Validation of an m6A-Derived Prognostic Signature in Lung Adenocarcinoma

Background: Lung adenocarcinoma (LUAD) exhibits extensive molecular heterogeneity and poor prognosis, necessitating novel epigenetic biomarkers. N6-methyladenosine (m6A) modification, a pivotal epigenetic regulator of RNA, is frequently dysregulated in LUAD, yet its systematic roles in clinical prognosis and the tumor microenvironment (TME) remain poorly elucidated. Methods: Transcriptomic profiles and clinical data from large-scale cohorts were integrated ...

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