J Cancer 2018; 9(2):375-388. doi:10.7150/jca.21044

Review

miR-149 in Human Cancer: A Systemic Review

Yunjie He1*, Dandan Yu2*, Lingping Zhu1*, Shanliang Zhong2, Jianhua Zhao2, Jinhai Tang1,3✉

1. The First Clinical School of Nanjing Medical University, Nanjing 210029, P.R. China;
2. Center of Clinical Laboratory, Nanjing Medical University Affiliated Cancer Hospital Cancer Institute of Jiangsu Province, Baiziting 42, Nanjing 210009, P.R. China;
3. Department of General Surgery, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, P.R. China.
* Equal contributors

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that regulate post-transcriptional gene expression via binding to the 3'-untranslated region (3'-UTR) of targeted mRNAs. They are reported to play important roles in tumorigenesis and progression of various cancers. Among them, miR-149 was confirmed to be aberrantly regulated in various tumors. In this review, we provide a complex overview of miR-149, particularly summarize the critical roles of it in cancers and expect to lay the foundation for future works on this important microRNA.

Keywords: miRNA, miR-149, cancer.

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How to cite this article:
He Y, Yu D, Zhu L, Zhong S, Zhao J, Tang J. miR-149 in Human Cancer: A Systemic Review. J Cancer 2018; 9(2):375-388. doi:10.7150/jca.21044. Available from http://www.jcancer.org/v09p0375.htm