J Cancer 2017; 8(12):2238-2246. doi:10.7150/jca.19295

Review

Central Role of CEMIP in Tumorigenesis and Its Potential as Therapeutic Target

Li Li1✉, Lin-Hai Yan2✉, Shwetha Manoj3, Ying Li4, Lu Lu5

1. Department of Pharmacy, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi Zhuang Autonomous Region, People's Republic of China
2. Department of Gastrointestinal Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, People's Republic of China
3. Quality Assurance Department, Bristol Laboratories Limited, 5 Traynor Way, Whitehouse Business Park, Peterlee, County Durham, SR8 2RU, United Kingdom
4. Department of Pharmacy, Guangxi Bone Hospital, Nanning, 530000, Guangxi Zhuang Autonomous Region, People's Republic of China
5. Department of Research, Nanning Children Rehabilitation Center, Nanning, 530003, Guangxi Zhuang Autonomous Region, People's Republic of China

Abstract

CEMIP (KIAA1199) was identified as migratory indicator protein which had been crudely studied in the last decade. Firstly its mutation site was reported to cause hearing loss due to the folding change of protein structure, meanwhile the over-expression of CEMIP referred to dreadful invasion and uncontrolled proliferation of tumor with distant metastasis, dedifferentiation, and limited survival opportunity of patients. Especially, over-expressed CEMIP also protected malignant tumor from strict microenvironment in hypoxia, low glucose and cracked barrier, leading to enhanced adaptability of tumor by stimulating the Wnt, EGFR, FGFR pathway. Here, we intend to elaborate the clinical function and dysregulation of CEMIP under the tumorous circumstance since CEMIP plays an important role in cytokine pathway and its over-expression in tumors provide a novel target for individual therapy. Targeting CEMIP would thereby dysregulate the cytokine pathway which would in turn, decide the growth and death of the vicious tumour cells.

Keywords: CEMIP/KIAA1199, Cancer, Cytokine Signaling pathway, Hyaluronic acid.

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How to cite this article:
Li L, Yan LH, Manoj S, Li Y, Lu L. Central Role of CEMIP in Tumorigenesis and Its Potential as Therapeutic Target. J Cancer 2017; 8(12):2238-2246. doi:10.7150/jca.19295. Available from http://www.jcancer.org/v08p2238.htm