J Cancer 2015; 6(10):990-995. doi:10.7150/jca.11650

Research Paper

Increased Expression of Eps15 Homology Domain 1 is Associated with Poor Prognosis in Resected Small Cell Lung Cancer

Qingwei Meng 1†, Weiling Sun2†, Man Li2†, Yanbin Zhao1, Xuesong Chen1, Lichun Sun1, Li Cai1 ✉

1. The Fourth Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
2. The Department of Endoscopy, Harbin Medical University Cancer Hospital, Harbin, China
† These authors contribute equally to this work.

Abstract

One of the great challenges of small cell lung cancer (SCLC) treatment is identifying patients at high risk for recurrence after surgical resection and chemotherapy. We examined Eps15 homology domain 1 (EHD1) protein expression in paraffin sections of 85 resected SCLC tissues, metastatic lymph nodes and normal bronchial epithelial tissues using immunohistochemistry to study the correlation between EHD1 expression and patient clinicopathological features. Within these variables, disease free survival (DFS) analyzed by the log-rank test was constructed using the multivariate Cox proportional hazards regression model and Kaplan-Meier analysis. Immunohistochemistry results showed that EHD1 protein was significantly increased in SCLC tissues compared with normal tissues (P < 0.001). Moreover, EHD1 expression was positively correlated with tumor size (P = 0.019). Multivariate Cox proportional hazards model analysis showed that EHD1 expression (P = 0.047; HR, 1.869; 95% CI, 1.008-3.466) and American Joint Committee on Cancer (AJCC) status (P < 0.001; HR, 1.412; 95% CI, 1.165-1.711) were independent prognostic indicators of DFS. In conclusion, these data demonstrated a remarkable correlation between the cytoplasmic expression of EHD1 protein and adverse prognosis in patients receiving early-stage cisplatin treatment for resected SCLC.

Keywords: Eps15 homology domain 1, Disease-free survival, Small cell lung cancer, Survival, Immunohistochemistry

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How to cite this article:
Meng Q, Sun W, Li M, Zhao Y, Chen X, Sun L, Cai L. Increased Expression of Eps15 Homology Domain 1 is Associated with Poor Prognosis in Resected Small Cell Lung Cancer. J Cancer 2015; 6(10):990-995. doi:10.7150/jca.11650. Available from http://www.jcancer.org/v06p0990.htm