Glucose metabolism reprogramming in gynecologic malignant tumors

Ma, Jianhong; Yao, Zhiqiang; Ma, Liangjian; Zhu, Qinyin; Zhang, Jiajia; Li, Ling; Liu, Chang

doi:10.7150/jca.91131

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Journal of Genomics

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J Cancer 2024; 15(9):2627-2645. doi:10.7150/jca.91131 This issue Cite

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Glucose metabolism reprogramming in gynecologic malignant tumors

Jianhong Ma^1*, Zhiqiang Yao^2*, Liangjian Ma¹, Qinyin Zhu¹, Jiajia Zhang³, Ling Li¹, Chang Liu^2,4✉

1. The First Clinical Medical College of Lanzhou University, Lanzhou, 730000, China.
2. Department of Obstetrics and Gynecology, the First Hospital of Lanzhou University, Lanzhou, 730000, China.
3. Department of Child Health, the First Hospital of Lanzhou University, Lanzhou, 730000, China.
4. Key Laboratory of Gynecological Oncology of Gansu Province, Lanzhou, 730000, China.
^* These authors have contributed equally to this work and share first authorship.

Citation:

Ma J, Yao Z, Ma L, Zhu Q, Zhang J, Li L, Liu C. Glucose metabolism reprogramming in gynecologic malignant tumors. J Cancer 2024; 15(9):2627-2645. doi:10.7150/jca.91131. https://www.jcancer.org/v15p2627.htm

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Abstract

The incidence and mortality of gynecological tumors are progressively increasing due to factors such as obesity, viral infection, unhealthy habits, as well as social and economic pressures. Consequently, it has emerged as a significant threat to women's health. Numerous studies have revealed the remarkable metabolic activity of tumor cells in glycolysis and its ability to influence malignant biological behavior through specific mechanisms. Therefore, it is crucial for patients and gynecologists to comprehend the role of glycolytic proteins, regulatory molecules, and signaling pathways in tumorigenesis, progression, and treatment. This article aims to review the correlation between abnormal glucose metabolism and gynecologic tumors including cervical cancer (CC), endometrial carcinoma (EC), and ovarian cancer (OC). The findings from this research will provide valuable scientific insights for early screening, timely diagnosis and treatment interventions while also aiding in the prevention of recurrence among individuals with gynecological tumors.

Keywords: Warburg effect, aerobic glycolysis, cervical cancer, endometrial carcinoma, ovarian cancer, pathological mechanism

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APA

Ma, J., Yao, Z., Ma, L., Zhu, Q., Zhang, J., Li, L., Liu, C. (2024). Glucose metabolism reprogramming in gynecologic malignant tumors. Journal of Cancer, 15(9), 2627-2645. https://doi.org/10.7150/jca.91131.

ACS

Ma, J.; Yao, Z.; Ma, L.; Zhu, Q.; Zhang, J.; Li, L.; Liu, C. Glucose metabolism reprogramming in gynecologic malignant tumors. J. Cancer 2024, 15 (9), 2627-2645. DOI: 10.7150/jca.91131.

NLM

CSE

Ma J, Yao Z, Ma L, Zhu Q, Zhang J, Li L, Liu C. 2024. Glucose metabolism reprogramming in gynecologic malignant tumors. J Cancer. 15(9):2627-2645.

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