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J Cancer 2024; 15(9):2613-2626. doi:10.7150/jca.93531 This issue Cite

Review

tsRNA: A Promising Biomarker in Breast Cancer

Ting Huang¹, Yuexin Zhao², Guoqin Jiang¹, Zhixue Yang^1✉

1. Department of Thyroid and Breast Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
2. Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.

✉ Corresponding author: Zhixue Yang, E-mail address: yzx0495edu.cn.

Abstract

tRNA-derived small RNAs (tsRNAs) are a novel class of non-coding small RNAs, generated from specific cleavage sites of tRNA or pre-tRNA. tsRNAs can directly participate in RNA silencing, transcription, translation, and other processes. Their dysregulation is closely related to the occurrence and development of various cancers. Breast cancer is one of the most common and fastest-growing malignant tumors in humans. tsRNAs have been found to be dysregulated in breast cancer, serving as a new target for exploring the pathogenesis of breast cancer. They are also considered new tumor markers, providing a basis for diagnosis and treatment. This article reviews the generation, classification, mechanism of action, function of tsRNAs, and their biological effects and related mechanisms in breast cancer, in the hope of providing a new direction for the diagnosis and treatment of breast cancer.

Keywords: Breast Cancer, tRF, tiRNA, tsRNA, Biomarker, Liquid Biopsy

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