J Cancer
2023; 14(2):250-261.
doi:10.7150/jca.79967 This issueCite
Research Paper
Identification of a CircRNA-miRNA-mRNA Network and Integrated Analysis of Immune Infiltration in Oral Squamous Cell Carcinoma
Dehua Hu1#, Yufeng Cai1#, Lan He2, Hao Jiang1✉
1. Department of Biomedical Informatics, School of Life Sciences, Central South University, Changsha, Hunan 410078, China. 2. College of Biology, Hunan University, Changsha, Hunan 410078, China. #Dehua Hu and Yufeng Cai contributed equally to this article and share first authorship.
✉ Corresponding author: Hao Jiang, 172# Tongzipo Road, School of Life Sciences, Central South University, Changsha, Hunan 410011, People's Republic of China. Tel: +86-13671769729. Email: jianghao1209edu.cn.
Citation:
Hu D, Cai Y, He L, Jiang H. Identification of a CircRNA-miRNA-mRNA Network and Integrated Analysis of Immune Infiltration in Oral Squamous Cell Carcinoma. J Cancer 2023; 14(2):250-261. doi:10.7150/jca.79967. https://www.jcancer.org/v14p0250.htm
Oral squamous cell carcinoma (OSCC) is a highly invasive type of head and neck cancer. Circular RNA (circRNA) acts as a competing endogenous RNA (ceRNA) and involves in pathogenesis of many diseases. However, the circRNA-miRNA-mRNA network and relationship between ceRNA and immune infiltration in OSCC remain unknown. In this study, we established a ceRNA network, including 89 circRNAs, 43 miRNAs and 223 mRNAs, and found that 233 genes are mainly related to malignant signalling pathways (including "Integrin family cell surface interactions" and "Epithelial-to-mesenchymal transition" pathways) and five potential biomarkers (SLC20A1, PITX2, hsa-mir-135b, hsa-mir-377 and hsa-let-7c). Meanwhile, we established a prognostic model based on clinical risk, and revealed the relationship between immune infiltrating cells and biomarkers in OSCC. Taken together, our study is helpful to reveal the pathogenesis of oral squamous cell carcinoma.
Hu, D., Cai, Y., He, L., Jiang, H. (2023). Identification of a CircRNA-miRNA-mRNA Network and Integrated Analysis of Immune Infiltration in Oral Squamous Cell Carcinoma. Journal of Cancer, 14(2), 250-261. https://doi.org/10.7150/jca.79967.
ACS
Hu, D.; Cai, Y.; He, L.; Jiang, H. Identification of a CircRNA-miRNA-mRNA Network and Integrated Analysis of Immune Infiltration in Oral Squamous Cell Carcinoma. J. Cancer 2023, 14 (2), 250-261. DOI: 10.7150/jca.79967.
NLM
Hu D, Cai Y, He L, Jiang H. Identification of a CircRNA-miRNA-mRNA Network and Integrated Analysis of Immune Infiltration in Oral Squamous Cell Carcinoma. J Cancer 2023; 14(2):250-261. doi:10.7150/jca.79967. https://www.jcancer.org/v14p0250.htm
CSE
Hu D, Cai Y, He L, Jiang H. 2023. Identification of a CircRNA-miRNA-mRNA Network and Integrated Analysis of Immune Infiltration in Oral Squamous Cell Carcinoma. J Cancer. 14(2):250-261.
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