J Cancer
2021; 12(23):7158-7166.
doi:10.7150/jca.61567 This issueCite
Research Paper
GOLM1 Drives Colorectal Cancer Metastasis by Regulating Myeloid-derived Suppressor Cells
Yunzhi Dang✉, Jiao Yu, Shuhong Zhao, Long Jin, Ximing Cao, Qing Wang
Department of Radiation Oncology, Shaanxi Provincial People's Hospital, Xi'an, 710086, China.
✉ Corresponding author: Dr. Yunzhi Dang, Department of Radiation Oncology, Shaanxi Provincial People's Hospital, Xi'an 710086, China; Tel: +86-29-8525 2140; Email: dangyunzhiedu.cn
Citation:
Dang Y, Yu J, Zhao S, Jin L, Cao X, Wang Q. GOLM1 Drives Colorectal Cancer Metastasis by Regulating Myeloid-derived Suppressor Cells. J Cancer 2021; 12(23):7158-7166. doi:10.7150/jca.61567. https://www.jcancer.org/v12p7158.htm
Colorectal cancer (CRC) is the most common digestive neoplasms worldwide, metastasis and recurrence still account for the leading cause for the high mortality rate, but the exact mechanisms remain unclear. More and more evidence has indicated that the deregulation of GOLM1 plays a crucial role in cancer progression. Here, we reported a novel role of GOLM1 in promoting CRC metastasis. In this study, the expression of GOLM1 was detected in human CRC cohort. The function of GOLM1 in CRC metastasis was analyzed by in vivo cecum orthotopic model. We found that the expression of GOLM1 was significantly increased in CRC tissues than adjacent nontumor. Overexpression GOLM1 can promote CRC immune escape and metastasis by recruiting of myeloid-derived suppressor cells (MDSCs) at the same time. PF-04136309, a small molecule and specific inhibitor of CCR2 can largely suppressed GOLM1-mediated CRC metastasis. These results suggest that GOLM1 can promote CRC metastasis and is a prognostic biomarker in human CRC.
Dang, Y., Yu, J., Zhao, S., Jin, L., Cao, X., Wang, Q. (2021). GOLM1 Drives Colorectal Cancer Metastasis by Regulating Myeloid-derived Suppressor Cells. Journal of Cancer, 12(23), 7158-7166. https://doi.org/10.7150/jca.61567.
ACS
Dang, Y.; Yu, J.; Zhao, S.; Jin, L.; Cao, X.; Wang, Q. GOLM1 Drives Colorectal Cancer Metastasis by Regulating Myeloid-derived Suppressor Cells. J. Cancer 2021, 12 (23), 7158-7166. DOI: 10.7150/jca.61567.
NLM
Dang Y, Yu J, Zhao S, Jin L, Cao X, Wang Q. GOLM1 Drives Colorectal Cancer Metastasis by Regulating Myeloid-derived Suppressor Cells. J Cancer 2021; 12(23):7158-7166. doi:10.7150/jca.61567. https://www.jcancer.org/v12p7158.htm
CSE
Dang Y, Yu J, Zhao S, Jin L, Cao X, Wang Q. 2021. GOLM1 Drives Colorectal Cancer Metastasis by Regulating Myeloid-derived Suppressor Cells. J Cancer. 12(23):7158-7166.
This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.