J Cancer 2019; 10(19):4633-4638. doi:10.7150/jca.35009

Research Paper

Wnt3a protein overexpression predicts worse overall survival in laryngeal squamous cell carcinoma

Diekuo Zhang1,2, Guo Li1,2, Xiyu Chen1,2, Qiancheng Jing1,2,4, Chao Liu1,2, Shanhong Lu1,2, Donghai Huang1,2, Yunyun Wang1,2, Pingqing Tan3, Jie Chen3, Xin Zhang1,2, Yuanzheng Qiu1,2, Yong Liu1,2✉

1. Department of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China.
2. Otolaryngology Major Disease Research, Key Laboratory of Hunan Province, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China.
3. Department of Head and Neck Surgery, Hunan Cancer Hospital, The Affiliated Tumor Hospital of Xiangya Medical School, Central South University, 283 Tongzipo Road, Changsha, Hunan 410013, People's Republic of China.
4. Department of Otolaryngology, Head and Neck Surgery, Changsha Central Hospital, 161 Shaoshan Road, Changsha, Hunan 410004, People's Republic of China.

Abstract

As a classical ligand in the canonical Wnt/β-catenin signaling pathway, the role of Wnt3a in laryngeal squamous cell carcinoma (LSCC) remains unclear. Therefore, the expression pattern of the Wnt3a protein in 222 primary LSCC, and 19 corresponding adjacent non-carcinoma specimens, was detected by immunohistochemistry and further correlated with clinicopathological parameters. The results showed that LSCC tissue expressed higher levels of the Wnt3a protein when compared to the corresponding adjacent non-cancerous tissues. High expression of Wnt3a was closely related to histological grade (P = 0.031), clinical stage (I+II / III+IV; P = 0.004), and lymph node metastasis (P = 0.03). Kaplan-Meier analysis evidenced that a worse overall survival (OS) was correlated to the group with high Wnt3a expression (P = 0.003). When stratified survival analyses were performed, patients with lymph node metastasis/advanced clinical stages and high Wnt3a expression had worse OS rates than patients with other features (P < 0.001). Finally, multivariate analysis showed that Wnt3a expression was an independent prognosis factor for LSCC patients. The current findings suggest that Wnt3a is tightly related to the LSCC progression and could serve as a valuable clinic biomarker for LSCC patients.

Keywords: Laryngeal squamous cell carcinoma, Wnt3a, Metastasis, prognosis

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How to cite this article:
Zhang D, Li G, Chen X, Jing Q, Liu C, Lu S, Huang D, Wang Y, Tan P, Chen J, Zhang X, Qiu Y, Liu Y. Wnt3a protein overexpression predicts worse overall survival in laryngeal squamous cell carcinoma. J Cancer 2019; 10(19):4633-4638. doi:10.7150/jca.35009. Available from http://www.jcancer.org/v10p4633.htm