J Cancer 2019; 10(19):4574-4587. doi:10.7150/jca.21780

Review

Cellular Interactions in the Tumor Microenvironment: The Role of Secretome

Bianca Rodrigues da Cunha1,2*, Célia Domingos3,4*, Ana Carolina Buzzo Stefanini1,2, Tiago Henrique1, Giovana Mussi Polachini1, Pedro Castelo-Branco3,4,5, Eloiza Helena Tajara1,2✉

1. Department of Molecular Biology, School of Medicine of São José do Rio Preto/FAMERP, São José do Rio Preto, SP, Brazil.
2. Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo, SP, Brazil.
3. Department of Biomedical Sciences and Medicine, University of Algarve, Portugal.
4. Centre for Biomedical Research (CBMR), University of Algarve, Faro, Portugal.
5. Algarve Biomedical Center, Gambelas, Faro, Portugal.
*BRC and CD contributed equally to this work.

Abstract

Over the past years, it has become evident that cancer initiation and progression depends on several components of the tumor microenvironment, including inflammatory and immune cells, fibroblasts, endothelial cells, adipocytes, and extracellular matrix. These components of the tumor microenvironment and the neoplastic cells interact with each other providing pro and antitumor signals. The tumor-stroma communication occurs directly between cells or via a variety of molecules secreted, such as growth factors, cytokines, chemokines and microRNAs. This secretome, which derives not only from tumor cells but also from cancer-associated stromal cells, is an important source of key regulators of the tumorigenic process. Their screening and characterization could provide useful biomarkers to improve cancer diagnosis, prognosis, and monitoring of treatment responses.

Keywords: Cancer, Microenvironment, Secretome.

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How to cite this article:
da Cunha BR, Domingos C, Stefanini ACB, Henrique T, Polachini GM, Castelo-Branco P, Tajara EH. Cellular Interactions in the Tumor Microenvironment: The Role of Secretome. J Cancer 2019; 10(19):4574-4587. doi:10.7150/jca.21780. Available from http://www.jcancer.org/v10p4574.htm