Unravel the molecular mechanism of XBP1 in regulating the biology of cancer cells

Shi, Weimei; Chen, Zhixi; Li, Linfu; Liu, Hai; Zhang, Rui; Cheng, Qilai; Xu, Daohua; Wu, Longhuo

doi:10.7150/jca.29421

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International Journal of Medical Sciences

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Journal of Genomics

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J Cancer 2019; 10(9):2035-2046. doi:10.7150/jca.29421 This issue Cite

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Unravel the molecular mechanism of XBP1 in regulating the biology of cancer cells

Weimei Shi^1*, Zhixi Chen^1*, Linfu Li^1*, Hai Liu¹, Rui Zhang¹, Qilai Cheng¹, Daohua Xu^2✉, Longhuo Wu^1✉

1. College of Pharmacy, Gannan Medical University, Ganzhou China, 341000
2. Department of Pharmacology, Guangdong Medical University, Dongguan China, 523808
*These authors contributed equally to this study

Citation:

Shi W, Chen Z, Li L, Liu H, Zhang R, Cheng Q, Xu D, Wu L. Unravel the molecular mechanism of XBP1 in regulating the biology of cancer cells. J Cancer 2019; 10(9):2035-2046. doi:10.7150/jca.29421. https://www.jcancer.org/v10p2035.htm

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Abstract

Cancer cells are usually exposed to stressful environments, such as hypoxia, nutrient deprivation, and other metabolic dysfunctional regulation, leading to continuous endoplasmic reticulum (ER) stress. As the most conserved branch among the three un-folded protein response (UPR) pathways, Inositol-requiring enzyme 1α (IRE1α)-X-box-binding protein 1 (XBP1) signaling has been implicated in cancer development and progression. Active XBP1 with transactivation domain functions as a transcription factor to regulate the expression of downstream target genes, including many oncogenic factors. The regulatory activity of XBP1 in cell proliferation, apoptosis, metastasis, and drug resistance promotes cell survival, leading to tumorigenesis and tumor progression. In addition, the XBP1 peptides-based vaccination and/or combination with immune-modulatory drug administration have been developed for effective management for several cancers. Potentially, XBP1 is the biomarker of cancer development and progression and the strategy for clinical cancer management.

Keywords: XBP1, cancer cells, UPR, tumorigenesis, metastasis, drug resistance

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APA

Shi, W., Chen, Z., Li, L., Liu, H., Zhang, R., Cheng, Q., Xu, D., Wu, L. (2019). Unravel the molecular mechanism of XBP1 in regulating the biology of cancer cells. Journal of Cancer, 10(9), 2035-2046. https://doi.org/10.7150/jca.29421.

ACS

Shi, W.; Chen, Z.; Li, L.; Liu, H.; Zhang, R.; Cheng, Q.; Xu, D.; Wu, L. Unravel the molecular mechanism of XBP1 in regulating the biology of cancer cells. J. Cancer 2019, 10 (9), 2035-2046. DOI: 10.7150/jca.29421.

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CSE

Shi W, Chen Z, Li L, Liu H, Zhang R, Cheng Q, Xu D, Wu L. 2019. Unravel the molecular mechanism of XBP1 in regulating the biology of cancer cells. J Cancer. 10(9):2035-2046.

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