J Cancer 2019; 10(6):1358-1369. doi:10.7150/jca.28394

Review

Nanotechnology in metastatic cancer treatment: Current Achievements and Future Research Trends

Diana Gonciar1,3,*, Teodora Mocan2,3,*, Cristian Tudor Matea1,3,*, Claudiu Zdrehus1,3,*, Ofelia Mosteanu1,3,*, Lucian Mocan1,3,*,✉, Teodora Pop3,*

1. Third Surgery Clinic, “Iuliu Hatieganu” University of Medicine and Pharmacy Cluj-Napoca, Romania
2. Physiology Department, “Iuliu Hatieganu” University of Medicine and Pharmacy Cluj-Napoca, Romania
3. Nanomedicine Department, Regional Institute of Gastroenterology and Hepatology “Prof.Dr. Octavian Fodor” Cluj-Napoca , Romania.
*All authors have contributed equally to present work.

Abstract

The systemic spread of malignant cells from a primary site, a process termed metastasis represents a global challenge in cancer treatment. There is a real need to develop novel therapy strategies and nanomedicine may have remarkable and valuable contribution through specific and selective delivery of chemotherapeutic agents, through its intrinsic cytotoxic activity or through imaging applications, appealing also in the context of cancer personalized therapy. This review is focused on the applications of nanoparticles in the treatment of metastatic cancer, particularly on the possible effect on cell stabilization, growth inhibition, eventual interaction with adhesion molecules and antiangiogenic effect.

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How to cite this article:
Gonciar D, Mocan T, Matea CT, Zdrehus C, Mosteanu O, Mocan L, Pop T. Nanotechnology in metastatic cancer treatment: Current Achievements and Future Research Trends. J Cancer 2019; 10(6):1358-1369. doi:10.7150/jca.28394. Available from http://www.jcancer.org/v10p1358.htm