J Cancer 2018; 9(23):4391-4397. doi:10.7150/jca.26437

Research Paper

Oncolytic Adenovirus Harboring Interleukin-24 Improves Chemotherapy for Advanced Prostate Cancer

Li-jun Mao1*, Meng Ding1*, Kai Xu1*, Jun Pan1, Haiyuan Yu1, Chunhua Yang1,2✉

1. Department of Urinary Surgery, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, China.
2. Radiotherapy Department, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, China.
*Equal contributors.

Abstract

Purpose: Oncolytic adenoviruses emerge as new agents for cancer therapy. This study aimed to investigate the synergistic anti-tumor activity of oncolytic adenovirus armed with IL-24 (ZD55-IL-24) and docetaxel (DTX) on advanced prostate cancer in vitro and in vivo.

Methods: DU145 prostate cancer cells or nude mice xenografted with DU145 prostate cancer cells were treated by ZD55-IL-24 and DTX alone or in combination.

Results: DTX did not affect ZD55-IL-24 replication and IL-24 expression in DU145 cells. In vitro, the combination of ZD55-IL-24 and DTX showed synergistic inhibitory effects on prostate cancer cell viability and invasion. In vivo, ZD55-IL-24 and DTX synergistically inhibited the growth and activated the apoptosis of DU145 xenografts, accompanied by significantly decreased PARP-1 levels and increased caspase-3 and caspase-8 levels as well as decreased CD31 expression.

Conclusion: We reported the synergistic anti-tumor efficacy of ZD55-IL-24 and DTX on prostate cancer. Our results suggest that chemotherapy combined with oncolytic adenovirus mediated gene therapy is a promising strategy for the treatment of advanced prostate cancer.

Keywords: docetaxel, prostate cancer, IL-24, Oncolytic adenovirus

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How to cite this article:
Mao Lj, Ding M, Xu K, Pan J, Yu H, Yang C. Oncolytic Adenovirus Harboring Interleukin-24 Improves Chemotherapy for Advanced Prostate Cancer. J Cancer 2018; 9(23):4391-4397. doi:10.7150/jca.26437. Available from http://www.jcancer.org/v09p4391.htm