J Cancer 2018; 9(21):3950-3961. doi:10.7150/jca.25967

Research Paper

CDK5 Functions as a Tumor Promoter in Human Lung Cancer

Jie Zeng1#, Shuanshuan Xie1#, Yang Liu1, Changxing Shen1, Xiaolian Song1, Guo-Lei Zhou2,3, Changhui Wang1✉

1. Department of Respiratory Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, PR China;
2. Department of Biological Sciences, Arkansas State University, State University, AR 72467, USA;
3. Molecular Biosciences Program, Arkansas State University, State University, AR 72467, USA.
# These authors have contributed equally to this work.

Abstract

Cyclin-dependent kinase 5 (CDK5), an atypical member of the cyclin-dependent kinase family, plays an important role in the nervous system. Recent studies have shown that CDK5 is also associated with tumors. However, few studies have been done to investigate the mechanism underlying the connection between CDK5 and cancers. To explore the role of CDK5 in cancers by using an extensive bioinformatics data mining process. We mined the transcriptional, survival, functions and structure of CDK5 gene through databases and in vitro experiments. We found that higher CDK5 expression levels in most cancer cell lines while lower expression in liver and brain cancer cell lines. High expression of CDK5 was associated with shorter overall survival (OS) in lung cancer. In addition, high expression level of CDK5 promoted lung cancer cells proliferation and metastasis. Inhibited CDK5 decreases CAP1 phosphorylation. CDK5 may prove to be a valid target of anticancer therapies.

Keywords: CDK5, data mining, overall survival, tumor promoter, lung cancer

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How to cite this article:
Zeng J, Xie S, Liu Y, Shen C, Song X, Zhou GL, Wang C. CDK5 Functions as a Tumor Promoter in Human Lung Cancer. J Cancer 2018; 9(21):3950-3961. doi:10.7150/jca.25967. Available from http://www.jcancer.org/v09p3950.htm