J Cancer 2018; 9(16):2973-2980. doi:10.7150/jca.25506

Research Paper

Molecular analysis of gastric cancer identifies genomic markers of drug sensitivity in Asian gastric cancer

Qin Yang1,*, Chunchao Zhu2,*, Yanli Zhang1,*, Yangyang Wang2,*, Yahui Wang1, Lei Zhu1, Xiaomei Yang1, Jun Li1, Huizhen Nie1, Shuheng Jiang1, Xiaoxin Zhang1, Xiaoyan Cao1, Qing Li1, Xueli Zhang1, Guangang Tian1, Lipeng Hu1, Lili Zhu1, Gang Zhao2,✉, Zhigang Zhang1,✉

1. State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China
2. Department of Gastrointestinal Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China
* These authors contributed equally to this work

Abstract

Background: Gastric cancer (GC) is one of the leading causes of lethal malignancies worldwide, especially in Eastern Asia. Clinical responses to antitumor therapies are often limited to a subset of patients.

Methods: To uncover new biomarkers of sensitivity and resistance to cancer therapeutics, we performed ultra-deep targeted sequencing in a cohort with 72 patients (41 with chemotherapy sensitivity and 31 with chemotherapy resistance).

Results: We found that sixteen mutated cancer genes were associated with widely used agent in chemotherapy of gastric cancer. Genes identified in these study are mainly involved in activation and inactivation of cancer chemotherapeutic agents, changes of apoptosis and proliferation, drug efflux, DNA damage repair, and the tumor microenvironment.

Discussion: A novel group of chemo-sensitivity related genes provided new therapeutic strategies to overcome the development and evolution of resistance to cancer chemotherapy.

Keywords: Gastric cancer, Chemotherapy response, Mutation

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How to cite this article:
Yang Q, Zhu C, Zhang Y, Wang Y, Wang Y, Zhu L, Yang X, Li J, Nie H, Jiang S, Zhang X, Cao X, Li Q, Zhang X, Tian G, Hu L, Zhu L, Zhao G, Zhang Z. Molecular analysis of gastric cancer identifies genomic markers of drug sensitivity in Asian gastric cancer. J Cancer 2018; 9(16):2973-2980. doi:10.7150/jca.25506. Available from http://www.jcancer.org/v09p2973.htm