J Cancer 2018; 9(11):1905-1914. doi:10.7150/jca.24491

Research Paper

Risk Factors of the Recurrences of Pancreatic Solid Pseudopapillary Tumors: A Systematic Review and Meta-analysis

Hao Gao1,2,3,*, Yong Gao1,2,3,*, Lingdi Yin1,2,3,*, Guangfu Wang1,2,3, Jishu Wei1,2,3, Kuirong Jiang1,2,3, Yi Miao1,2,3✉

1. Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People's Republic of China.
2. Pancreas Institute of Nanjing Medical University, Nanjing, 210029, People's Republic of China.
3. Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People's Republic of China.
*These three authors contributed equally to this work.

Abstract

Background: Pancreatic solid pseudopapillary tumors (SPTs) are rare neoplasms with low-grade malignancy. The main treatment for them is surgical resection. However, some SPTs relapse after resection. The risk factors associated with the recurrences of resected SPTs remain controversial to date. We performed a systematic review and meta-analysis to identify the risk factors of the recurrences of pancreatic SPTs.

Materials and Methods: We searched PubMed, EMBASE, and the Cochrane Library from their inception to December 2017. Studies that focused on the risk factors of postoperative relapses of pancreatic SPTs were enrolled. Combined ORs with 95% CIs were calculated to evaluate the effects of relevant factors investigated in eligible studies. Heterogeneity among combined results was assessed by Cochran's Q test and by the degree of inconsistency (I2). Statistical analyses were performed by Review Manager (version 5.3) using random effects models.

Results: We included 10 studies, which enrolled 1091 patients. The pooled results suggested that patients with larger tumors (diameter > 5cm), lymphovascular invasion, lymph node metastasis, synchronous metastasis and positive margin were prone to suffer from the recurrences of SPTs. In addition, some factors like gender, location of tumors, perineural invasion, calcification and capsular invasion did not show any correlation with the relapses of resected SPTs.

Conclusion: Factors including a larger tumor size (diameter > 5cm), lymphovascular invasion, lymph node metastasis, synchronous metastasis and positive margin may increase the risk of recurrences of resected pancreatic SPTs. All SPTs should be excised and patients with high-risk features should undergo a long-term follow-up.

Keywords: pancreatic solid pseudopapillary tumors, recurrence, risk factors

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How to cite this article:
Gao H, Gao Y, Yin L, Wang G, Wei J, Jiang K, Miao Y. Risk Factors of the Recurrences of Pancreatic Solid Pseudopapillary Tumors: A Systematic Review and Meta-analysis. J Cancer 2018; 9(11):1905-1914. doi:10.7150/jca.24491. Available from http://www.jcancer.org/v09p1905.htm