The prognostic value of age in non-metastatic gastric cancer after gastrectomy: a retrospective study in the U.S. and China

Zhang, Jieyun; Gan, Lu; Xu, Mi-die; Huang, Mingzhu; Zhang, Xiaowei; Gong, Yiwei; Wang, Xi; Yu, Guanzhen; Guo, Weijian

doi:10.7150/jca.22085

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J Cancer 2018; 9(7):1188-1199. doi:10.7150/jca.22085 This issue Cite

Research Paper

The prognostic value of age in non-metastatic gastric cancer after gastrectomy: a retrospective study in the U.S. and China

Jieyun Zhang^1,2*, Lu Gan^3*, Mi-die Xu^2,4*, Mingzhu Huang^1,2, Xiaowei Zhang^1,2, Yiwei Gong^1,2, Xi Wang⁵, Guanzhen Yu⁶, Weijian Guo^1,2✉

1. Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China
2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China
3. Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
4. Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China
5. Department of Oncology, the 117th Hospital of PLA, 14 Lingyin Road, Hangzhou 310013, P.R. China
6. Department of Oncology, East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China
* These authors contributed equally to this work.

Citation:

Zhang J, Gan L, Xu Md, Huang M, Zhang X, Gong Y, Wang X, Yu G, Guo W. The prognostic value of age in non-metastatic gastric cancer after gastrectomy: a retrospective study in the U.S. and China. J Cancer 2018; 9(7):1188-1199. doi:10.7150/jca.22085. https://www.jcancer.org/v09p1188.htm

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Abstract

Purpose: We explored the influence of age on clinicopathologic features and survival of patients with M0 gastric cancer (GC).

Methods: 16856 GC patients from Surveillance, Epidemiology and End Results (SEER) database and 1037 GC patients from Chinese multiple centers were enrolled in the U.S. and Chinese cohort, respectively. 50-year-old was treated as cutoff age. Propensity score method was used to carry out a 1:1 paired match.

Results: In the U.S. cohort, we found that younger patients presented poor tumor behavior. However, in spite of worse outcome in stage I~IV cohort, young group showed better 3-year survival in M0 patients, especially for those who underwent a total gastrectomy. In a matched analysis, a better prognosis was still observed in younger group. The prognostic value of age was also validated in M0 GC patients with gastrectomy in Chinese cohort.

Conclusions: In spite of the worse outcome in survival curve of stage I~IV GC cohort, young patients with gastrectomy presented favorable survival in M0 subgroup. It is also applicable in China. Early diagnosis and treatment should be taken seriously in young GC patients since they often possess poorer characteristics but benefited more from gastrectomy.

Keywords: Gastric cancer, age, SEER, survival analysis, retrospective study

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APA

Zhang, J., Gan, L., Xu, M.d., Huang, M., Zhang, X., Gong, Y., Wang, X., Yu, G., Guo, W. (2018). The prognostic value of age in non-metastatic gastric cancer after gastrectomy: a retrospective study in the U.S. and China. Journal of Cancer, 9(7), 1188-1199. https://doi.org/10.7150/jca.22085.

ACS

Zhang, J.; Gan, L.; Xu, M.d.; Huang, M.; Zhang, X.; Gong, Y.; Wang, X.; Yu, G.; Guo, W. The prognostic value of age in non-metastatic gastric cancer after gastrectomy: a retrospective study in the U.S. and China. J. Cancer 2018, 9 (7), 1188-1199. DOI: 10.7150/jca.22085.

NLM

CSE

Zhang J, Gan L, Xu Md, Huang M, Zhang X, Gong Y, Wang X, Yu G, Guo W. 2018. The prognostic value of age in non-metastatic gastric cancer after gastrectomy: a retrospective study in the U.S. and China. J Cancer. 9(7):1188-1199.

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