J Cancer 2018; 9(5):901-905. doi:10.7150/jca.21511

Research Paper

Characteristics and Treatment of Brain Metastases from Esophageal Squamous Cell Carcinoma

Qiaoqiao Li1,2*, Meiling Deng1,2*, Mian Xi1,2, Yujia Zhu1,2, Yonghong Hu1,2✉

1. State Key Laboratory of Oncology in South China, Guangdong Esophageal Cancer Institute; Collaborative Innovation Center for Cancer Medicine, Guangzhou, China;
2. Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, China;
* authors contributed equally to this work.


Brain metastasis is very rare in esophageal squamous cell carcinoma (ESCC). We retrospectively analyzed 4494 patients diagnosed with ESCC between 2010 and 2015 at a single institute; 15 of these patients developed brain metastases. All 15 patients had neurologic symptoms and were diagnosed by imaging or biology. Of the 15 patients, 67% had a solitary brain lesion and 73% had lesions larger than 3 cm. After treatment of the brain lesions, including surgery (53%) or stereotactic radiotherapy with or without whole brain radiation (20%), the median progression free survival time and the 2-year overall survival rate calculated from diagnosis of brain metastasis were 14.4 months and 36%, respectively. A graded prognostic assessment (GPA) score > 2.0 was associated with significantly better overall survival. Patients with brain metastases from ESCC achieve good overall survival after appropriate treatment of the brain lesion(s); GPA score may represent a prognostic factor for treatment decision-making.

Keywords: esophageal squamous cell carcinoma, bran metastases, survival, treatment

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Li Q, Deng M, Xi M, Zhu Y, Hu Y. Characteristics and Treatment of Brain Metastases from Esophageal Squamous Cell Carcinoma. J Cancer 2018; 9(5):901-905. doi:10.7150/jca.21511. Available from http://www.jcancer.org/v09p0901.htm