J Cancer 2018; 9(2):304-309. doi:10.7150/jca.22004

Research Paper

Capn4 overexpression indicates poor prognosis of ovarian cancer patients

Ming-Fang Yang1, Yuan-Lei Lou2, Si-Sun Liu1, Shan-Shan Wang3, Chun-Hua Yin1, Xiao-Hua Cheng4✉, Ou-Ping Huang5✉

1. Department of Obstetrics and Gynecology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China;
2. Institute of Urology, Nanchang University, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China;
3. Department of Pathology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China;
4. Department of Pharmacy, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China;
5. Department of Obstetrics and Gynecology, Jiangxi Maternal and Child Health Hospital, Nanchang 330006, China.

Abstract

Recent studies have shown a close correlation between Capn4 expression and the prognosis of patients with solid tumors. This study aimed to investigate clinical role of Capn4 in ovarian cancer. The expression of Capn4 in 113 ovarian cancer and 35 non-tumor tissue samples were detected by quantitative real-time polymerase chain reaction (qRT-PCR). Capn4 expression was significantly upregulated in ovarian cancer tissues compared with non-tumor tissues (p < 0.01), and was positively correlated to FIGO stage, tumor grade and distant metastasis of ovarian cancer. Kaplan-Meier analysis indicated that patients with high Capn4 expression had shorter overall survival (HR = 1.929, 95%CI: 1.210-3.077, P= 0.006) and progress-free survival (PFS) (HR = 2.043, 95%CI: 1.276-3.271, P= 0.003). Moreover, univariate Cox regression analysis demonstrated that Capn4 overexpression was an unfavorable prognostic factor for ovarian cancer (HR = 2.819, 95%CI: 1.365-3.645, P = 0.003). After the adjustment with age, histological type and tumor size, multivariate Cox regression analysis showed that Capn4 expression level (HR = 2.157,95%CI: 1.091-3.138, P = 0.014), distant metastasis (HR = 1.576, 95%CI: 1.025-3.012, P = 0.028), tumor grade (HR = 1.408, 95%CI: 0.687-2.884, P = 0.037), and FIGO stage (HR = 1.791, 95%CI: 1.016-3.158, P=0.036) were independent poor prognostic indicators for ovarian cancer. In conclusion, Capn4 has the potential as a new prognostic marker for patients with ovarian cancer.

Keywords: ovarian cancer, Capn4, prognosis, biomarker.

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How to cite this article:
Yang MF, Lou YL, Liu SS, Wang SS, Yin CH, Cheng XH, Huang OP. Capn4 overexpression indicates poor prognosis of ovarian cancer patients. J Cancer 2018; 9(2):304-309. doi:10.7150/jca.22004. Available from http://www.jcancer.org/v09p0304.htm