J Cancer 2018; 9(2):232-238. doi:10.7150/jca.22962

Review

Interferon-γ and Colorectal Cancer: an up-to date

Christoforos Kosmidis1, Konstantinos Sapalidis1, Triantafyllia Koletsa2, Maria Kosmidou3, Christoforos Efthimiadis4, George Anthimidis4, Nikolaos Varsamis1, Nikolaos Michalopoulos1, Charilaos Koulouris1, Stefanos Atmatzidis1, Lazaros Liavas1, Titika-Marina Strati1, Georgios Koimtzis1, Alexandros Tsakalidis1, Stylianos Mantalovas1, Katerina Zarampouka2, Maria Florou1, Dimitrios E. Giannakidis1, Eleni Georgakoudi1, Sofia Baka5, Paul Zarogoulidis6✉, Yan-Gao Man7, Isaac Kesisoglou1

1. 3rd Department of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Medical School;
2. Pathology Department, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece;
3. 1st Internal Medicine Division, University Hospital of Ioannina, University of Ioaninna, Medical School;
4. Surgery Department, “Interbalkan” European Medical Center, Thessaloniki, Greece;
5. Oncology Department, “Interbalkan” European Medical Center, Thessaloniki, Greece;
6. Pulmonary - Oncology Department, “Theageneio” Anticancer Hospital, Thessaloniki, Greece;
7. Research Laboratory and International Collaboration, Bon Secours Cancer Institute, VA, USA.

Abstract

Colorectal cancer still remains the third cause of cancer death among cancer patients. Early diagnosis is crucial and they can be either endoscopic or with blood biomarkers. Endoscopic methods consist of gastroscopy and colonoscopy, however; in recent years, endoscopic ultrasound is being used. The microenvironment is very important for the successful delivery of the treatment. Several proteins and hormones play a crucial role in the efficiency of the treatment. In the current mini review we will focus on interferon-γ.

Keywords: colorectal cancer, microenvironment, interferon-γ.

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How to cite this article:
Kosmidis C, Sapalidis K, Koletsa T, Kosmidou M, Efthimiadis C, Anthimidis G, Varsamis N, Michalopoulos N, Koulouris C, Atmatzidis S, Liavas L, Strati TM, Koimtzis G, Tsakalidis A, Mantalovas S, Zarampouka K, Florou M, Giannakidis DE, Georgakoudi E, Baka S, Zarogoulidis P, Man YG, Kesisoglou I. Interferon-γ and Colorectal Cancer: an up-to date. J Cancer 2018; 9(2):232-238. doi:10.7150/jca.22962. Available from http://www.jcancer.org/v09p0232.htm