J Cancer 2017; 8(19):4155-4161. doi:10.7150/jca.21561

Research Paper

Defining Radiation-Induced Hepatic Toxicity in Hepatocellular Carcinoma Patients Treated with Stereotactic Body Radiotherapy

Jin Ho Song1,5*, Bae-Kwon Jeong2,5*, Hoon-Sik Choi1, Hojin Jeong2,5, Yun Hee Lee2,5, Hong Jun Kim3,5, Tae Hyo Kim3,5, Woon Tae Jung3,5, Ok Jae Lee3,5, Hong Seok Jang4, Byung Ock Choi4, Ki Mun Kang2,5✉

1. Department of Radiation Oncology, Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, 51472 Changwon, Korea
2. Department of Radiation Oncology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, 52727 Jinju, Korea
3. Department of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, 52727 Jinju, Korea
4. Department of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 06591 Seoul, Korea
5. Institute of Health Sciences, Gyeongsang National University, 52727 Jinju, Korea
*JHS and BKJ contributed equally to this work

Abstract

The definition and criteria of radiation-induced hepatic toxicity (RIHT) in hepatocellular carcinoma patients vary among studies. Therefore, the reported rates of RIHT differ among studies, and this causes confusion. In this study, we evaluated RIHT using several laboratory and clinical parameters, and analyzed which criterion is more correlated with RT and survival. Forty-five HCC patients treated with stereotactic body radiotherapy were included for the analysis. All patients had unresectable HCC and Child-Pugh (CP) class A or B baseline liver function. A median total dose of 45 Gy was delivered by CyberKnife in 3 fractions. For individual laboratory parameter, ≥ grade 2 toxicity development of bilirubin, albumin, or prothrombin time by Common Terminology Criteria of Adverse Effects (CTCAE) was correlated with mean liver dose and survival. However, serum transaminases had no correlation with liver mean dose and survival, and were rather affected by other local treatments. Compared to the CTCAE, the increase in the CP score of 2 points or more was better correlated with liver failure and overall survival, and it was not affected by other local treatments or tumor progression. We concluded RIHT was better defined by the change in the CP score rather than the CTCAE in patients treated by stereotactic body radiotherapy for HCC.

Keywords: Hepatocellular carcinoma, radiation therapy, stereotactic body radiotherapy, radiation-induced liver disease, Child-Pugh score

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How to cite this article:
Song JH, Jeong BK, Choi HS, Jeong H, Lee YH, Kim HJ, Kim TH, Jung WT, Lee OJ, Jang HS, Choi BO, Kang KM. Defining Radiation-Induced Hepatic Toxicity in Hepatocellular Carcinoma Patients Treated with Stereotactic Body Radiotherapy. J Cancer 2017; 8(19):4155-4161. doi:10.7150/jca.21561. Available from http://www.jcancer.org/v08p4155.htm