J Cancer 2017; 8(17):3623-3630. doi:10.7150/jca.19438

Research Paper

High Intratumoral Expression of Tetranectin Associates with Poor Prognosis of Patients with Gastric Cancer after Gastrectomy

Hao Chen1*, Haojie Li1*, Junjie Zhao1*, Peike Peng2, 3, Miaomiao Shao2, 3, Hao Wu2, 3, Xuefei Wang1, Ling Chen1, Qi Zhang1, Yuanyuan Ruan2, 3✉, Fenglin Liu1✉, Yihong Sun1✉

1. Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China;
2. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, P.R. China;
3. Key Laboratory of Glycoconjugate Research Ministry of Public Health, School of Basic Medical Sciences, Fudan University, Shanghai 200032, P.R. China.
* These authors contributed equally to this work.

Abstract

Tetranectin, encoded by the clec3b gene, is a plasminogen kringle-4 binding protein that can be detected in the plasma and the extracellular matrix. In malignancies, tetranectin is thought to enhance proteolytic processes enabling tumor cells to invade and metastasize. Nevertheless, the prognostic value of tetranectin in gastric cancer remains elusive. In this study, we found the expression of tetranectin was decreased in gastric cancer. High intratumoral tetranectin level was positively associated with tumor invasion (P = 0.013), lymph node metastasis (P = 0.005), advanced TNM stage (P = 0.003) and shorter overall survival (OS) (P < 0.001) for patients with gastric cancer. Tetranectin expression was identified as an independent prognostic factor for poor OS, and combining tetranectin expression with other independent prognostic factors generated a predictive nomogram, which showed better prognostic efficiency for OS in patients with gastric cancer. In summary, our study suggests that intratumoral tetranectin is a potential independent unfavorable prognostic biomarker for OS of patients with gastric cancer after gastrectomy.

Keywords: Gastric cancer, Tetranectin, Prognosis, Nomogram.

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How to cite this article:
Chen H, Li H, Zhao J, Peng P, Shao M, Wu H, Wang X, Chen L, Zhang Q, Ruan Y, Liu F, Sun Y. High Intratumoral Expression of Tetranectin Associates with Poor Prognosis of Patients with Gastric Cancer after Gastrectomy. J Cancer 2017; 8(17):3623-3630. doi:10.7150/jca.19438. Available from http://www.jcancer.org/v08p3623.htm