J Cancer 2017; 8(15):3099-3104. doi:10.7150/jca.18032

Research Paper

Systematic Correlation Analyses of Circulating Tumor Cells with Clinical Variables and Tumor Markers in Lung Cancer Patients

Xu Wang1*, Kewei Ma1*, Zhiguang Yang3, Jiuwei Cui1, Hua He1, Andrew R. Hoffman2, Ji-Fan Hu1, 2✉, Wei Li1✉

1. Cancer and Stem Cell Center, First Affiliated Hospital, Jilin University, Changchun, Jilin 130061, P.R. China;
2. Stanford University Medical School, Palo Alto Veterans Institute for Research, Palo Alto, CA94304, USA;
3. Division of Thoracic Surgery, First Affiliated Hospital, Jilin University, Changchun, Jilin 130061, P.R. China.
* These are co-first authors.

Abstract

Measurement of circulating tumor cells (CTC) offers promise as a clinical biomarker to monitor disease status, therapeutic response, and progression in cancer patients. However, its clinical value in lung cancer patients has not been fully explored. We systematically evaluate the association of CTCs with clinical variables and tumor markers in a cohort of lung cancer patients. Using the CELLSEARCH System, CTCs were detected in both small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) patients prior to therapy. Univariate analysis revealed that detection of CTC was related to histology, stage, tumor size, invasiveness, and lymphatic metastasis. CTCs were associated with distant metastases in NSCLC, but not in SCLC. Using multivariate analysis, we found that CTCs were independently correlated with disease stage, SCLC, and elevated serum neuron-specific enolase (NSE). These data suggest that CTCs are more likely to be detected in patients with stage IV disease and with SCLC, and that elevated serum NSE predicts the presence of CTCs.

Keywords: Lung cancer, circulating tumor cells, serum neuron-specific enolase, epidemiologic factors, metastasis.

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How to cite this article:
Wang X, Ma K, Yang Z, Cui J, He H, Hoffman AR, Hu JF, Li W. Systematic Correlation Analyses of Circulating Tumor Cells with Clinical Variables and Tumor Markers in Lung Cancer Patients. J Cancer 2017; 8(15):3099-3104. doi:10.7150/jca.18032. Available from http://www.jcancer.org/v08p3099.htm